FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142114138> ?p ?o ?g. }

• W2142114138 endingPage "1491" @default.
• W2142114138 startingPage "1485" @default.
• W2142114138 abstract "To evaluate the safety and pharmacology of the intraperitoneal (IP) administration of the antineoplastic agent taxol.Twenty-five pretreated patients who were entered onto a phase I clinical trial; 24 had advanced ovarian cancer. Patients were treated with taxol administered IP in 2 L of normal saline every 3 to 4 weeks. The starting dose was 25 mg/m2. There were no intrapatient dose escalations.The dose-limiting toxicity was the development of severe abdominal pain at taxol doses more than 175 mg/m2. Moderate leukopenia (WBC count less than 2,000/mm3) was observed at IP doses of greater than or equal to 175 mg/m2. The exposure of the peritoneal cavity (peak levels and area under the time-versus-concentration curve [AUC]) to taxol after IP delivery exceeded that of the plasma by approximately 1,000-fold. However, concentrations of the agent previously shown to produce cytotoxicity in experimental systems were demonstrated in the systemic compartment after regional delivery, which was considered important. Significant concentrations of taxol persisted within the peritoneal cavity for more than 24 to 48 hours after a single IP installation. Several antitumor responses, which included control of platinum-refractory ascites, were documented.Taxol can be delivered by the IP route with both an acceptable toxicity profile and a major pharmacokinetic advantage for cavity exposure." @default.
• W2142114138 created "2016-06-24" @default.
• W2142114138 creator A5011905014 @default.
• W2142114138 creator A5012218355 @default.
• W2142114138 creator A5012517342 @default.
• W2142114138 creator A5017271527 @default.
• W2142114138 creator A5046038187 @default.
• W2142114138 creator A5067983681 @default.
• W2142114138 creator A5068790150 @default.
• W2142114138 creator A5070270740 @default.
• W2142114138 creator A5084928787 @default.
• W2142114138 creator A5086908552 @default.
• W2142114138 date "1992-09-01" @default.
• W2142114138 modified "2023-10-16" @default.
• W2142114138 title "Phase I trial of intraperitoneal taxol: a Gynecoloic Oncology Group study." @default.
• W2142114138 cites W1779739875 @default.
• W2142114138 cites W1878603103 @default.
• W2142114138 cites W1935541780 @default.
• W2142114138 cites W1981534406 @default.
• W2142114138 cites W1987624243 @default.
• W2142114138 cites W2015174062 @default.
• W2142114138 cites W2081406767 @default.
• W2142114138 cites W2132574756 @default.
• W2142114138 cites W2143202928 @default.
• W2142114138 cites W2401691189 @default.
• W2142114138 cites W2409767001 @default.
• W2142114138 doi "https://doi.org/10.1200/jco.1992.10.9.1485" @default.
• W2142114138 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1355523" @default.
• W2142114138 hasPublicationYear "1992" @default.
• W2142114138 type Work @default.
• W2142114138 sameAs 2142114138 @default.
• W2142114138 citedByCount "272" @default.
• W2142114138 countsByYear W21421141382012 @default.
• W2142114138 countsByYear W21421141382013 @default.
• W2142114138 countsByYear W21421141382014 @default.
• W2142114138 countsByYear W21421141382015 @default.
• W2142114138 countsByYear W21421141382016 @default.
• W2142114138 countsByYear W21421141382017 @default.
• W2142114138 countsByYear W21421141382018 @default.
• W2142114138 countsByYear W21421141382019 @default.
• W2142114138 countsByYear W21421141382020 @default.
• W2142114138 countsByYear W21421141382021 @default.
• W2142114138 countsByYear W21421141382022 @default.
• W2142114138 countsByYear W21421141382023 @default.
• W2142114138 crossrefType "journal-article" @default.
• W2142114138 hasAuthorship W2142114138A5011905014 @default.
• W2142114138 hasAuthorship W2142114138A5012218355 @default.
• W2142114138 hasAuthorship W2142114138A5012517342 @default.
• W2142114138 hasAuthorship W2142114138A5017271527 @default.
• W2142114138 hasAuthorship W2142114138A5046038187 @default.
• W2142114138 hasAuthorship W2142114138A5067983681 @default.
• W2142114138 hasAuthorship W2142114138A5068790150 @default.
• W2142114138 hasAuthorship W2142114138A5070270740 @default.
• W2142114138 hasAuthorship W2142114138A5084928787 @default.
• W2142114138 hasAuthorship W2142114138A5086908552 @default.
• W2142114138 hasConcept C112705442 @default.
• W2142114138 hasConcept C121332964 @default.
• W2142114138 hasConcept C121608353 @default.
• W2142114138 hasConcept C126322002 @default.
• W2142114138 hasConcept C141071460 @default.
• W2142114138 hasConcept C142424586 @default.
• W2142114138 hasConcept C2776694085 @default.
• W2142114138 hasConcept C2777288759 @default.
• W2142114138 hasConcept C2777397205 @default.
• W2142114138 hasConcept C2778536324 @default.
• W2142114138 hasConcept C2780427987 @default.
• W2142114138 hasConcept C2780496750 @default.
• W2142114138 hasConcept C2780873365 @default.
• W2142114138 hasConcept C29730261 @default.
• W2142114138 hasConcept C71924100 @default.
• W2142114138 hasConcept C87355193 @default.
• W2142114138 hasConcept C98274493 @default.
• W2142114138 hasConceptScore W2142114138C112705442 @default.
• W2142114138 hasConceptScore W2142114138C121332964 @default.
• W2142114138 hasConceptScore W2142114138C121608353 @default.
• W2142114138 hasConceptScore W2142114138C126322002 @default.
• W2142114138 hasConceptScore W2142114138C141071460 @default.
• W2142114138 hasConceptScore W2142114138C142424586 @default.
• W2142114138 hasConceptScore W2142114138C2776694085 @default.
• W2142114138 hasConceptScore W2142114138C2777288759 @default.
• W2142114138 hasConceptScore W2142114138C2777397205 @default.
• W2142114138 hasConceptScore W2142114138C2778536324 @default.
• W2142114138 hasConceptScore W2142114138C2780427987 @default.
• W2142114138 hasConceptScore W2142114138C2780496750 @default.
• W2142114138 hasConceptScore W2142114138C2780873365 @default.
• W2142114138 hasConceptScore W2142114138C29730261 @default.
• W2142114138 hasConceptScore W2142114138C71924100 @default.
• W2142114138 hasConceptScore W2142114138C87355193 @default.
• W2142114138 hasConceptScore W2142114138C98274493 @default.
• W2142114138 hasIssue "9" @default.
• W2142114138 hasLocation W21421141381 @default.
• W2142114138 hasLocation W21421141382 @default.
• W2142114138 hasOpenAccess W2142114138 @default.
• W2142114138 hasPrimaryLocation W21421141381 @default.
• W2142114138 hasRelatedWork W1994139814 @default.
• W2142114138 hasRelatedWork W2004325424 @default.
• W2142114138 hasRelatedWork W2051036097 @default.
• W2142114138 hasRelatedWork W2062650038 @default.

• next