FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142206343> ?p ?o ?g. }

• W2142206343 endingPage "175" @default.
• W2142206343 startingPage "145" @default.
• W2142206343 abstract "We have discussed in the previous sections the recent progress made toward elucidating the regulatory mechanism of perforin gene transcription and the domain structure of the perforin molecule. It appears that the expression of perforin is, at least partially, controlled at the transcription level through the interaction between killer cell-specific cis- and trans- acting factors. One of such cognate pairs, NF-P motif (an EBS-homologous motif) and NF-P2 (a killer cell-specific DNA-binding protein), has been described. The regulatory mechanism of gene transcription, however, is likely to involve multiple factors which act in a coordinated fashion to bring about the most efficient expression of perforin limited strictly to activated killer lymphocytes. Through studies using synthetic peptides and recombinant perforins, it has been suggested that the N-terminal region of the perforin molecule is an important, though not the only, domain responsible for the lytic activity. Further studies are warranted to elucidate the role(s) of other potential amphiphilic structures located in the central portion of the perforin molecule in the overall pore-forming activity. The molecular basis underlying the resistance of killer lymphocytes to perforin-mediated lysis still remains an open question. Preliminary results, however, suggest that the surface protein(s) restricted to killer cells may account for their self-protection against perforin. Based on recent studies using perforin-deficient mice, the involvement of perforin in lymphocyte-mediated cytolysis both in vivo and in vitro has been confirmed. Two functional roles, a direct (lytic) and an indirect (endocytosis enhancer; conduit), both of which may contribute critically to the cell-killing event can be attributed to perforin. The fact that lymphocytes may also employ perforin-independent killing mechanism(s), e.g. Fas-dependent pathway, is beyond the scope of this review. There is, nevertheless, no doubt that these alternative cytolytic mechanisms may also play important roles in immune effector and/or regulatory responses associated with killer lymphocytes. Obviously, we are still a long way from concluding on the functional relevance of each individual cytolytic mechanism seen in different physiopathological situations. Suffice it to say, however, that a wealth of information on lymphocyte-mediated killing has already emerged through the multidisciplinary efforts conducted in our and other laboratories that promise to further dissect this complicated event in the years to come." @default.
• W2142206343 created "2016-06-24" @default.
• W2142206343 creator A5011123052 @default.
• W2142206343 creator A5027668084 @default.
• W2142206343 creator A5039271498 @default.
• W2142206343 date "1995-08-01" @default.
• W2142206343 modified "2023-10-15" @default.
• W2142206343 title "Perforin and Lymphocyte-mediated Cytolysis" @default.
• W2142206343 cites W1495097924 @default.
• W2142206343 cites W1513153150 @default.
• W2142206343 cites W1517394132 @default.
• W2142206343 cites W1518087011 @default.
• W2142206343 cites W1518612448 @default.
• W2142206343 cites W1523029070 @default.
• W2142206343 cites W1539212319 @default.
• W2142206343 cites W1546719435 @default.
• W2142206343 cites W1561613355 @default.
• W2142206343 cites W1563729327 @default.
• W2142206343 cites W1584004718 @default.
• W2142206343 cites W1591083200 @default.
• W2142206343 cites W1591446606 @default.
• W2142206343 cites W1601870423 @default.
• W2142206343 cites W1610364856 @default.
• W2142206343 cites W1623235930 @default.
• W2142206343 cites W168029340 @default.
• W2142206343 cites W1715952970 @default.
• W2142206343 cites W1816140862 @default.
• W2142206343 cites W1924889542 @default.
• W2142206343 cites W1925242062 @default.
• W2142206343 cites W1937061404 @default.
• W2142206343 cites W1939896456 @default.
• W2142206343 cites W1965008348 @default.
• W2142206343 cites W1965130012 @default.
• W2142206343 cites W1966200872 @default.
• W2142206343 cites W1966370175 @default.
• W2142206343 cites W1967848800 @default.
• W2142206343 cites W1969746584 @default.
• W2142206343 cites W1970001272 @default.
• W2142206343 cites W1975549159 @default.
• W2142206343 cites W1979395931 @default.
• W2142206343 cites W1981182552 @default.
• W2142206343 cites W1982892464 @default.
• W2142206343 cites W1983954064 @default.
• W2142206343 cites W1984957290 @default.
• W2142206343 cites W1985620373 @default.
• W2142206343 cites W1986202661 @default.
• W2142206343 cites W1987918502 @default.
• W2142206343 cites W1988730582 @default.
• W2142206343 cites W1988905999 @default.
• W2142206343 cites W1989754171 @default.
• W2142206343 cites W1991212304 @default.
• W2142206343 cites W1992919569 @default.
• W2142206343 cites W1994288430 @default.
• W2142206343 cites W1996616758 @default.
• W2142206343 cites W1998120252 @default.
• W2142206343 cites W1998847155 @default.
• W2142206343 cites W2000267785 @default.
• W2142206343 cites W2001664656 @default.
• W2142206343 cites W2002733542 @default.
• W2142206343 cites W2002783893 @default.
• W2142206343 cites W2004353384 @default.
• W2142206343 cites W2004645606 @default.
• W2142206343 cites W2005874504 @default.
• W2142206343 cites W2007836961 @default.
• W2142206343 cites W2008448390 @default.
• W2142206343 cites W2009689312 @default.
• W2142206343 cites W2014767363 @default.
• W2142206343 cites W2017419438 @default.
• W2142206343 cites W2020976163 @default.
• W2142206343 cites W2022842834 @default.
• W2142206343 cites W2023359882 @default.
• W2142206343 cites W2025002024 @default.
• W2142206343 cites W2028711398 @default.
• W2142206343 cites W2028776659 @default.
• W2142206343 cites W2029743627 @default.
• W2142206343 cites W2031250216 @default.
• W2142206343 cites W2032360303 @default.
• W2142206343 cites W2033661159 @default.
• W2142206343 cites W2034760582 @default.
• W2142206343 cites W2039985913 @default.
• W2142206343 cites W2041054392 @default.
• W2142206343 cites W2043178618 @default.
• W2142206343 cites W2046195792 @default.
• W2142206343 cites W2049213988 @default.
• W2142206343 cites W2049956305 @default.
• W2142206343 cites W2051659591 @default.
• W2142206343 cites W2054539901 @default.
• W2142206343 cites W2056158101 @default.
• W2142206343 cites W2056924500 @default.
• W2142206343 cites W2058809763 @default.
• W2142206343 cites W2059931536 @default.
• W2142206343 cites W2062052846 @default.
• W2142206343 cites W2063420993 @default.
• W2142206343 cites W2064706357 @default.
• W2142206343 cites W2068092923 @default.
• W2142206343 cites W2069187924 @default.
• W2142206343 cites W2072663421 @default.
• W2142206343 cites W2073858677 @default.

• next