FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142021867> ?p ?o ?g. }

• W2142021867 abstract "Introduction: Neoadjuvant chemotherapy is the standard treatment modality in locally advanced breast cancer, and accepted as an alternate modality in operable breast cancer. Pathological Complete Response (pCR) is a surrogate for better outcome. The identification of the most sensitive clinical and radiological method to pCR will be helpful in patient’s management.Patients and methods: Multicenterprospective study assessed the correlation between (pCR) and radiological Complete Response (rCR) using different radiological modalities. 125 female with primary measurable stage II or III non inflammatory breast cancer, were enrolled in the study after pathological confirmation using image guided core biopsy. Pathological assessment was done. All eligible cases received neoadjuvant chemotherapy (FEC) IV every 3 weeks for three cycles followed by Docetaxel IV every 3 weeks for three cycles. Trastuzumab was added in Her2neu positive patients concomitantly with docetaxel. Radiological evaluation was done before chemotherapy and prior to definitive surgery. pCR was defined as complete disappearance of invasive tumor cells in both breast surgical specimen and lymph nodes. Patients who achieved pCR were correlated with truly positive rCR by different modalities. The results were statistically analyzed using the Kappa method for agreement.Results: 20% of the patients achieved pCR 25/125. All these patients received 6 cycles of chemotherapy, only 4 patients received Trastuzumab. Conservative surgery was performed in 80% of cases and MRM in 5/25 of them. True radiological Complete Response (rCR) was achieved in 56% of patients by mammography, 17/25 (68%) of patients by ultrasonography who showed complete disappearance of the mass. 23/25 (92%) achieved rCR morphologically by Dynamic MR-Mammography and in 24/25 (96%) of cases using the kinetic data. MR Spectroscopy showed rCR in (92%) cases. In our study, predictions made on the basis of MRI showed a better correlation with the pathological response after neoadjuvant chemotherapy than did estimations made on the basis of mammography or sonography. The sensitivity, specificity, PPV and NPV for Dynamic MRI in predicting complete pathological response were 96%, 94%, 89% and 99% respectively. The sensitivity, specificity, PPV and NPV for MRS were 92%, 92%, 85% and 97% respectively while the sensitivity, specificity, PPV and NPV for Mammography were 44%, 87%, 61% and 87% respectively and the sensitivity, specificity, PPV and NPV for ultrasonography were 68%, 90%, 77% and 92% respectively.Conclusion: The most sensitive radiological methods correlated with pCR were dynamic MR mammography and MR Spectroscopy, further studies using new modalities and larger number of patients is required to confirm our results." @default.
• W2142021867 created "2016-06-24" @default.
• W2142021867 creator A5059447763 @default.
• W2142021867 date "2013-01-01" @default.
• W2142021867 modified "2023-09-25" @default.
• W2142021867 title "Correlation of Pathological Complete Response with Radiological Evaluation after Neoadjuvant Chemotherapy of Breast Carcinoma" @default.
• W2142021867 cites W1777215171 @default.
• W2142021867 cites W1968822078 @default.
• W2142021867 cites W1974604792 @default.
• W2142021867 cites W1985516002 @default.
• W2142021867 cites W2017098623 @default.
• W2142021867 cites W2023139686 @default.
• W2142021867 cites W2023944710 @default.
• W2142021867 cites W2026686462 @default.
• W2142021867 cites W2026981776 @default.
• W2142021867 cites W2058085109 @default.
• W2142021867 cites W2060085341 @default.
• W2142021867 cites W2087562335 @default.
• W2142021867 cites W2096145980 @default.
• W2142021867 cites W2096620495 @default.
• W2142021867 cites W2127650183 @default.
• W2142021867 doi "https://doi.org/10.4172/2157-7013.1000149" @default.
• W2142021867 hasPublicationYear "2013" @default.
• W2142021867 type Work @default.
• W2142021867 sameAs 2142021867 @default.
• W2142021867 citedByCount "1" @default.
• W2142021867 countsByYear W21420218672021 @default.
• W2142021867 crossrefType "journal-article" @default.
• W2142021867 hasAuthorship W2142021867A5059447763 @default.
• W2142021867 hasBestOaLocation W21420218671 @default.
• W2142021867 hasConcept C117220453 @default.
• W2142021867 hasConcept C121608353 @default.
• W2142021867 hasConcept C126322002 @default.
• W2142021867 hasConcept C126838900 @default.
• W2142021867 hasConcept C143998085 @default.
• W2142021867 hasConcept C190892606 @default.
• W2142021867 hasConcept C207886595 @default.
• W2142021867 hasConcept C2524010 @default.
• W2142021867 hasConcept C2776694085 @default.
• W2142021867 hasConcept C2778292576 @default.
• W2142021867 hasConcept C3018521938 @default.
• W2142021867 hasConcept C3019096185 @default.
• W2142021867 hasConcept C33923547 @default.
• W2142021867 hasConcept C530470458 @default.
• W2142021867 hasConcept C71924100 @default.
• W2142021867 hasConceptScore W2142021867C117220453 @default.
• W2142021867 hasConceptScore W2142021867C121608353 @default.
• W2142021867 hasConceptScore W2142021867C126322002 @default.
• W2142021867 hasConceptScore W2142021867C126838900 @default.
• W2142021867 hasConceptScore W2142021867C143998085 @default.
• W2142021867 hasConceptScore W2142021867C190892606 @default.
• W2142021867 hasConceptScore W2142021867C207886595 @default.
• W2142021867 hasConceptScore W2142021867C2524010 @default.
• W2142021867 hasConceptScore W2142021867C2776694085 @default.
• W2142021867 hasConceptScore W2142021867C2778292576 @default.
• W2142021867 hasConceptScore W2142021867C3018521938 @default.
• W2142021867 hasConceptScore W2142021867C3019096185 @default.
• W2142021867 hasConceptScore W2142021867C33923547 @default.
• W2142021867 hasConceptScore W2142021867C530470458 @default.
• W2142021867 hasConceptScore W2142021867C71924100 @default.
• W2142021867 hasIssue "03" @default.
• W2142021867 hasLocation W21420218671 @default.
• W2142021867 hasOpenAccess W2142021867 @default.
• W2142021867 hasPrimaryLocation W21420218671 @default.
• W2142021867 hasRelatedWork W1970677298 @default.
• W2142021867 hasRelatedWork W2133675782 @default.
• W2142021867 hasRelatedWork W2161568138 @default.
• W2142021867 hasRelatedWork W2365134123 @default.
• W2142021867 hasRelatedWork W2367335376 @default.
• W2142021867 hasRelatedWork W2588049562 @default.
• W2142021867 hasRelatedWork W2932823665 @default.
• W2142021867 hasRelatedWork W3030823012 @default.
• W2142021867 hasRelatedWork W4206561586 @default.
• W2142021867 hasRelatedWork W3128871921 @default.
• W2142021867 hasVolume "04" @default.
• W2142021867 isParatext "false" @default.
• W2142021867 isRetracted "false" @default.
• W2142021867 magId "2142021867" @default.
• W2142021867 workType "article" @default.