FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142134221> ?p ?o ?g. }

• W2142134221 endingPage "730" @default.
• W2142134221 startingPage "721" @default.
• W2142134221 abstract "Abstract Ethanol toxicity and its effect on ethanol production by the recombinant ethanologenic Escherichia coli strain KO11 were investigated in batch and continuous fermentation. During batch growth, ethanol produced by KO11 reduced both the specific cell growth rate ( µ ) and the cell yield ( Y X/S ). The extent of inhibition increased with the production of both acetate and lactate. Subsequent accumulation of these metabolites and ethanol resulted in cessation of cell growth, redirection of metabolism to reduce ethanol production, and increased requirements for cell maintenance. These effects were found to depend on both the glycolytic flux and the flux from pyruvate to ethanol. Pyruvate decarboxylase (Pdc) and alcohol dehydrogenase (Adh) activities measured during the batch fermentation suggested that decreased ethanol production resulted from enzyme inhibition rather than down‐regulation of genes in the ethanol‐producing pathway. Ethanol was added in continuous fermentation to provide an ethanol concentration of either 17 or 27 g/L, triggering sustained oscillations in the cell growth rate. Cell concentrations oscillated in‐phase with ethanol and acetate concentrations. The amplitude of oscillations depended on the concentration of ethanol in the fermentor. Through multiple oscillatory cycles, the yield ( Y P/S ) and concentration of ethanol decreased, while production of acetate increased. These results suggest that KO11 favorably adapted to improve growth by synthesizing more ATP though acetate production, and recycling NADH by producing more lactate and less ethanol. Implications of these results for strategies to improve ethanol production are described. Biotechnol. Bioeng. 2010;106: 721–730. © 2010 Wiley Periodicals, Inc." @default.
• W2142134221 created "2016-06-24" @default.
• W2142134221 creator A5009504410 @default.
• W2142134221 creator A5022468384 @default.
• W2142134221 creator A5037931742 @default.
• W2142134221 creator A5039218802 @default.
• W2142134221 creator A5083988112 @default.
• W2142134221 date "2010-06-21" @default.
• W2142134221 modified "2023-10-12" @default.
• W2142134221 title "Elucidating mechanisms of solvent toxicity in ethanologenic Escherichia coli" @default.
• W2142134221 cites W1590308370 @default.
• W2142134221 cites W1726118231 @default.
• W2142134221 cites W1766581834 @default.
• W2142134221 cites W1967987135 @default.
• W2142134221 cites W1999804558 @default.
• W2142134221 cites W2002686515 @default.
• W2142134221 cites W2012748008 @default.
• W2142134221 cites W2021362854 @default.
• W2142134221 cites W2024424485 @default.
• W2142134221 cites W2045189668 @default.
• W2142134221 cites W2056937018 @default.
• W2142134221 cites W2078546696 @default.
• W2142134221 cites W2082862043 @default.
• W2142134221 cites W2083693802 @default.
• W2142134221 cites W2092438050 @default.
• W2142134221 cites W2116033756 @default.
• W2142134221 cites W2116735729 @default.
• W2142134221 cites W2121356177 @default.
• W2142134221 cites W2132048431 @default.
• W2142134221 cites W2133234129 @default.
• W2142134221 doi "https://doi.org/10.1002/bit.22743" @default.
• W2142134221 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20564611" @default.
• W2142134221 hasPublicationYear "2010" @default.
• W2142134221 type Work @default.
• W2142134221 sameAs 2142134221 @default.
• W2142134221 citedByCount "16" @default.
• W2142134221 countsByYear W21421342212012 @default.
• W2142134221 countsByYear W21421342212013 @default.
• W2142134221 countsByYear W21421342212014 @default.
• W2142134221 countsByYear W21421342212018 @default.
• W2142134221 countsByYear W21421342212020 @default.
• W2142134221 countsByYear W21421342212022 @default.
• W2142134221 countsByYear W21421342212023 @default.
• W2142134221 crossrefType "journal-article" @default.
• W2142134221 hasAuthorship W2142134221A5009504410 @default.
• W2142134221 hasAuthorship W2142134221A5022468384 @default.
• W2142134221 hasAuthorship W2142134221A5037931742 @default.
• W2142134221 hasAuthorship W2142134221A5039218802 @default.
• W2142134221 hasAuthorship W2142134221A5083988112 @default.
• W2142134221 hasBestOaLocation W21421342211 @default.
• W2142134221 hasConcept C100544194 @default.
• W2142134221 hasConcept C134121241 @default.
• W2142134221 hasConcept C176221332 @default.
• W2142134221 hasConcept C185592680 @default.
• W2142134221 hasConcept C191897082 @default.
• W2142134221 hasConcept C192562407 @default.
• W2142134221 hasConcept C2775920511 @default.
• W2142134221 hasConcept C2777179333 @default.
• W2142134221 hasConcept C2777344606 @default.
• W2142134221 hasConcept C2780161600 @default.
• W2142134221 hasConcept C2781281423 @default.
• W2142134221 hasConcept C30153976 @default.
• W2142134221 hasConcept C523546767 @default.
• W2142134221 hasConcept C53850387 @default.
• W2142134221 hasConcept C54355233 @default.
• W2142134221 hasConcept C55493867 @default.
• W2142134221 hasConcept C65183824 @default.
• W2142134221 hasConcept C86803240 @default.
• W2142134221 hasConcept C98861065 @default.
• W2142134221 hasConceptScore W2142134221C100544194 @default.
• W2142134221 hasConceptScore W2142134221C134121241 @default.
• W2142134221 hasConceptScore W2142134221C176221332 @default.
• W2142134221 hasConceptScore W2142134221C185592680 @default.
• W2142134221 hasConceptScore W2142134221C191897082 @default.
• W2142134221 hasConceptScore W2142134221C192562407 @default.
• W2142134221 hasConceptScore W2142134221C2775920511 @default.
• W2142134221 hasConceptScore W2142134221C2777179333 @default.
• W2142134221 hasConceptScore W2142134221C2777344606 @default.
• W2142134221 hasConceptScore W2142134221C2780161600 @default.
• W2142134221 hasConceptScore W2142134221C2781281423 @default.
• W2142134221 hasConceptScore W2142134221C30153976 @default.
• W2142134221 hasConceptScore W2142134221C523546767 @default.
• W2142134221 hasConceptScore W2142134221C53850387 @default.
• W2142134221 hasConceptScore W2142134221C54355233 @default.
• W2142134221 hasConceptScore W2142134221C55493867 @default.
• W2142134221 hasConceptScore W2142134221C65183824 @default.
• W2142134221 hasConceptScore W2142134221C86803240 @default.
• W2142134221 hasConceptScore W2142134221C98861065 @default.
• W2142134221 hasIssue "5" @default.
• W2142134221 hasLocation W21421342211 @default.
• W2142134221 hasLocation W21421342212 @default.
• W2142134221 hasOpenAccess W2142134221 @default.
• W2142134221 hasPrimaryLocation W21421342211 @default.
• W2142134221 hasRelatedWork W2000497519 @default.
• W2142134221 hasRelatedWork W2027050134 @default.
• W2142134221 hasRelatedWork W2067965407 @default.
• W2142134221 hasRelatedWork W2075218245 @default.
• W2142134221 hasRelatedWork W2163297678 @default.

• next