Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142242016> ?p ?o ?g. }
- W2142242016 endingPage "5427" @default.
- W2142242016 startingPage "5421" @default.
- W2142242016 abstract "Abstract Polarization of T cells involves reorientation of the microtubule organizing center (MTOC). Because activated ERK is localized at the immunological synapse, we investigated its role by showing that ERK activation is important for MTOC polarization. Suspecting that ERK phosphorylates a regulator of microtubules, we next focused on stathmin, a known ERK substrate. Our work indicates that during T cell activation, ERK is recruited to the synapse, allowing it to phosphorylate stathmin molecules near the immunological synapse. Supporting an important role of stathmin phosphorylation in T cell activation, we showed that T cell activation results in increased microtubule growth rate dependent on the presence of stathmin. The significance of this finding was demonstrated by results showing that CTLs from stathmin−/− mice displayed defective MTOC polarization and defective target cell cytolysis. These data implicate stathmin as a regulator of the microtubule network during T cell activation." @default.
- W2142242016 created "2016-06-24" @default.
- W2142242016 creator A5005523678 @default.
- W2142242016 creator A5062448287 @default.
- W2142242016 creator A5078706922 @default.
- W2142242016 creator A5078781783 @default.
- W2142242016 creator A5090663440 @default.
- W2142242016 date "2012-06-01" @default.
- W2142242016 modified "2023-09-27" @default.
- W2142242016 title "Stathmin Regulates Microtubule Dynamics and Microtubule Organizing Center Polarization in Activated T Cells" @default.
- W2142242016 cites W1532352879 @default.
- W2142242016 cites W1574286840 @default.
- W2142242016 cites W1589707604 @default.
- W2142242016 cites W1595127999 @default.
- W2142242016 cites W1621186721 @default.
- W2142242016 cites W1671937407 @default.
- W2142242016 cites W1677807424 @default.
- W2142242016 cites W1920982543 @default.
- W2142242016 cites W1928165021 @default.
- W2142242016 cites W1959677146 @default.
- W2142242016 cites W1968273066 @default.
- W2142242016 cites W1969475953 @default.
- W2142242016 cites W1980331527 @default.
- W2142242016 cites W1982306166 @default.
- W2142242016 cites W1983237268 @default.
- W2142242016 cites W1985499212 @default.
- W2142242016 cites W1987240796 @default.
- W2142242016 cites W1987955440 @default.
- W2142242016 cites W1994078986 @default.
- W2142242016 cites W1994737830 @default.
- W2142242016 cites W2016109341 @default.
- W2142242016 cites W2021607362 @default.
- W2142242016 cites W2034439664 @default.
- W2142242016 cites W2041857614 @default.
- W2142242016 cites W2042496256 @default.
- W2142242016 cites W2054709003 @default.
- W2142242016 cites W2055314875 @default.
- W2142242016 cites W2057819204 @default.
- W2142242016 cites W2061598672 @default.
- W2142242016 cites W2061752926 @default.
- W2142242016 cites W2065240922 @default.
- W2142242016 cites W2081227240 @default.
- W2142242016 cites W2082501089 @default.
- W2142242016 cites W2084127936 @default.
- W2142242016 cites W2086831735 @default.
- W2142242016 cites W2096234619 @default.
- W2142242016 cites W2113144687 @default.
- W2142242016 cites W2116669977 @default.
- W2142242016 cites W2129558898 @default.
- W2142242016 cites W2145957054 @default.
- W2142242016 cites W2155823821 @default.
- W2142242016 cites W2171690383 @default.
- W2142242016 doi "https://doi.org/10.4049/jimmunol.1200242" @default.
- W2142242016 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3358357" @default.
- W2142242016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22529300" @default.
- W2142242016 hasPublicationYear "2012" @default.
- W2142242016 type Work @default.
- W2142242016 sameAs 2142242016 @default.
- W2142242016 citedByCount "40" @default.
- W2142242016 countsByYear W21422420162013 @default.
- W2142242016 countsByYear W21422420162014 @default.
- W2142242016 countsByYear W21422420162015 @default.
- W2142242016 countsByYear W21422420162016 @default.
- W2142242016 countsByYear W21422420162017 @default.
- W2142242016 countsByYear W21422420162018 @default.
- W2142242016 countsByYear W21422420162019 @default.
- W2142242016 countsByYear W21422420162020 @default.
- W2142242016 countsByYear W21422420162021 @default.
- W2142242016 countsByYear W21422420162022 @default.
- W2142242016 countsByYear W21422420162023 @default.
- W2142242016 crossrefType "journal-article" @default.
- W2142242016 hasAuthorship W2142242016A5005523678 @default.
- W2142242016 hasAuthorship W2142242016A5062448287 @default.
- W2142242016 hasAuthorship W2142242016A5078706922 @default.
- W2142242016 hasAuthorship W2142242016A5078781783 @default.
- W2142242016 hasAuthorship W2142242016A5090663440 @default.
- W2142242016 hasBestOaLocation W21422420161 @default.
- W2142242016 hasConcept C104317684 @default.
- W2142242016 hasConcept C10447061 @default.
- W2142242016 hasConcept C104672736 @default.
- W2142242016 hasConcept C11960822 @default.
- W2142242016 hasConcept C1491633281 @default.
- W2142242016 hasConcept C178666793 @default.
- W2142242016 hasConcept C181912034 @default.
- W2142242016 hasConcept C185592680 @default.
- W2142242016 hasConcept C19317047 @default.
- W2142242016 hasConcept C203014093 @default.
- W2142242016 hasConcept C20418707 @default.
- W2142242016 hasConcept C2776090121 @default.
- W2142242016 hasConcept C2778654611 @default.
- W2142242016 hasConcept C29537977 @default.
- W2142242016 hasConcept C55493867 @default.
- W2142242016 hasConcept C57074206 @default.
- W2142242016 hasConcept C6929976 @default.
- W2142242016 hasConcept C86803240 @default.
- W2142242016 hasConcept C8891405 @default.
- W2142242016 hasConcept C95444343 @default.
- W2142242016 hasConcept C9756297 @default.