FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142242182> ?p ?o ?g. }

• W2142242182 endingPage "6582" @default.
• W2142242182 startingPage "6576" @default.
• W2142242182 abstract "There is considerable evidence that sphingosine kinases play a key role in cancer progression, which might involve positive selection of cancer cells that have been provided with a survival and growth advantage as a consequence of overexpression of the enzyme. Therefore, inhibitors of sphingosine kinase represent a novel class of compounds that have potential as anticancer agents. Poor inhibitor potency is a major issue that has precluded successful translation of these compounds into the clinic. However, recent discoveries have shown that sphingosine kinase 1 is an allosteric enzyme and that some inhibitors offer improved effectiveness by inducing proteasomal degradation of the enzyme or having nanomolar potency. Herein, we provide a perspective about these recent developments and highlight the importance of translating basic pharmacologic and biochemical findings on sphingosine kinase into new drug discovery programs for treatment of cancer." @default.
• W2142242182 created "2016-06-24" @default.
• W2142242182 creator A5004530946 @default.
• W2142242182 creator A5023834954 @default.
• W2142242182 creator A5060561968 @default.
• W2142242182 date "2011-10-30" @default.
• W2142242182 modified "2023-10-14" @default.
• W2142242182 title "Sphingosine Kinase Inhibitors and Cancer: Seeking the Golden Sword of Hercules" @default.
• W2142242182 cites W1964438952 @default.
• W2142242182 cites W1973573934 @default.
• W2142242182 cites W1983079076 @default.
• W2142242182 cites W1995093204 @default.
• W2142242182 cites W1996605319 @default.
• W2142242182 cites W1997458456 @default.
• W2142242182 cites W2002694320 @default.
• W2142242182 cites W2017410696 @default.
• W2142242182 cites W2018146992 @default.
• W2142242182 cites W2020730385 @default.
• W2142242182 cites W2023293937 @default.
• W2142242182 cites W2047607345 @default.
• W2142242182 cites W2051485704 @default.
• W2142242182 cites W2063869544 @default.
• W2142242182 cites W2069141563 @default.
• W2142242182 cites W2078794107 @default.
• W2142242182 cites W2088008750 @default.
• W2142242182 cites W2091414871 @default.
• W2142242182 cites W2097202436 @default.
• W2142242182 cites W2101672301 @default.
• W2142242182 cites W2105250575 @default.
• W2142242182 cites W2106242725 @default.
• W2142242182 cites W2107132781 @default.
• W2142242182 cites W2109827751 @default.
• W2142242182 cites W2117773251 @default.
• W2142242182 cites W2149615364 @default.
• W2142242182 cites W2154089780 @default.
• W2142242182 cites W2156502916 @default.
• W2142242182 cites W2159775348 @default.
• W2142242182 cites W2163885294 @default.
• W2142242182 doi "https://doi.org/10.1158/0008-5472.can-11-2364" @default.
• W2142242182 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3206172" @default.
• W2142242182 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21940750" @default.
• W2142242182 hasPublicationYear "2011" @default.
• W2142242182 type Work @default.
• W2142242182 sameAs 2142242182 @default.
• W2142242182 citedByCount "79" @default.
• W2142242182 countsByYear W21422421822012 @default.
• W2142242182 countsByYear W21422421822013 @default.
• W2142242182 countsByYear W21422421822014 @default.
• W2142242182 countsByYear W21422421822015 @default.
• W2142242182 countsByYear W21422421822016 @default.
• W2142242182 countsByYear W21422421822017 @default.
• W2142242182 countsByYear W21422421822018 @default.
• W2142242182 countsByYear W21422421822019 @default.
• W2142242182 countsByYear W21422421822020 @default.
• W2142242182 countsByYear W21422421822021 @default.
• W2142242182 countsByYear W21422421822022 @default.
• W2142242182 countsByYear W21422421822023 @default.
• W2142242182 crossrefType "journal-article" @default.
• W2142242182 hasAuthorship W2142242182A5004530946 @default.
• W2142242182 hasAuthorship W2142242182A5023834954 @default.
• W2142242182 hasAuthorship W2142242182A5060561968 @default.
• W2142242182 hasBestOaLocation W21422421821 @default.
• W2142242182 hasConcept C121608353 @default.
• W2142242182 hasConcept C166342909 @default.
• W2142242182 hasConcept C170493617 @default.
• W2142242182 hasConcept C181199279 @default.
• W2142242182 hasConcept C184235292 @default.
• W2142242182 hasConcept C2776596873 @default.
• W2142242182 hasConcept C2777550365 @default.
• W2142242182 hasConcept C2777700496 @default.
• W2142242182 hasConcept C2778703144 @default.
• W2142242182 hasConcept C54355233 @default.
• W2142242182 hasConcept C55493867 @default.
• W2142242182 hasConcept C74187038 @default.
• W2142242182 hasConcept C86803240 @default.
• W2142242182 hasConcept C96232424 @default.
• W2142242182 hasConcept C98274493 @default.
• W2142242182 hasConceptScore W2142242182C121608353 @default.
• W2142242182 hasConceptScore W2142242182C166342909 @default.
• W2142242182 hasConceptScore W2142242182C170493617 @default.
• W2142242182 hasConceptScore W2142242182C181199279 @default.
• W2142242182 hasConceptScore W2142242182C184235292 @default.
• W2142242182 hasConceptScore W2142242182C2776596873 @default.
• W2142242182 hasConceptScore W2142242182C2777550365 @default.
• W2142242182 hasConceptScore W2142242182C2777700496 @default.
• W2142242182 hasConceptScore W2142242182C2778703144 @default.
• W2142242182 hasConceptScore W2142242182C54355233 @default.
• W2142242182 hasConceptScore W2142242182C55493867 @default.
• W2142242182 hasConceptScore W2142242182C74187038 @default.
• W2142242182 hasConceptScore W2142242182C86803240 @default.
• W2142242182 hasConceptScore W2142242182C96232424 @default.
• W2142242182 hasConceptScore W2142242182C98274493 @default.
• W2142242182 hasIssue "21" @default.
• W2142242182 hasLocation W21422421821 @default.
• W2142242182 hasLocation W21422421822 @default.
• W2142242182 hasLocation W21422421823 @default.
• W2142242182 hasLocation W21422421824 @default.
• W2142242182 hasOpenAccess W2142242182 @default.

• next