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- W2142214302 endingPage "409" @default.
- W2142214302 startingPage "387" @default.
- W2142214302 abstract "The renal medulla produces concentrated urine through the generation of an osmotic gradient that progressively increases from the cortico-medullary boundary to the inner medullary tip. In the outer medulla, the osmolality gradient arises principally from vigorous active transport of NaCl, without accompanying water, from the thick ascending limbs of short- and long-looped nephrons. In the inner medulla, the source of the osmotic gradient has not been identified. Recently, there have been important advances in our understanding of key components of the urine-concentrating mechanism, including (a) better understanding of the regulation of water, urea, and sodium transport proteins; (b) better resolution of the anatomical relationships in the medulla; and (c) improvements in mathematical modeling of the urine-concentrating mechanism. Continued experimental investigation of signaling pathways regulating transepithelial transport, both in normal animals and in knockout mice, and incorporation of the resulting information into mathematical simulations may help to more fully elucidate the mechanism for concentrating urine in the inner medulla." @default.
- W2142214302 created "2016-06-24" @default.
- W2142214302 creator A5014014770 @default.
- W2142214302 creator A5039580452 @default.
- W2142214302 date "2014-02-10" @default.
- W2142214302 modified "2023-09-30" @default.
- W2142214302 title "Advances in Understanding the Urine-Concentrating Mechanism" @default.
- W2142214302 cites W1022286328 @default.
- W2142214302 cites W1520077165 @default.
- W2142214302 cites W1746005614 @default.
- W2142214302 cites W1789176484 @default.
- W2142214302 cites W185848793 @default.
- W2142214302 cites W1866380084 @default.
- W2142214302 cites W1880084651 @default.
- W2142214302 cites W1965419276 @default.
- W2142214302 cites W1966102491 @default.
- W2142214302 cites W1966694021 @default.
- W2142214302 cites W1977136755 @default.
- W2142214302 cites W1978085375 @default.
- W2142214302 cites W1979213982 @default.
- W2142214302 cites W1979720774 @default.
- W2142214302 cites W1982162713 @default.
- W2142214302 cites W1985901022 @default.
- W2142214302 cites W1987442187 @default.
- W2142214302 cites W1988506390 @default.
- W2142214302 cites W1992439000 @default.
- W2142214302 cites W1997374036 @default.
- W2142214302 cites W1999027802 @default.
- W2142214302 cites W1999297869 @default.
- W2142214302 cites W2000454415 @default.
- W2142214302 cites W2003766936 @default.
- W2142214302 cites W2004573417 @default.
- W2142214302 cites W2006992689 @default.
- W2142214302 cites W2008069830 @default.
- W2142214302 cites W2014540603 @default.
- W2142214302 cites W2015053721 @default.
- W2142214302 cites W201875857 @default.
- W2142214302 cites W2021549898 @default.
- W2142214302 cites W2025026783 @default.
- W2142214302 cites W2026153574 @default.
- W2142214302 cites W2033107260 @default.
- W2142214302 cites W2035468774 @default.
- W2142214302 cites W2044090529 @default.
- W2142214302 cites W2055612791 @default.
- W2142214302 cites W2059594778 @default.
- W2142214302 cites W2063549176 @default.
- W2142214302 cites W2067743343 @default.
- W2142214302 cites W2068248654 @default.
- W2142214302 cites W2069303405 @default.
- W2142214302 cites W2070855370 @default.
- W2142214302 cites W2071306297 @default.
- W2142214302 cites W2072198819 @default.
- W2142214302 cites W2072620267 @default.
- W2142214302 cites W2074936851 @default.
- W2142214302 cites W2076063805 @default.
- W2142214302 cites W2084158810 @default.
- W2142214302 cites W2085784194 @default.
- W2142214302 cites W2089068874 @default.
- W2142214302 cites W2092944093 @default.
- W2142214302 cites W2096400415 @default.
- W2142214302 cites W2101531367 @default.
- W2142214302 cites W2103938607 @default.
- W2142214302 cites W2104024716 @default.
- W2142214302 cites W2106651741 @default.
- W2142214302 cites W2108450175 @default.
- W2142214302 cites W2110685988 @default.
- W2142214302 cites W2112525791 @default.
- W2142214302 cites W2113800313 @default.
- W2142214302 cites W2114078055 @default.
- W2142214302 cites W2116902706 @default.
- W2142214302 cites W2117193737 @default.
- W2142214302 cites W2121011489 @default.
- W2142214302 cites W2122959376 @default.
- W2142214302 cites W2124414657 @default.
- W2142214302 cites W2129294026 @default.
- W2142214302 cites W2130994367 @default.
- W2142214302 cites W2131632133 @default.
- W2142214302 cites W2132704954 @default.
- W2142214302 cites W2135374199 @default.
- W2142214302 cites W2142884729 @default.
- W2142214302 cites W2144009346 @default.
- W2142214302 cites W2145489740 @default.
- W2142214302 cites W2145633875 @default.
- W2142214302 cites W2145807001 @default.
- W2142214302 cites W2146739117 @default.
- W2142214302 cites W2148470566 @default.
- W2142214302 cites W2150377321 @default.
- W2142214302 cites W2154357598 @default.
- W2142214302 cites W2157369420 @default.
- W2142214302 cites W2161009969 @default.
- W2142214302 cites W2161354173 @default.
- W2142214302 cites W2167561506 @default.
- W2142214302 cites W2167609426 @default.
- W2142214302 cites W2168137664 @default.
- W2142214302 cites W2170604230 @default.
- W2142214302 cites W2188551092 @default.
- W2142214302 cites W2189069938 @default.
- W2142214302 cites W2210451193 @default.