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• W2141975829 startingPage "12186" @default.
• W2141975829 abstract "The structural maintenance of neural circuits is critical for higher brain functions in adulthood. Although several molecules have been identified as regulators for spine maintenance in hippocampal and cortical neurons, it is poorly understood how Purkinje cell (PC) spines are maintained in the mature cerebellum. Here we show that the calcium channel type 1 inositol trisphosphate receptor (IP₃R1) in PCs plays a crucial role in controlling the maintenance of parallel fiber (PF)–PC synaptic circuits in the mature cerebellum <i>in vivo</i>. Significantly, adult mice lacking IP₃R1 specifically in PCs (<i>L7-Cre;Itpr1^flox/flox</i>) showed dramatic increase in spine density and spine length of PCs, despite having normal spines during development. In addition, the abnormally rearranged PF–PC synaptic circuits in mature cerebellum caused unexpectedly severe ataxia in adult <i>L7-Cre;Itpr1^flox/flox</i> mice. Our findings reveal a specific role for IP₃R1 in PCs not only as an intracellular mediator of cerebellar synaptic plasticity induction, but also as a critical regulator of PF–PC synaptic circuit maintenance in the mature cerebellum <i>in vivo</i>; this mechanism may underlie motor coordination and learning in adults." @default.
• W2141975829 created "2016-06-24" @default.
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• W2141975829 date "2013-07-24" @default.
• W2141975829 modified "2023-10-15" @default.
• W2141975829 title "Type 1 Inositol Trisphosphate Receptor Regulates Cerebellar Circuits by Maintaining the Spine Morphology of Purkinje Cells in Adult Mice" @default.
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• W2141975829 doi "https://doi.org/10.1523/jneurosci.0545-13.2013" @default.
• W2141975829 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6618669" @default.
• W2141975829 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23884927" @default.
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