Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142244149> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2142244149 endingPage "7" @default.
- W2142244149 startingPage "1391" @default.
- W2142244149 abstract "We characterized three human brain tumor cell lines (D54, HBT-20, and HBT-28) with respect to resistance to etoposide (VP-16), a topoisomerase II-reactive drug. All three cell lines were inherently resistant to VP-16 when compared to other human cell lines, with D54 showing the greatest resistance using colony formation assays. Resistance to VP-16 has been attributed to decreased drug uptake and changes in topoisomerase II; however, drug uptake and topoisomerase II protein levels (immunoblot) were no lower in D54 than in HBT-20 and HBT-28, cell lines relatively more sensitive to VP-16. More to the point, measurement of topoisomerase II-mediated DNA cleavage of cellular DNA after treatment with VP-16 showed that the topoisomerase II in these cells was active. These data indicate mechanisms other than those attributable to decreased drug uptake or altered topoisomerase II exist for clinical resistance to VP-16. VP-16-induced DNA cleavage has been associated with apoptosis in some cell lines; however, neither DNA laddering nor morphological changes characteristic of apoptosis were detected in these cell lines after treatment with VP-16. Bcl-2 and mutant p53 were present in these cells. Either of these conditions can prevent apoptosis and could explain a dissociation between the proximal mediator of VP-16-induced cytotoxicity (topoisomerase II-DNA complex formation) and cellular death." @default.
- W2142244149 created "2016-06-24" @default.
- W2142244149 creator A5011494265 @default.
- W2142244149 creator A5024971593 @default.
- W2142244149 creator A5045196434 @default.
- W2142244149 creator A5069036413 @default.
- W2142244149 date "1995-11-01" @default.
- W2142244149 modified "2023-09-23" @default.
- W2142244149 title "Expression of topoisomerase II, bcl-2, and p53 in three human brain tumor cell lines and their possible relationship to intrinsic resistance to etoposide." @default.
- W2142244149 cites W1486520062 @default.
- W2142244149 cites W1514682355 @default.
- W2142244149 cites W1543443055 @default.
- W2142244149 cites W1545495395 @default.
- W2142244149 cites W1545715398 @default.
- W2142244149 cites W1555798239 @default.
- W2142244149 cites W1587229711 @default.
- W2142244149 cites W1592664042 @default.
- W2142244149 cites W1594804854 @default.
- W2142244149 cites W1645990259 @default.
- W2142244149 cites W1847864430 @default.
- W2142244149 cites W1854896859 @default.
- W2142244149 cites W1979319210 @default.
- W2142244149 cites W2000646975 @default.
- W2142244149 cites W2053211776 @default.
- W2142244149 cites W2054322117 @default.
- W2142244149 cites W2055349083 @default.
- W2142244149 cites W2057257609 @default.
- W2142244149 cites W2061172591 @default.
- W2142244149 cites W2078458079 @default.
- W2142244149 cites W2078581194 @default.
- W2142244149 cites W2101647884 @default.
- W2142244149 cites W2134793597 @default.
- W2142244149 cites W2139360111 @default.
- W2142244149 cites W2149538015 @default.
- W2142244149 cites W2153712534 @default.
- W2142244149 cites W2167349611 @default.
- W2142244149 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9815936" @default.
- W2142244149 hasPublicationYear "1995" @default.
- W2142244149 type Work @default.
- W2142244149 sameAs 2142244149 @default.
- W2142244149 citedByCount "5" @default.
- W2142244149 countsByYear W21422441492019 @default.
- W2142244149 crossrefType "journal-article" @default.
- W2142244149 hasAuthorship W2142244149A5011494265 @default.
- W2142244149 hasAuthorship W2142244149A5024971593 @default.
- W2142244149 hasAuthorship W2142244149A5045196434 @default.
- W2142244149 hasAuthorship W2142244149A5069036413 @default.
- W2142244149 hasConcept C143425029 @default.
- W2142244149 hasConcept C147897179 @default.
- W2142244149 hasConcept C153911025 @default.
- W2142244149 hasConcept C155878803 @default.
- W2142244149 hasConcept C190283241 @default.
- W2142244149 hasConcept C2776694085 @default.
- W2142244149 hasConcept C2778119113 @default.
- W2142244149 hasConcept C2778616834 @default.
- W2142244149 hasConcept C31573885 @default.
- W2142244149 hasConcept C43759708 @default.
- W2142244149 hasConcept C502942594 @default.
- W2142244149 hasConcept C54355233 @default.
- W2142244149 hasConcept C552990157 @default.
- W2142244149 hasConcept C55493867 @default.
- W2142244149 hasConcept C81885089 @default.
- W2142244149 hasConcept C86803240 @default.
- W2142244149 hasConceptScore W2142244149C143425029 @default.
- W2142244149 hasConceptScore W2142244149C147897179 @default.
- W2142244149 hasConceptScore W2142244149C153911025 @default.
- W2142244149 hasConceptScore W2142244149C155878803 @default.
- W2142244149 hasConceptScore W2142244149C190283241 @default.
- W2142244149 hasConceptScore W2142244149C2776694085 @default.
- W2142244149 hasConceptScore W2142244149C2778119113 @default.
- W2142244149 hasConceptScore W2142244149C2778616834 @default.
- W2142244149 hasConceptScore W2142244149C31573885 @default.
- W2142244149 hasConceptScore W2142244149C43759708 @default.
- W2142244149 hasConceptScore W2142244149C502942594 @default.
- W2142244149 hasConceptScore W2142244149C54355233 @default.
- W2142244149 hasConceptScore W2142244149C552990157 @default.
- W2142244149 hasConceptScore W2142244149C55493867 @default.
- W2142244149 hasConceptScore W2142244149C81885089 @default.
- W2142244149 hasConceptScore W2142244149C86803240 @default.
- W2142244149 hasIssue "11" @default.
- W2142244149 hasLocation W21422441491 @default.
- W2142244149 hasOpenAccess W2142244149 @default.
- W2142244149 hasPrimaryLocation W21422441491 @default.
- W2142244149 hasRelatedWork W1559053841 @default.
- W2142244149 hasRelatedWork W1965224165 @default.
- W2142244149 hasRelatedWork W1971988781 @default.
- W2142244149 hasRelatedWork W1979297684 @default.
- W2142244149 hasRelatedWork W2016433185 @default.
- W2142244149 hasRelatedWork W2031879715 @default.
- W2142244149 hasRelatedWork W2068981603 @default.
- W2142244149 hasRelatedWork W2079839615 @default.
- W2142244149 hasRelatedWork W2296428487 @default.
- W2142244149 hasRelatedWork W587475530 @default.
- W2142244149 hasVolume "1" @default.
- W2142244149 isParatext "false" @default.
- W2142244149 isRetracted "false" @default.
- W2142244149 magId "2142244149" @default.
- W2142244149 workType "article" @default.