FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142166685> ?p ?o ?g. }

• W2142166685 endingPage "e1002603" @default.
• W2142166685 startingPage "e1002603" @default.
• W2142166685 abstract "Traditionally the gene expression pathway has been regarded as being comprised of independent steps, from RNA transcription to protein translation. To date there is increasing evidence of coupling between the different processes of the pathway, specifically between transcription and splicing. To study the interplay between these processes we derived a transcription-splicing integrated network. The nodes of the network included experimentally verified human proteins belonging to three groups of regulators: transcription factors, splicing factors and kinases. The nodes were wired by instances of predicted transcriptional and alternative splicing regulation. Analysis of the network indicated a pervasive cross-regulation among the nodes; specifically, splicing factors are significantly more connected by alternative splicing regulatory edges relative to the two other subgroups, while transcription factors are more extensively controlled by transcriptional regulation. Furthermore, we found that splicing factors are the most regulated of the three regulatory groups and are subject to extensive combinatorial control by alternative splicing and transcriptional regulation. Consistent with the network results, our bioinformatics analyses showed that the subgroup of kinases have the highest density of predicted phosphorylation sites. Overall, our systematic study reveals that an organizing principle in the logic of integrated networks favor the regulation of regulatory proteins by the specific regulation they conduct. Based on these results, we propose a new regulatory paradigm postulating that gene expression regulation of the master regulators in the cell is predominantly achieved by cross-regulation." @default.
• W2142166685 created "2016-06-24" @default.
• W2142166685 creator A5051324698 @default.
• W2142166685 creator A5068778085 @default.
• W2142166685 creator A5071783473 @default.
• W2142166685 date "2012-07-26" @default.
• W2142166685 modified "2023-09-27" @default.
• W2142166685 title "An Integrated Regulatory Network Reveals Pervasive Cross-Regulation among Transcription and Splicing Factors" @default.
• W2142166685 cites W1504845338 @default.
• W2142166685 cites W1792685479 @default.
• W2142166685 cites W1966413945 @default.
• W2142166685 cites W1968569455 @default.
• W2142166685 cites W1969209329 @default.
• W2142166685 cites W1971846931 @default.
• W2142166685 cites W1974898488 @default.
• W2142166685 cites W1975797969 @default.
• W2142166685 cites W1980389572 @default.
• W2142166685 cites W1988971922 @default.
• W2142166685 cites W1992371761 @default.
• W2142166685 cites W1994026170 @default.
• W2142166685 cites W1997254455 @default.
• W2142166685 cites W2006931677 @default.
• W2142166685 cites W2010122622 @default.
• W2142166685 cites W2011983814 @default.
• W2142166685 cites W2012827002 @default.
• W2142166685 cites W2021018226 @default.
• W2142166685 cites W2021632119 @default.
• W2142166685 cites W2024036230 @default.
• W2142166685 cites W2026358891 @default.
• W2142166685 cites W2026671856 @default.
• W2142166685 cites W2030056549 @default.
• W2142166685 cites W2030205108 @default.
• W2142166685 cites W2035542044 @default.
• W2142166685 cites W2036583346 @default.
• W2142166685 cites W2038963685 @default.
• W2142166685 cites W2044117548 @default.
• W2142166685 cites W2053003053 @default.
• W2142166685 cites W2054649620 @default.
• W2142166685 cites W2057710277 @default.
• W2142166685 cites W2069327448 @default.
• W2142166685 cites W2069898971 @default.
• W2142166685 cites W2070815451 @default.
• W2142166685 cites W2077941487 @default.
• W2142166685 cites W2078655896 @default.
• W2142166685 cites W2085656056 @default.
• W2142166685 cites W2086233060 @default.
• W2142166685 cites W2097220641 @default.
• W2142166685 cites W2098412979 @default.
• W2142166685 cites W2101296410 @default.
• W2142166685 cites W2102025585 @default.
• W2142166685 cites W2102304447 @default.
• W2142166685 cites W2104715883 @default.
• W2142166685 cites W2106309105 @default.
• W2142166685 cites W2107881958 @default.
• W2142166685 cites W2109063364 @default.
• W2142166685 cites W2109248504 @default.
• W2142166685 cites W2110868158 @default.
• W2142166685 cites W2111295518 @default.
• W2142166685 cites W2114246266 @default.
• W2142166685 cites W2119986079 @default.
• W2142166685 cites W2120881407 @default.
• W2142166685 cites W2122683221 @default.
• W2142166685 cites W2123950820 @default.
• W2142166685 cites W2128551987 @default.
• W2142166685 cites W2135112382 @default.
• W2142166685 cites W2135185213 @default.
• W2142166685 cites W2141411086 @default.
• W2142166685 cites W2142676859 @default.
• W2142166685 cites W2150107170 @default.
• W2142166685 cites W2150812970 @default.
• W2142166685 cites W2151478689 @default.
• W2142166685 cites W2157338021 @default.
• W2142166685 cites W2159274692 @default.
• W2142166685 cites W2159730169 @default.
• W2142166685 cites W2159993062 @default.
• W2142166685 cites W2162727919 @default.
• W2142166685 cites W2164683872 @default.
• W2142166685 cites W2165660562 @default.
• W2142166685 cites W2165997146 @default.
• W2142166685 cites W2166021928 @default.
• W2142166685 cites W2168783124 @default.
• W2142166685 cites W2444402051 @default.
• W2142166685 cites W324535036 @default.
• W2142166685 doi "https://doi.org/10.1371/journal.pcbi.1002603" @default.
• W2142166685 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3405991" @default.
• W2142166685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22844237" @default.
• W2142166685 hasPublicationYear "2012" @default.
• W2142166685 type Work @default.
• W2142166685 sameAs 2142166685 @default.
• W2142166685 citedByCount "15" @default.
• W2142166685 countsByYear W21421666852013 @default.
• W2142166685 countsByYear W21421666852014 @default.
• W2142166685 countsByYear W21421666852015 @default.
• W2142166685 countsByYear W21421666852016 @default.
• W2142166685 countsByYear W21421666852019 @default.
• W2142166685 countsByYear W21421666852020 @default.
• W2142166685 countsByYear W21421666852021 @default.
• W2142166685 countsByYear W21421666852022 @default.

• next