Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142068049> ?p ?o ?g. }
- W2142068049 endingPage "207" @default.
- W2142068049 startingPage "198" @default.
- W2142068049 abstract "Genetic analysis in Arabidopsis has led to the identification of several genes that are required for auxin response. One of these genes, AXR1, encodes a protein related to yeast Aos1p, a protein that functions to activate the ubiquitin-related protein Smt3p. Here we report the identification of a new gene called TRANSPORT INHIBITOR RESPONSE 1 (TIR1). The tir1 mutants are deficient in a variety of auxin-regulated growth processes including hypocotyl elongation and lateral root formation. These results indicate that TIR1 is also required for normal response to auxin. Further, mutations in TIR1 display a synergistic interaction with mutations in AXR1, suggesting that the two genes function in overlapping pathways. The TIR1 protein contains a series of leucine-rich repeats and a recently identified motif called an F box. Sequence comparisons indicate that TIR1 is related to the yeast protein Grr1p and the human protein SKP2. Because Grr1p and other F-box proteins have been implicated in ubiquitin-mediated processes, we speculate that auxin response depends on the modification of a key regulatory protein(s) by ubiquitin or a ubiquitin-related protein." @default.
- W2142068049 created "2016-06-24" @default.
- W2142068049 creator A5001257345 @default.
- W2142068049 creator A5021845817 @default.
- W2142068049 creator A5043774560 @default.
- W2142068049 creator A5064356638 @default.
- W2142068049 creator A5084551242 @default.
- W2142068049 creator A5087336699 @default.
- W2142068049 date "1998-01-15" @default.
- W2142068049 modified "2023-10-17" @default.
- W2142068049 title "The TIR1 protein of <i>Arabidopsis</i> functions in auxin response and is related to human SKP2 and yeast Grr1p" @default.
- W2142068049 cites W158828584 @default.
- W2142068049 cites W1963701865 @default.
- W2142068049 cites W1966034049 @default.
- W2142068049 cites W1970061483 @default.
- W2142068049 cites W1970763447 @default.
- W2142068049 cites W1979517563 @default.
- W2142068049 cites W1980693532 @default.
- W2142068049 cites W1980900314 @default.
- W2142068049 cites W1981243923 @default.
- W2142068049 cites W1984242659 @default.
- W2142068049 cites W1990376824 @default.
- W2142068049 cites W2005975510 @default.
- W2142068049 cites W2015997780 @default.
- W2142068049 cites W2024683589 @default.
- W2142068049 cites W2028638629 @default.
- W2142068049 cites W2033228162 @default.
- W2142068049 cites W2045301408 @default.
- W2142068049 cites W2051882412 @default.
- W2142068049 cites W2060385362 @default.
- W2142068049 cites W2065624112 @default.
- W2142068049 cites W2075124527 @default.
- W2142068049 cites W2077245868 @default.
- W2142068049 cites W2080273350 @default.
- W2142068049 cites W2080713788 @default.
- W2142068049 cites W2081110616 @default.
- W2142068049 cites W2089601621 @default.
- W2142068049 cites W2095327781 @default.
- W2142068049 cites W2103023733 @default.
- W2142068049 cites W2105382611 @default.
- W2142068049 cites W2109800411 @default.
- W2142068049 cites W2129280965 @default.
- W2142068049 cites W2132387250 @default.
- W2142068049 cites W2132491389 @default.
- W2142068049 cites W2135659255 @default.
- W2142068049 cites W2140138777 @default.
- W2142068049 cites W2146526817 @default.
- W2142068049 cites W2158366682 @default.
- W2142068049 cites W2159427781 @default.
- W2142068049 cites W2180394745 @default.
- W2142068049 cites W2182474766 @default.
- W2142068049 cites W2614129033 @default.
- W2142068049 cites W4246570214 @default.
- W2142068049 doi "https://doi.org/10.1101/gad.12.2.198" @default.
- W2142068049 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/316440" @default.
- W2142068049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9436980" @default.
- W2142068049 hasPublicationYear "1998" @default.
- W2142068049 type Work @default.
- W2142068049 sameAs 2142068049 @default.
- W2142068049 citedByCount "624" @default.
- W2142068049 countsByYear W21420680492012 @default.
- W2142068049 countsByYear W21420680492013 @default.
- W2142068049 countsByYear W21420680492014 @default.
- W2142068049 countsByYear W21420680492015 @default.
- W2142068049 countsByYear W21420680492016 @default.
- W2142068049 countsByYear W21420680492017 @default.
- W2142068049 countsByYear W21420680492018 @default.
- W2142068049 countsByYear W21420680492019 @default.
- W2142068049 countsByYear W21420680492020 @default.
- W2142068049 countsByYear W21420680492021 @default.
- W2142068049 countsByYear W21420680492022 @default.
- W2142068049 countsByYear W21420680492023 @default.
- W2142068049 crossrefType "journal-article" @default.
- W2142068049 hasAuthorship W2142068049A5001257345 @default.
- W2142068049 hasAuthorship W2142068049A5021845817 @default.
- W2142068049 hasAuthorship W2142068049A5043774560 @default.
- W2142068049 hasAuthorship W2142068049A5064356638 @default.
- W2142068049 hasAuthorship W2142068049A5084551242 @default.
- W2142068049 hasAuthorship W2142068049A5087336699 @default.
- W2142068049 hasBestOaLocation W21420680491 @default.
- W2142068049 hasConcept C104317684 @default.
- W2142068049 hasConcept C131312102 @default.
- W2142068049 hasConcept C134459356 @default.
- W2142068049 hasConcept C140248907 @default.
- W2142068049 hasConcept C143065580 @default.
- W2142068049 hasConcept C167625842 @default.
- W2142068049 hasConcept C174851938 @default.
- W2142068049 hasConcept C180196505 @default.
- W2142068049 hasConcept C207230331 @default.
- W2142068049 hasConcept C207778908 @default.
- W2142068049 hasConcept C25602115 @default.
- W2142068049 hasConcept C2779222958 @default.
- W2142068049 hasConcept C2779491563 @default.
- W2142068049 hasConcept C2908868211 @default.
- W2142068049 hasConcept C55493867 @default.
- W2142068049 hasConcept C83713313 @default.
- W2142068049 hasConcept C86803240 @default.
- W2142068049 hasConcept C95444343 @default.