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• W2142014345 abstract "Virus-specific CD8+ T cells play an important role in controlling viral infections including human immunodeficiency virus (HIV) infection. However, during chronic HIV infection, virus-specific CD8+ T cells undergo functional exhaustion, lose effector functions and fail to control viral infection. HIV-specific CD8 T cells expressing high levels of co-inhibitory molecule programmed death-1 (PD-1) during the chronic infection and are characterized by lower proliferation, cytokine production, and cytotoxic abilities. Although, antiretroviral therapy has resulted in dramatic decline in HIV replication, there is no effective treatment currently available to eradicate viral reservoirs or restore virus-specific T or B-cell functions that may complement ART in order to eliminate the virus. In recent years, studies in mice and non-human primate models of HIV infection demonstrated the functional exhaustion of virus-specific T and B cells could be reversed by blockade of interaction between PD-1 and its cognate ligands (PD-L1 and PD-L2). In this review, we discuss recent advances in our understanding of PD-1 pathway in HIV/SIV infection and discuss the beneficial effects of PD-1 blockade during chronic HIV/SIV infection and its potential role as immunotherapy for HIV/AIDS." @default.
• W2142014345 created "2016-06-24" @default.
• W2142014345 creator A5034939111 @default.
• W2142014345 creator A5042801011 @default.
• W2142014345 creator A5067039452 @default.
• W2142014345 creator A5069264423 @default.
• W2142014345 date "2015-02-08" @default.
• W2142014345 modified "2023-09-23" @default.
• W2142014345 title "Role of PD-1 co-inhibitory pathway in HIV infection and potential therapeutic options" @default.
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