Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142146029> ?p ?o ?g. }
- W2142146029 endingPage "2098" @default.
- W2142146029 startingPage "2085" @default.
- W2142146029 abstract "Heterodera glycines is an obligate plant parasite capable of biochemically and developmentally altering its host's cells in order to create a specialized feeding cell. Although the exact mechanism of feeding cell morphogenesis remains a mystery, the nematode's ability to manipulate the plant is thought to be due in part to horizontal gene transfers (HGTs). A bioinformatic screen of the nematode genome has revealed homologues of the genes SNZ and SNO, which comprise a metabolic pathway for the de novo biosynthesis of pyridoxal 5′-phosphate, the active form of vitamin B6 (VB6). Analysis of the 2 genes, HgSNZ and HgSNO, show that they contain nematode-like introns, generate polyadenylated mRNAs, and map to the soybean cyst nematode genetic linkage map, indicating that they are part of the nematode genome. However, gene synteny, protein homology, and phylogenetic evidence suggest prokaryotic origin. This would represent the first case of the HGT of a complete pathway into a nematode or terrestrial animal. VB6 acts as a cofactor in over 140 different enzymes, and recent studies point toward an important role as a potent quencher of reactive oxygen species. With H. glycines’ penchant for acquiring parasitism genes through HGT along with the absence of this pathway in other land-based animals suggests a specific need for VB6 which may involve the parasite–host interaction." @default.
- W2142146029 created "2016-06-24" @default.
- W2142146029 creator A5000908333 @default.
- W2142146029 creator A5024496701 @default.
- W2142146029 creator A5070841403 @default.
- W2142146029 creator A5083740550 @default.
- W2142146029 creator A5085701281 @default.
- W2142146029 creator A5089468828 @default.
- W2142146029 date "2008-07-18" @default.
- W2142146029 modified "2023-09-25" @default.
- W2142146029 title "Analysis of a Horizontally Transferred Pathway Involved in Vitamin B6 Biosynthesis from the Soybean Cyst Nematode Heterodera glycines" @default.
- W2142146029 cites W1525386747 @default.
- W2142146029 cites W1570927267 @default.
- W2142146029 cites W1791475424 @default.
- W2142146029 cites W1868493353 @default.
- W2142146029 cites W1962007356 @default.
- W2142146029 cites W1963864794 @default.
- W2142146029 cites W1964867612 @default.
- W2142146029 cites W1965636522 @default.
- W2142146029 cites W1968547228 @default.
- W2142146029 cites W1974277680 @default.
- W2142146029 cites W1975395158 @default.
- W2142146029 cites W1976162605 @default.
- W2142146029 cites W1980560968 @default.
- W2142146029 cites W1981924974 @default.
- W2142146029 cites W1991524220 @default.
- W2142146029 cites W1993082390 @default.
- W2142146029 cites W1994587807 @default.
- W2142146029 cites W1994624407 @default.
- W2142146029 cites W1996392212 @default.
- W2142146029 cites W1996878825 @default.
- W2142146029 cites W2005029264 @default.
- W2142146029 cites W2008610881 @default.
- W2142146029 cites W2021456660 @default.
- W2142146029 cites W2021762013 @default.
- W2142146029 cites W2024367407 @default.
- W2142146029 cites W2024556021 @default.
- W2142146029 cites W2031354115 @default.
- W2142146029 cites W2033280480 @default.
- W2142146029 cites W2037525379 @default.
- W2142146029 cites W2040885190 @default.
- W2142146029 cites W2043554124 @default.
- W2142146029 cites W2046985589 @default.
- W2142146029 cites W2049392091 @default.
- W2142146029 cites W2053828364 @default.
- W2142146029 cites W2056055173 @default.
- W2142146029 cites W2061393819 @default.
- W2142146029 cites W2062497481 @default.
- W2142146029 cites W2064312495 @default.
- W2142146029 cites W2068352035 @default.
- W2142146029 cites W2081252762 @default.
- W2142146029 cites W2083751016 @default.
- W2142146029 cites W2086137592 @default.
- W2142146029 cites W2089480036 @default.
- W2142146029 cites W2094996657 @default.
- W2142146029 cites W2103546861 @default.
- W2142146029 cites W2105075354 @default.
- W2142146029 cites W2105522288 @default.
- W2142146029 cites W2106882534 @default.
- W2142146029 cites W2114605822 @default.
- W2142146029 cites W2114662953 @default.
- W2142146029 cites W2114910106 @default.
- W2142146029 cites W2116387460 @default.
- W2142146029 cites W2119550888 @default.
- W2142146029 cites W2125121305 @default.
- W2142146029 cites W2126519962 @default.
- W2142146029 cites W2127042732 @default.
- W2142146029 cites W2128114769 @default.
- W2142146029 cites W2129876651 @default.
- W2142146029 cites W2129890743 @default.
- W2142146029 cites W2136280642 @default.
- W2142146029 cites W2139917359 @default.
- W2142146029 cites W2140560927 @default.
- W2142146029 cites W2141242826 @default.
- W2142146029 cites W2146058063 @default.
- W2142146029 cites W2146660498 @default.
- W2142146029 cites W2147807626 @default.
- W2142146029 cites W2149935408 @default.
- W2142146029 cites W2151953515 @default.
- W2142146029 cites W2163027365 @default.
- W2142146029 cites W2167056648 @default.
- W2142146029 cites W2169831209 @default.
- W2142146029 cites W4229822067 @default.
- W2142146029 cites W4230401220 @default.
- W2142146029 cites W4236236547 @default.
- W2142146029 doi "https://doi.org/10.1093/molbev/msn141" @default.
- W2142146029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18586696" @default.
- W2142146029 hasPublicationYear "2008" @default.
- W2142146029 type Work @default.
- W2142146029 sameAs 2142146029 @default.
- W2142146029 citedByCount "42" @default.
- W2142146029 countsByYear W21421460292012 @default.
- W2142146029 countsByYear W21421460292013 @default.
- W2142146029 countsByYear W21421460292014 @default.
- W2142146029 countsByYear W21421460292015 @default.
- W2142146029 countsByYear W21421460292016 @default.
- W2142146029 countsByYear W21421460292017 @default.
- W2142146029 countsByYear W21421460292018 @default.