Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142143757> ?p ?o ?g. }
- W2142143757 endingPage "1560" @default.
- W2142143757 startingPage "1549" @default.
- W2142143757 abstract "Summary Although the major food‐borne pathogen Campylobacter jejuni has been isolated from diverse animal, human and environmental sources, our knowledge of genomic diversity in C. jejuni is based exclusively on human or human food‐chain‐associated isolates. Studies employing multilocus sequence typing have indicated that some clonal complexes are more commonly associated with particular sources. Using comparative genomic hybridization on a collection of 80 isolates representing diverse sources and clonal complexes, we identified a separate clade comprising a group of water/wildlife isolates of C. jejuni with multilocus sequence types uncharacteristic of human food‐chain‐associated isolates. By genome sequencing one representative of this diverse group ( C. jejuni 1336), and a representative of the bank‐vole niche specialist ST‐3704 ( C. jejuni 414), we identified deletions of genomic regions normally carried by human food‐chain‐associated C. jejuni . Several of the deleted regions included genes implicated in chicken colonization or in virulence. Novel genomic insertions contributing to the accessory genomes of strains 1336 and 414 were identified. Comparative analysis using PCR assays indicated that novel regions were common but not ubiquitous among the water/wildlife group of isolates, indicating further genomic diversity among this group, whereas all ST‐3704 isolates carried the same novel accessory regions. While strain 1336 was able to colonize chicks, strain 414 was not, suggesting that regions specifically absent from the genome of strain 414 may play an important role in this common route of Campylobacter infection of humans. We suggest that the genomic divergence observed constitutes evidence of adaptation leading to niche specialization." @default.
- W2142143757 created "2016-06-24" @default.
- W2142143757 creator A5002658344 @default.
- W2142143757 creator A5006037710 @default.
- W2142143757 creator A5012921982 @default.
- W2142143757 creator A5014250652 @default.
- W2142143757 creator A5023116254 @default.
- W2142143757 creator A5024783197 @default.
- W2142143757 creator A5028667380 @default.
- W2142143757 creator A5033115161 @default.
- W2142143757 creator A5035358032 @default.
- W2142143757 creator A5041526116 @default.
- W2142143757 creator A5043390073 @default.
- W2142143757 creator A5045162085 @default.
- W2142143757 creator A5055925102 @default.
- W2142143757 creator A5057145757 @default.
- W2142143757 creator A5080932853 @default.
- W2142143757 date "2011-03-21" @default.
- W2142143757 modified "2023-10-17" @default.
- W2142143757 title "Genomic variations define divergence of water/wildlife‐associated <i>Campylobacter jejuni</i> niche specialists from common clonal complexes" @default.
- W2142143757 cites W104710838 @default.
- W2142143757 cites W1964486506 @default.
- W2142143757 cites W1967917710 @default.
- W2142143757 cites W1977060309 @default.
- W2142143757 cites W1982987923 @default.
- W2142143757 cites W2001161284 @default.
- W2142143757 cites W2002299271 @default.
- W2142143757 cites W2008249012 @default.
- W2142143757 cites W2009615063 @default.
- W2142143757 cites W2012662786 @default.
- W2142143757 cites W2014791123 @default.
- W2142143757 cites W2022339818 @default.
- W2142143757 cites W2029786223 @default.
- W2142143757 cites W2043401453 @default.
- W2142143757 cites W2058327542 @default.
- W2142143757 cites W2059466089 @default.
- W2142143757 cites W2073967559 @default.
- W2142143757 cites W2077524877 @default.
- W2142143757 cites W2089058761 @default.
- W2142143757 cites W2095324004 @default.
- W2142143757 cites W2095991437 @default.
- W2142143757 cites W2097505535 @default.
- W2142143757 cites W2099754631 @default.
- W2142143757 cites W2101220987 @default.
- W2142143757 cites W2103540045 @default.
- W2142143757 cites W2108368634 @default.
- W2142143757 cites W2109607229 @default.
- W2142143757 cites W2111415799 @default.
- W2142143757 cites W2119563151 @default.
- W2142143757 cites W2120904752 @default.
- W2142143757 cites W2123138217 @default.
- W2142143757 cites W2123458093 @default.
- W2142143757 cites W2125302790 @default.
- W2142143757 cites W2129032702 @default.
- W2142143757 cites W2130668158 @default.
- W2142143757 cites W2135180337 @default.
- W2142143757 cites W2142255130 @default.
- W2142143757 cites W2143821568 @default.
- W2142143757 cites W2144225596 @default.
- W2142143757 cites W2146700947 @default.
- W2142143757 cites W2152727327 @default.
- W2142143757 cites W2152821544 @default.
- W2142143757 cites W2153770004 @default.
- W2142143757 cites W2158125655 @default.
- W2142143757 cites W2161084303 @default.
- W2142143757 cites W2161725470 @default.
- W2142143757 cites W2164466614 @default.
- W2142143757 cites W2166422451 @default.
- W2142143757 cites W2167588633 @default.
- W2142143757 cites W2168071402 @default.
- W2142143757 cites W2168134702 @default.
- W2142143757 cites W2170203166 @default.
- W2142143757 cites W2171042562 @default.
- W2142143757 cites W2171524823 @default.
- W2142143757 cites W4238560256 @default.
- W2142143757 doi "https://doi.org/10.1111/j.1462-2920.2011.02461.x" @default.
- W2142143757 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3569610" @default.
- W2142143757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21418497" @default.
- W2142143757 hasPublicationYear "2011" @default.
- W2142143757 type Work @default.
- W2142143757 sameAs 2142143757 @default.
- W2142143757 citedByCount "54" @default.
- W2142143757 countsByYear W21421437572012 @default.
- W2142143757 countsByYear W21421437572013 @default.
- W2142143757 countsByYear W21421437572014 @default.
- W2142143757 countsByYear W21421437572015 @default.
- W2142143757 countsByYear W21421437572016 @default.
- W2142143757 countsByYear W21421437572017 @default.
- W2142143757 countsByYear W21421437572018 @default.
- W2142143757 countsByYear W21421437572019 @default.
- W2142143757 countsByYear W21421437572020 @default.
- W2142143757 countsByYear W21421437572021 @default.
- W2142143757 countsByYear W21421437572022 @default.
- W2142143757 countsByYear W21421437572023 @default.
- W2142143757 crossrefType "journal-article" @default.
- W2142143757 hasAuthorship W2142143757A5002658344 @default.
- W2142143757 hasAuthorship W2142143757A5006037710 @default.
- W2142143757 hasAuthorship W2142143757A5012921982 @default.