FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142160158> ?p ?o ?g. }

• W2142160158 endingPage "2742" @default.
• W2142160158 startingPage "2731" @default.
• W2142160158 abstract "Abstract Infection with antimony-resistant Leishmania donovani (SbRLD) induces aggressive pathology in the mammalian hosts as compared with ones with antimony-sensitive L. donovani (SbSLD) infection. SbRLD, but not SbSLD, interacts with TLR2/TLR6 to induce IL-10 by exploiting p50/c-Rel subunits of NF-κB in infected macrophages (Mϕs). Most of the TLRs exploit the universal adaptor protein MyD88 to activate NF-κB. We now show that infection of Mϕs from MyD88−/− mice with SbRLD gave rise to significantly higher intracellular parasite number coupled with elevated IL-10/IL-12 ratio in the culture supernatant as compared with infection in wild type (WT) Mϕs. Τhese attributes were not seen with SbSLD in similar experiments. Further, SbRLD infection upregulated miR-466i, which binds with 3′-untranslated region, leading to the downregulation of MyD88. Infection of MyD88−/− Mϕ or IL-12−/− Mϕ with SbRLD induced IL-10 surge at 4 h, whereas the same in WT Mϕ started from 12 h. Thus, absence of IL-12 in MyD88−/− mice favored early binding of NF-κB subunits to the IL-10 promoter, resulting in IL-10 surge. Infection of MyD88−/− mice with SbRLD showed significantly higher organ parasites coupled with ill-defined and immature hepatic granulomas, whereas in WT mice there were less organ parasites and the granulomas were well defined. From the survival kinetics it was observed that SbRLD-infected MyD88−/− mice died by 60 d postinfection, whereas the WT mice continued to survive. Our results demonstrate that SbRLD has evolved a unique strategy to evade host antileishmanial immune repertoire by manipulating host MyD88 to its advantage." @default.
• W2142160158 created "2016-06-24" @default.
• W2142160158 creator A5001003479 @default.
• W2142160158 creator A5005151809 @default.
• W2142160158 creator A5015413786 @default.
• W2142160158 creator A5024742527 @default.
• W2142160158 creator A5028366364 @default.
• W2142160158 creator A5054138064 @default.
• W2142160158 creator A5056256408 @default.
• W2142160158 creator A5063391602 @default.
• W2142160158 creator A5069240052 @default.
• W2142160158 creator A5074722160 @default.
• W2142160158 date "2015-09-15" @default.
• W2142160158 modified "2023-10-16" @default.
• W2142160158 title "Antimony-Resistant<i>Leishmania donovani</i>Exploits miR-466i To Deactivate Host MyD88 for Regulating IL-10/IL-12 Levels during Early Hours of Infection" @default.
• W2142160158 cites W1490664191 @default.
• W2142160158 cites W1545910465 @default.
• W2142160158 cites W1584100379 @default.
• W2142160158 cites W1655860314 @default.
• W2142160158 cites W1674844815 @default.
• W2142160158 cites W1793115003 @default.
• W2142160158 cites W1855219841 @default.
• W2142160158 cites W1951699079 @default.
• W2142160158 cites W1963542761 @default.
• W2142160158 cites W1968377708 @default.
• W2142160158 cites W1980139593 @default.
• W2142160158 cites W2002583324 @default.
• W2142160158 cites W2023090622 @default.
• W2142160158 cites W2028500185 @default.
• W2142160158 cites W2031184357 @default.
• W2142160158 cites W2039344845 @default.
• W2142160158 cites W2042880168 @default.
• W2142160158 cites W2047752700 @default.
• W2142160158 cites W2048825321 @default.
• W2142160158 cites W2049361955 @default.
• W2142160158 cites W2066954635 @default.
• W2142160158 cites W2071216600 @default.
• W2142160158 cites W2071848825 @default.
• W2142160158 cites W2075223145 @default.
• W2142160158 cites W2075860675 @default.
• W2142160158 cites W2079018560 @default.
• W2142160158 cites W2081480490 @default.
• W2142160158 cites W2102876017 @default.
• W2142160158 cites W2104032434 @default.
• W2142160158 cites W2107121507 @default.
• W2142160158 cites W2109902818 @default.
• W2142160158 cites W2114789036 @default.
• W2142160158 cites W2118850971 @default.
• W2142160158 cites W2120393810 @default.
• W2142160158 cites W2121954054 @default.
• W2142160158 cites W2123986306 @default.
• W2142160158 cites W2124957695 @default.
• W2142160158 cites W2140795762 @default.
• W2142160158 cites W2144120140 @default.
• W2142160158 cites W2158758064 @default.
• W2142160158 cites W2160979794 @default.
• W2142160158 cites W2166510876 @default.
• W2142160158 cites W2168350246 @default.
• W2142160158 cites W2169865777 @default.
• W2142160158 cites W2170781554 @default.
• W2142160158 doi "https://doi.org/10.4049/jimmunol.1402585" @default.
• W2142160158 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26283478" @default.
• W2142160158 hasPublicationYear "2015" @default.
• W2142160158 type Work @default.
• W2142160158 sameAs 2142160158 @default.
• W2142160158 citedByCount "27" @default.
• W2142160158 countsByYear W21421601582016 @default.
• W2142160158 countsByYear W21421601582017 @default.
• W2142160158 countsByYear W21421601582018 @default.
• W2142160158 countsByYear W21421601582019 @default.
• W2142160158 countsByYear W21421601582020 @default.
• W2142160158 countsByYear W21421601582021 @default.
• W2142160158 countsByYear W21421601582022 @default.
• W2142160158 countsByYear W21421601582023 @default.
• W2142160158 crossrefType "journal-article" @default.
• W2142160158 hasAuthorship W2142160158A5001003479 @default.
• W2142160158 hasAuthorship W2142160158A5005151809 @default.
• W2142160158 hasAuthorship W2142160158A5015413786 @default.
• W2142160158 hasAuthorship W2142160158A5024742527 @default.
• W2142160158 hasAuthorship W2142160158A5028366364 @default.
• W2142160158 hasAuthorship W2142160158A5054138064 @default.
• W2142160158 hasAuthorship W2142160158A5056256408 @default.
• W2142160158 hasAuthorship W2142160158A5063391602 @default.
• W2142160158 hasAuthorship W2142160158A5069240052 @default.
• W2142160158 hasAuthorship W2142160158A5074722160 @default.
• W2142160158 hasBestOaLocation W21421601581 @default.
• W2142160158 hasConcept C104317684 @default.
• W2142160158 hasConcept C127561419 @default.
• W2142160158 hasConcept C136449434 @default.
• W2142160158 hasConcept C136764020 @default.
• W2142160158 hasConcept C153911025 @default.
• W2142160158 hasConcept C187316574 @default.
• W2142160158 hasConcept C203014093 @default.
• W2142160158 hasConcept C2776555147 @default.
• W2142160158 hasConcept C2778689377 @default.
• W2142160158 hasConcept C2780931953 @default.
• W2142160158 hasConcept C2781092759 @default.
• W2142160158 hasConcept C2781236682 @default.

• next