FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142201438> ?p ?o ?g. }

• W2142201438 endingPage "378" @default.
• W2142201438 startingPage "372" @default.
• W2142201438 abstract "The contribution of central pharmacodynamic mechanisms to the pathogenesis of motor fluctuations in advanced Parkinson's disease was studied in 29 patients by evaluating their acute response to intravenously injected. levodopa. While the threshold dose for an antiparkinsonian effect did not change, that for induction of dyskinesia showed a progressive reduction in 4 groups: (1) levodopa-naive patients, (2) those with a stable response to oral administration, and (3) those with wearing-off or (4) on-off fluctuations. Concomitantly, the therapeutic window for levodopa narrowed and the levodopa dose—antiparkinsonian response slope increased. The antiparkinsonian threshold dose correlated best with duration of symptoms; the dyskinesia threshold dose, therapeutic window, and dose-response slope related most closely with the duration of levodopa treatment. The differing dose-response profiles for the antiparkinosonian and dyskinetic effects suggest involvement of Septemberarate pharmacological mechanisms. The present results, taken together with previous observations that the wearing-off phenomenon responds promptly to plasma levodopa stabilization while on-off fluctuations tend to diminish over several days, suggest that postsynaptic modifications, presumably at the receptor level, serve as the major determinant for the increasing difficulty with optimal dose adjustment and motor fluctuations, especially of the on-off type, which complicate levodopa therapy of patients with advance Parkinson's disease." @default.
• W2142201438 created "2016-06-24" @default.
• W2142201438 creator A5002403864 @default.
• W2142201438 creator A5010035939 @default.
• W2142201438 creator A5014715397 @default.
• W2142201438 creator A5042095130 @default.
• W2142201438 creator A5060517208 @default.
• W2142201438 creator A5082424410 @default.
• W2142201438 date "1988-09-01" @default.
• W2142201438 modified "2023-10-02" @default.
• W2142201438 title "Motor fluctuations in Parkinson's disease: Central pathophysiological mechanisms, part II" @default.
• W2142201438 cites W1963721516 @default.
• W2142201438 cites W1975179530 @default.
• W2142201438 cites W1976749972 @default.
• W2142201438 cites W1981609060 @default.
• W2142201438 cites W1982538657 @default.
• W2142201438 cites W1993578402 @default.
• W2142201438 cites W1995011868 @default.
• W2142201438 cites W2008119031 @default.
• W2142201438 cites W2010255219 @default.
• W2142201438 cites W2011986497 @default.
• W2142201438 cites W2013487743 @default.
• W2142201438 cites W2013929683 @default.
• W2142201438 cites W2043037767 @default.
• W2142201438 cites W2049945970 @default.
• W2142201438 cites W2051414078 @default.
• W2142201438 cites W2056327020 @default.
• W2142201438 cites W2056496790 @default.
• W2142201438 cites W2063628608 @default.
• W2142201438 cites W2064996887 @default.
• W2142201438 cites W2067529527 @default.
• W2142201438 cites W2070191357 @default.
• W2142201438 cites W2071948878 @default.
• W2142201438 cites W2072270685 @default.
• W2142201438 cites W2076281963 @default.
• W2142201438 cites W2076668541 @default.
• W2142201438 cites W2078409015 @default.
• W2142201438 cites W2078692158 @default.
• W2142201438 cites W2079428348 @default.
• W2142201438 cites W2089546113 @default.
• W2142201438 cites W2091977887 @default.
• W2142201438 cites W2094543793 @default.
• W2142201438 cites W2127586686 @default.
• W2142201438 cites W2143800493 @default.
• W2142201438 cites W2156607549 @default.
• W2142201438 cites W2165407029 @default.
• W2142201438 cites W2321544597 @default.
• W2142201438 cites W2328300816 @default.
• W2142201438 cites W2337142316 @default.
• W2142201438 cites W2340133307 @default.
• W2142201438 cites W4255433669 @default.
• W2142201438 doi "https://doi.org/10.1002/ana.410240304" @default.
• W2142201438 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3228271" @default.
• W2142201438 hasPublicationYear "1988" @default.
• W2142201438 type Work @default.
• W2142201438 sameAs 2142201438 @default.
• W2142201438 citedByCount "282" @default.
• W2142201438 countsByYear W21422014382012 @default.
• W2142201438 countsByYear W21422014382013 @default.
• W2142201438 countsByYear W21422014382014 @default.
• W2142201438 countsByYear W21422014382015 @default.
• W2142201438 countsByYear W21422014382016 @default.
• W2142201438 countsByYear W21422014382017 @default.
• W2142201438 countsByYear W21422014382018 @default.
• W2142201438 countsByYear W21422014382019 @default.
• W2142201438 countsByYear W21422014382020 @default.
• W2142201438 countsByYear W21422014382021 @default.
• W2142201438 countsByYear W21422014382022 @default.
• W2142201438 countsByYear W21422014382023 @default.
• W2142201438 crossrefType "journal-article" @default.
• W2142201438 hasAuthorship W2142201438A5002403864 @default.
• W2142201438 hasAuthorship W2142201438A5010035939 @default.
• W2142201438 hasAuthorship W2142201438A5014715397 @default.
• W2142201438 hasAuthorship W2142201438A5042095130 @default.
• W2142201438 hasAuthorship W2142201438A5060517208 @default.
• W2142201438 hasAuthorship W2142201438A5082424410 @default.
• W2142201438 hasConcept C10162356 @default.
• W2142201438 hasConcept C111113717 @default.
• W2142201438 hasConcept C112705442 @default.
• W2142201438 hasConcept C126322002 @default.
• W2142201438 hasConcept C15744967 @default.
• W2142201438 hasConcept C169760540 @default.
• W2142201438 hasConcept C2779134260 @default.
• W2142201438 hasConcept C2779734285 @default.
• W2142201438 hasConcept C2780304432 @default.
• W2142201438 hasConcept C2780405171 @default.
• W2142201438 hasConcept C42219234 @default.
• W2142201438 hasConcept C46622094 @default.
• W2142201438 hasConcept C71924100 @default.
• W2142201438 hasConcept C98274493 @default.
• W2142201438 hasConceptScore W2142201438C10162356 @default.
• W2142201438 hasConceptScore W2142201438C111113717 @default.
• W2142201438 hasConceptScore W2142201438C112705442 @default.
• W2142201438 hasConceptScore W2142201438C126322002 @default.
• W2142201438 hasConceptScore W2142201438C15744967 @default.
• W2142201438 hasConceptScore W2142201438C169760540 @default.
• W2142201438 hasConceptScore W2142201438C2779134260 @default.
• W2142201438 hasConceptScore W2142201438C2779734285 @default.

• next