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- W2141979722 abstract "Lanthanide-doped upconversion nanoparticles (UCNPs) have shown great promise in versatile bioapplications. For the first time, organosilica-shelled β-NaLuF4:Gd/Yb/Er nanoprobes with a rattle structure have been designed for dual-modal imaging and photodynamic therapy (PDT). Benefiting from the unique rattle structure and aromatic framework, these nanoprobes are endowed with a high loading capacity and the disaggregation effect of photosensitizers. After loading of β-carboxyphthalocyanine zinc or rose Bengal into the nanoprobes, we achieved higher energy transfer efficiency from UCNPs to photosensitizers as compared to those with conventional core-shell structure or with pure-silica shell, which facilitates a large production of singlet oxygen and thus an enhanced PDT efficacy. We demonstrated the use of these nanoprobes in proof-of-concept X-ray computed tomography (CT) and UC imaging, thus revealing the great potential of this multifunctional material as an excellent nanoplatform for cancer theranostics." @default.
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- W2141979722 date "2015-05-26" @default.
- W2141979722 modified "2023-10-18" @default.
- W2141979722 title "Multifunctional Nano-Bioprobes Based on Rattle-Structured Upconverting Luminescent Nanoparticles" @default.
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- W2141979722 doi "https://doi.org/10.1002/anie.201501468" @default.
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