Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142258608> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2142258608 endingPage "375" @default.
- W2142258608 startingPage "371" @default.
- W2142258608 abstract "Omeprazole is a proton pump inhibitor for the treatment of gastric acid-related disorders. In recent years, reports of dermatitis upon exposure to omeprazole during manufacture have been noted.To present diagnostic findings in workers who reported suspected hypersensitivity reactions resulting from occupational exposure to omeprazole.Ninety-six workers exposed to omeprazole during the manufacturing process underwent investigation by the AstraZeneca Occupational Health Centre (Södertälje, Sweden) for suspected allergy. All subjects underwent a lymphocyte transformation test (LTT) and a skin test within 6 months of the clinical reaction. Predictive tests on guinea-pigs were conducted to establish omeprazole's sensitizing potential.Thirty-one subjects with clinical symptoms had a positive LTT result. Twenty-eight subjects had positive patch test results; of these, 23 also had a positive LTT result (sensitivity of the LTT: 82%). Fifty-six subjects had negative patch test results; 46 of these had a negative LTT result (specificity: 82%). All subjects who underwent prick testing (n = 18) had negative results. Delayed contact hypersensitivity was observed in 18 of 20 test animals.These findings confirm the risk of sensitization to omeprazole from occupational exposure. They are of importance for the development of new formulations of omeprazole, or its enantiomers, in light of the potential for inducing skin allergy." @default.
- W2142258608 created "2016-06-24" @default.
- W2142258608 creator A5006005139 @default.
- W2142258608 creator A5012475809 @default.
- W2142258608 creator A5031787583 @default.
- W2142258608 creator A5053240117 @default.
- W2142258608 creator A5077291872 @default.
- W2142258608 creator A5091832049 @default.
- W2142258608 date "2014-10-14" @default.
- W2142258608 modified "2023-10-18" @default.
- W2142258608 title "Sensitization to omeprazole in the occupational setting" @default.
- W2142258608 cites W1753071495 @default.
- W2142258608 cites W1971589835 @default.
- W2142258608 cites W1983904427 @default.
- W2142258608 cites W1987130491 @default.
- W2142258608 cites W1987876444 @default.
- W2142258608 cites W2009943290 @default.
- W2142258608 cites W2019322318 @default.
- W2142258608 cites W2038748459 @default.
- W2142258608 cites W2041687187 @default.
- W2142258608 cites W2061412603 @default.
- W2142258608 cites W2092346402 @default.
- W2142258608 cites W2128547050 @default.
- W2142258608 cites W4251106039 @default.
- W2142258608 doi "https://doi.org/10.1111/cod.12305" @default.
- W2142258608 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25310916" @default.
- W2142258608 hasPublicationYear "2014" @default.
- W2142258608 type Work @default.
- W2142258608 sameAs 2142258608 @default.
- W2142258608 citedByCount "14" @default.
- W2142258608 countsByYear W21422586082014 @default.
- W2142258608 countsByYear W21422586082015 @default.
- W2142258608 countsByYear W21422586082016 @default.
- W2142258608 countsByYear W21422586082017 @default.
- W2142258608 countsByYear W21422586082018 @default.
- W2142258608 countsByYear W21422586082019 @default.
- W2142258608 countsByYear W21422586082020 @default.
- W2142258608 crossrefType "journal-article" @default.
- W2142258608 hasAuthorship W2142258608A5006005139 @default.
- W2142258608 hasAuthorship W2142258608A5012475809 @default.
- W2142258608 hasAuthorship W2142258608A5031787583 @default.
- W2142258608 hasAuthorship W2142258608A5053240117 @default.
- W2142258608 hasAuthorship W2142258608A5077291872 @default.
- W2142258608 hasAuthorship W2142258608A5091832049 @default.
- W2142258608 hasConcept C126322002 @default.
- W2142258608 hasConcept C140764562 @default.
- W2142258608 hasConcept C16005928 @default.
- W2142258608 hasConcept C203014093 @default.
- W2142258608 hasConcept C207480886 @default.
- W2142258608 hasConcept C2776217527 @default.
- W2142258608 hasConcept C2777498785 @default.
- W2142258608 hasConcept C2778091633 @default.
- W2142258608 hasConcept C2781025758 @default.
- W2142258608 hasConcept C71924100 @default.
- W2142258608 hasConcept C90924648 @default.
- W2142258608 hasConceptScore W2142258608C126322002 @default.
- W2142258608 hasConceptScore W2142258608C140764562 @default.
- W2142258608 hasConceptScore W2142258608C16005928 @default.
- W2142258608 hasConceptScore W2142258608C203014093 @default.
- W2142258608 hasConceptScore W2142258608C207480886 @default.
- W2142258608 hasConceptScore W2142258608C2776217527 @default.
- W2142258608 hasConceptScore W2142258608C2777498785 @default.
- W2142258608 hasConceptScore W2142258608C2778091633 @default.
- W2142258608 hasConceptScore W2142258608C2781025758 @default.
- W2142258608 hasConceptScore W2142258608C71924100 @default.
- W2142258608 hasConceptScore W2142258608C90924648 @default.
- W2142258608 hasFunder F4320307770 @default.
- W2142258608 hasIssue "6" @default.
- W2142258608 hasLocation W21422586081 @default.
- W2142258608 hasLocation W21422586082 @default.
- W2142258608 hasOpenAccess W2142258608 @default.
- W2142258608 hasPrimaryLocation W21422586081 @default.
- W2142258608 hasRelatedWork W1692469601 @default.
- W2142258608 hasRelatedWork W1966545836 @default.
- W2142258608 hasRelatedWork W2076013314 @default.
- W2142258608 hasRelatedWork W2093394777 @default.
- W2142258608 hasRelatedWork W2098476153 @default.
- W2142258608 hasRelatedWork W2105498110 @default.
- W2142258608 hasRelatedWork W2142258608 @default.
- W2142258608 hasRelatedWork W2332428898 @default.
- W2142258608 hasRelatedWork W4205107155 @default.
- W2142258608 hasRelatedWork W4210850534 @default.
- W2142258608 hasVolume "71" @default.
- W2142258608 isParatext "false" @default.
- W2142258608 isRetracted "false" @default.
- W2142258608 magId "2142258608" @default.
- W2142258608 workType "article" @default.