FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142215766> ?p ?o ?g. }

• W2142215766 endingPage "912" @default.
• W2142215766 startingPage "907" @default.
• W2142215766 abstract "Gonadotroph adenomas may exhibit qualitative and quantitative defects in gonadotropin biosynthesis and secretion. Hypersecretion of immunoreactive FSH dimers by these adenomas occurs frequently; however, it has not been known whether this FSH is biologically active. Using the granulosa cell aromatase bioassay and a highly specific immunoradiometric assay for FSH, we studied the serum bioactivity and bio- to immunoactivity (B/I) ratios of 14 men with FSH-secreting adenomas and compared these values to those of 11 age-matched normal men. In addition, three adenoma patients received TRH (400 μg, iv). The mean basal serum FSH level (international units per L), as measured by both bio- and immunoassays, and the FSH B/I ratios were significantly higher (P < 0.02, by Kolmogorov-Smirnov test) in the adenoma patients than in normal men (mean ± sem; adenoma patients: bioactivity, 68.8 ± 10.4; immunoreactivity, 34.8 ± 13.7; B/I ratio, 3.4 ± 0.6; normal men: bioactivity, 5.8 ± 1.2; immunoreactivity, 6.4 ± 0.8; B/I ratio, 0.90 ± 0.1). Both bio- and immunoactive FSH rose after TRH injection, resulting in maintenance of the B/I (mean ± SEM; pre-TRH: bio-FSH, 63.7 ± 22.4; immuno-FSH, 28.0 ± 14.1; B/I ratio, 2.8 ± 1.2; post-TRH: bio-FSH, 125.6 ± 42.7; immuno-FSH, 45.8 ± 21.8; B/I ratio, 3.5 ± 1.6). When gonadotroph adenoma cells from three separate patients were cultured and their conditioned media (n = 3) studied, relatively large amounts of both bio- and immuno-FSH were detected. Furthermore, the major isoelectric profile of bio-FSH (pH 4.9–3.0) in the conditioned medium from two such adenomas was shown by chromatofocusing to be comparable to that of purified human pituitary FSH (pH 5.2–3.6). We conclude that gonadotroph adenomas in men secrete FSH that is biologically active, both basally and in response to TRH." @default.
• W2142215766 created "2016-06-24" @default.
• W2142215766 creator A5006681163 @default.
• W2142215766 creator A5025178988 @default.
• W2142215766 creator A5025270511 @default.
• W2142215766 creator A5076118083 @default.
• W2142215766 creator A5086295199 @default.
• W2142215766 creator A5087639196 @default.
• W2142215766 date "1990-10-01" @default.
• W2142215766 modified "2023-10-18" @default.
• W2142215766 title "Gonadotroph Adenomas in Men Produce Biologically Active Follicle-Stimulating Hormone*" @default.
• W2142215766 cites W110628693 @default.
• W2142215766 cites W1565160468 @default.
• W2142215766 cites W19029990 @default.
• W2142215766 cites W1970413305 @default.
• W2142215766 cites W1982626008 @default.
• W2142215766 cites W1985239266 @default.
• W2142215766 cites W1996533815 @default.
• W2142215766 cites W2004861430 @default.
• W2142215766 cites W2010560163 @default.
• W2142215766 cites W2010872713 @default.
• W2142215766 cites W2019125479 @default.
• W2142215766 cites W2019961183 @default.
• W2142215766 cites W2024120978 @default.
• W2142215766 cites W2024881534 @default.
• W2142215766 cites W2031157579 @default.
• W2142215766 cites W2032280488 @default.
• W2142215766 cites W2043304428 @default.
• W2142215766 cites W2058977748 @default.
• W2142215766 cites W2066922718 @default.
• W2142215766 cites W2075504948 @default.
• W2142215766 cites W2079882365 @default.
• W2142215766 cites W2080388300 @default.
• W2142215766 cites W2087272305 @default.
• W2142215766 cites W2092094647 @default.
• W2142215766 cites W2126388567 @default.
• W2142215766 cites W2127290405 @default.
• W2142215766 cites W2165534557 @default.
• W2142215766 cites W2171642341 @default.
• W2142215766 cites W2419433936 @default.
• W2142215766 cites W2432545515 @default.
• W2142215766 doi "https://doi.org/10.1210/jcem-71-4-907" @default.
• W2142215766 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2119391" @default.
• W2142215766 hasPublicationYear "1990" @default.
• W2142215766 type Work @default.
• W2142215766 sameAs 2142215766 @default.
• W2142215766 citedByCount "49" @default.
• W2142215766 countsByYear W21422157662012 @default.
• W2142215766 countsByYear W21422157662013 @default.
• W2142215766 countsByYear W21422157662014 @default.
• W2142215766 countsByYear W21422157662015 @default.
• W2142215766 countsByYear W21422157662016 @default.
• W2142215766 countsByYear W21422157662017 @default.
• W2142215766 countsByYear W21422157662018 @default.
• W2142215766 countsByYear W21422157662021 @default.
• W2142215766 countsByYear W21422157662022 @default.
• W2142215766 crossrefType "journal-article" @default.
• W2142215766 hasAuthorship W2142215766A5006681163 @default.
• W2142215766 hasAuthorship W2142215766A5025178988 @default.
• W2142215766 hasAuthorship W2142215766A5025270511 @default.
• W2142215766 hasAuthorship W2142215766A5076118083 @default.
• W2142215766 hasAuthorship W2142215766A5086295199 @default.
• W2142215766 hasAuthorship W2142215766A5087639196 @default.
• W2142215766 hasConcept C116073593 @default.
• W2142215766 hasConcept C126322002 @default.
• W2142215766 hasConcept C134018914 @default.
• W2142215766 hasConcept C176685330 @default.
• W2142215766 hasConcept C202751555 @default.
• W2142215766 hasConcept C2777428134 @default.
• W2142215766 hasConcept C2778024521 @default.
• W2142215766 hasConcept C2778575703 @default.
• W2142215766 hasConcept C2778758028 @default.
• W2142215766 hasConcept C2778782382 @default.
• W2142215766 hasConcept C2779279165 @default.
• W2142215766 hasConcept C2779306644 @default.
• W2142215766 hasConcept C55493867 @default.
• W2142215766 hasConcept C71315377 @default.
• W2142215766 hasConcept C71924100 @default.
• W2142215766 hasConcept C86803240 @default.
• W2142215766 hasConceptScore W2142215766C116073593 @default.
• W2142215766 hasConceptScore W2142215766C126322002 @default.
• W2142215766 hasConceptScore W2142215766C134018914 @default.
• W2142215766 hasConceptScore W2142215766C176685330 @default.
• W2142215766 hasConceptScore W2142215766C202751555 @default.
• W2142215766 hasConceptScore W2142215766C2777428134 @default.
• W2142215766 hasConceptScore W2142215766C2778024521 @default.
• W2142215766 hasConceptScore W2142215766C2778575703 @default.
• W2142215766 hasConceptScore W2142215766C2778758028 @default.
• W2142215766 hasConceptScore W2142215766C2778782382 @default.
• W2142215766 hasConceptScore W2142215766C2779279165 @default.
• W2142215766 hasConceptScore W2142215766C2779306644 @default.
• W2142215766 hasConceptScore W2142215766C55493867 @default.
• W2142215766 hasConceptScore W2142215766C71315377 @default.
• W2142215766 hasConceptScore W2142215766C71924100 @default.
• W2142215766 hasConceptScore W2142215766C86803240 @default.
• W2142215766 hasIssue "4" @default.
• W2142215766 hasLocation W21422157661 @default.
• W2142215766 hasLocation W21422157662 @default.

• next