FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2141962812> ?p ?o ?g. }

• W2141962812 abstract "Alzheimer’s disease (AD) is characterized by the deposition of amyloid-β (Aβ), which is associated with a neuroinflammatory response involving microglia and astrocytes. This neuroinflammatory response has detrimental effects on disease progression but also has a beneficial function on removal of excess Aβ. Microglia and astrocytes are involved in the clearance of Aβ from the brain, but neuroinflammation also promotes neurodegeneration. In order to identify signal transduction pathways critically involved in AD we analysed human brain tissue using protein kinase activity profiling. We identified increased activity of the Interleukin 1 Receptor Associated Kinase 4 (IRAK-4) in AD compared to control brain tissue. IRAK-4 is a component of the signal transduction pathway that functions downstream of the Toll-like receptors and the interleukin-1 receptor. Immunohistochemical analysis of human brain tissue revealed the presence of IRAK-4 in astrocytes and microglia. Quantification of IRAK-4 and the phosphorylated form of IRAK-1, a specific substrate for IRAK-4, revealed increased expression and activity of IRAK-4 in AD. Interestingly, IRAK-1/4 inhibitor I reduces the lipopolysaccharide-induced secretion of monocyte chemotactic protein-1 (MCP-1) by primary human microglia and the interleukin-1β-induced secretion of MCP-1 and interleukin 6 by primary human astrocytes. In contrast, the uptake of Aβ by astrocytes and microglia is not affected by IRAK-1/4 inhibition. Our data show that IRAK-4 protein kinase activity is increased in AD and selective inhibition of IRAK-1/4 inhibits a pro-inflammatory response without affecting the uptake of Aβ by glial cells, indicating that the IRAK signalling pathway is a potential target for modulating neuroinflammation in AD." @default.
• W2141962812 created "2016-06-24" @default.
• W2141962812 creator A5014287588 @default.
• W2141962812 creator A5027733537 @default.
• W2141962812 creator A5027844480 @default.
• W2141962812 creator A5038766554 @default.
• W2141962812 creator A5053882105 @default.
• W2141962812 creator A5060681084 @default.
• W2141962812 creator A5079118533 @default.
• W2141962812 creator A5088817453 @default.
• W2141962812 creator A5091877683 @default.
• W2141962812 date "2014-01-01" @default.
• W2141962812 modified "2023-09-24" @default.
• W2141962812 title "Increased IRAK-4 Kinase Activity in Alzheimer’s Disease; IRAK-1/4 Inhibitor I Prevents Pro-inflammatory Cytokine Secretion but not the Uptake of Amyloid Beta by Primary Human Glia" @default.
• W2141962812 cites W1893620705 @default.
• W2141962812 cites W1969054252 @default.
• W2141962812 cites W1969501356 @default.
• W2141962812 cites W1969994474 @default.
• W2141962812 cites W1972891705 @default.
• W2141962812 cites W1977585036 @default.
• W2141962812 cites W1982464478 @default.
• W2141962812 cites W1983430176 @default.
• W2141962812 cites W1998585620 @default.
• W2141962812 cites W2015186493 @default.
• W2141962812 cites W2024644969 @default.
• W2141962812 cites W2030914021 @default.
• W2141962812 cites W2039797184 @default.
• W2141962812 cites W2053953952 @default.
• W2141962812 cites W2067121616 @default.
• W2141962812 cites W2068477037 @default.
• W2141962812 cites W2069214614 @default.
• W2141962812 cites W2076260194 @default.
• W2141962812 cites W2077332810 @default.
• W2141962812 cites W2079863749 @default.
• W2141962812 cites W2083556882 @default.
• W2141962812 cites W2091102323 @default.
• W2141962812 cites W2093025761 @default.
• W2141962812 cites W2095017048 @default.
• W2141962812 cites W2111015407 @default.
• W2141962812 cites W2113075523 @default.
• W2141962812 cites W2116784956 @default.
• W2141962812 cites W2120064876 @default.
• W2141962812 cites W2123288685 @default.
• W2141962812 cites W2135955660 @default.
• W2141962812 cites W2149399096 @default.
• W2141962812 cites W2154346600 @default.
• W2141962812 cites W2155965284 @default.
• W2141962812 cites W2158043506 @default.
• W2141962812 cites W2171403795 @default.
• W2141962812 cites W32083764 @default.
• W2141962812 doi "https://doi.org/10.4172/2155-9899.1000243" @default.
• W2141962812 hasPublicationYear "2014" @default.
• W2141962812 type Work @default.
• W2141962812 sameAs 2141962812 @default.
• W2141962812 citedByCount "4" @default.
• W2141962812 countsByYear W21419628122015 @default.
• W2141962812 countsByYear W21419628122023 @default.
• W2141962812 crossrefType "journal-article" @default.
• W2141962812 hasAuthorship W2141962812A5014287588 @default.
• W2141962812 hasAuthorship W2141962812A5027733537 @default.
• W2141962812 hasAuthorship W2141962812A5027844480 @default.
• W2141962812 hasAuthorship W2141962812A5038766554 @default.
• W2141962812 hasAuthorship W2141962812A5053882105 @default.
• W2141962812 hasAuthorship W2141962812A5060681084 @default.
• W2141962812 hasAuthorship W2141962812A5079118533 @default.
• W2141962812 hasAuthorship W2141962812A5088817453 @default.
• W2141962812 hasAuthorship W2141962812A5091877683 @default.
• W2141962812 hasConcept C126322002 @default.
• W2141962812 hasConcept C142724271 @default.
• W2141962812 hasConcept C184235292 @default.
• W2141962812 hasConcept C199360897 @default.
• W2141962812 hasConcept C203014093 @default.
• W2141962812 hasConcept C2776156579 @default.
• W2141962812 hasConcept C2776174256 @default.
• W2141962812 hasConcept C2776914184 @default.
• W2141962812 hasConcept C2777633098 @default.
• W2141962812 hasConcept C2778690821 @default.
• W2141962812 hasConcept C2779134260 @default.
• W2141962812 hasConcept C2779830541 @default.
• W2141962812 hasConcept C41008148 @default.
• W2141962812 hasConcept C49039625 @default.
• W2141962812 hasConcept C502032728 @default.
• W2141962812 hasConcept C71924100 @default.
• W2141962812 hasConcept C86803240 @default.
• W2141962812 hasConcept C95444343 @default.
• W2141962812 hasConcept C98274493 @default.
• W2141962812 hasConceptScore W2141962812C126322002 @default.
• W2141962812 hasConceptScore W2141962812C142724271 @default.
• W2141962812 hasConceptScore W2141962812C184235292 @default.
• W2141962812 hasConceptScore W2141962812C199360897 @default.
• W2141962812 hasConceptScore W2141962812C203014093 @default.
• W2141962812 hasConceptScore W2141962812C2776156579 @default.
• W2141962812 hasConceptScore W2141962812C2776174256 @default.
• W2141962812 hasConceptScore W2141962812C2776914184 @default.
• W2141962812 hasConceptScore W2141962812C2777633098 @default.
• W2141962812 hasConceptScore W2141962812C2778690821 @default.
• W2141962812 hasConceptScore W2141962812C2779134260 @default.
• W2141962812 hasConceptScore W2141962812C2779830541 @default.
• W2141962812 hasConceptScore W2141962812C41008148 @default.
• W2141962812 hasConceptScore W2141962812C49039625 @default.

• next