Matches in SemOpenAlex for { <https://semopenalex.org/work/W2141941738> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2141941738 endingPage "ep60" @default.
- W2141941738 startingPage "ep58" @default.
- W2141941738 abstract "We studied the influence of protein, pH and species on phencyclidine (PCP) protein binding. PCP binding to dog serum was unaffected by high concentrations of PCP and metabolites. The percentage of unbound PCP in pooled human serum and plasma specimens and pooled dog serum specimens was (mean +/- S.D.): 48.3 +/- 2.5; 42.5 +/- 1.8; and 43.3 +/- 1.9%, respectively. The percentage of unbound PCP in human serum albumin (HSA), 81.2 +/- 2.0%, was constant over the physiological HSA concentration range (3.5-5.5 g/dl). The binding of PCP to alpha 1-acid glycoprotein (alpha 1-AGP) increased with increasing alpha 1-AGP concentration (50-200 mg/dl). The binding to HSA or alpha 1-AGP separately did not account for the binding found in whole serum or plasma specimens. However, when a constant concentration of HSA (4.5 g/dl) was added to varying concentrations of alpha 1-AGP, the PCP binding increased dramatically and was similar to the binding found in human serum specimens. The association constant in the presence of both proteins (7.72 X 10(4) M-1) was 4.4 times greater than the association constant for alpha 1-AGP alone (1.74 X 10(4) M-1). This suggested an interaction between the proteins which resulted in enhanced PCP binding. The percentage of unbound PCP increased with decreasing pH in both dog serum and human serum specimens. This change could have possible effects on PCP distribution and elimination. The PCP blood to plasma ratio was 0.94 in pooled human heparinized blood and 1.25 in pooled dog heparinized blood. Neither species showed PCP concentration-dependent partitioning." @default.
- W2141941738 created "2016-06-24" @default.
- W2141941738 creator A5082633643 @default.
- W2141941738 date "2006-08-01" @default.
- W2141941738 modified "2023-10-16" @default.
- W2141941738 title "GLUCOCORTICOID TREATMENT IN CROUP" @default.
- W2141941738 cites W1556694909 @default.
- W2141941738 cites W1949163494 @default.
- W2141941738 cites W1991886128 @default.
- W2141941738 cites W2106942743 @default.
- W2141941738 cites W2136829447 @default.
- W2141941738 cites W2601271328 @default.
- W2141941738 cites W3135185800 @default.
- W2141941738 doi "https://doi.org/10.1136/adc.2006.094854" @default.
- W2141941738 hasPublicationYear "2006" @default.
- W2141941738 type Work @default.
- W2141941738 sameAs 2141941738 @default.
- W2141941738 citedByCount "3" @default.
- W2141941738 crossrefType "journal-article" @default.
- W2141941738 hasAuthorship W2141941738A5082633643 @default.
- W2141941738 hasConcept C108625454 @default.
- W2141941738 hasConcept C126322002 @default.
- W2141941738 hasConcept C134018914 @default.
- W2141941738 hasConcept C146543888 @default.
- W2141941738 hasConcept C165616093 @default.
- W2141941738 hasConcept C170493617 @default.
- W2141941738 hasConcept C185592680 @default.
- W2141941738 hasConcept C2776125364 @default.
- W2141941738 hasConcept C2778597219 @default.
- W2141941738 hasConcept C2778851735 @default.
- W2141941738 hasConcept C2780841215 @default.
- W2141941738 hasConcept C30787643 @default.
- W2141941738 hasConcept C43617362 @default.
- W2141941738 hasConcept C51639874 @default.
- W2141941738 hasConcept C55493867 @default.
- W2141941738 hasConcept C67018056 @default.
- W2141941738 hasConcept C71924100 @default.
- W2141941738 hasConcept C86803240 @default.
- W2141941738 hasConceptScore W2141941738C108625454 @default.
- W2141941738 hasConceptScore W2141941738C126322002 @default.
- W2141941738 hasConceptScore W2141941738C134018914 @default.
- W2141941738 hasConceptScore W2141941738C146543888 @default.
- W2141941738 hasConceptScore W2141941738C165616093 @default.
- W2141941738 hasConceptScore W2141941738C170493617 @default.
- W2141941738 hasConceptScore W2141941738C185592680 @default.
- W2141941738 hasConceptScore W2141941738C2776125364 @default.
- W2141941738 hasConceptScore W2141941738C2778597219 @default.
- W2141941738 hasConceptScore W2141941738C2778851735 @default.
- W2141941738 hasConceptScore W2141941738C2780841215 @default.
- W2141941738 hasConceptScore W2141941738C30787643 @default.
- W2141941738 hasConceptScore W2141941738C43617362 @default.
- W2141941738 hasConceptScore W2141941738C51639874 @default.
- W2141941738 hasConceptScore W2141941738C55493867 @default.
- W2141941738 hasConceptScore W2141941738C67018056 @default.
- W2141941738 hasConceptScore W2141941738C71924100 @default.
- W2141941738 hasConceptScore W2141941738C86803240 @default.
- W2141941738 hasIssue "2" @default.
- W2141941738 hasLocation W21419417381 @default.
- W2141941738 hasOpenAccess W2141941738 @default.
- W2141941738 hasPrimaryLocation W21419417381 @default.
- W2141941738 hasRelatedWork W120024146 @default.
- W2141941738 hasRelatedWork W2013886887 @default.
- W2141941738 hasRelatedWork W2018385296 @default.
- W2141941738 hasRelatedWork W2051645596 @default.
- W2141941738 hasRelatedWork W2067514158 @default.
- W2141941738 hasRelatedWork W2073638061 @default.
- W2141941738 hasRelatedWork W2127867331 @default.
- W2141941738 hasRelatedWork W2141941738 @default.
- W2141941738 hasRelatedWork W2162632962 @default.
- W2141941738 hasRelatedWork W2332054480 @default.
- W2141941738 hasVolume "91" @default.
- W2141941738 isParatext "false" @default.
- W2141941738 isRetracted "false" @default.
- W2141941738 magId "2141941738" @default.
- W2141941738 workType "article" @default.