FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142273844> ?p ?o ?g. }

• W2142273844 endingPage "581" @default.
• W2142273844 startingPage "565" @default.
• W2142273844 abstract "A large population of amacrine cells in the retina are thought to use GABA as an inhibitory neurotransmitter in their synaptic interactions within the inner plexiform layer. However, little is known about their synaptic targets; the neurons that express the receptors for GABA have not been clearly identified. Recently, the GABAA receptor has been isolated and antibodies have been raised against it. These antibodies have proven useful for the immunocytochemical localization of the receptor, and two brief reports describing the distribution of GABAA receptor immunoreactivity in the retina have appeared (Richards et al., 1987; Mariani et al., 1987). We used a monoclonal antibody (62-3G1) against the GABAA receptor to study the retina of the New World primate Saimiri sciureus. Labeled somata were found in the inner nuclear layer (INL) and ganglion cell layer (GCL). The staining was confined to what appeared to be the cell's plasmalemma and small cytoplasmic granules. Most of the labeled neurons in the INL had small somata (5-7 microns in diameter) located at the vitreal edge of the layer. They arborized in two laminae (approximately 2 and 4) of inner plexiform layer (IPL). Ventral to the optic disc (2.5 mm) they comprised 29% of the cells present. A few of the labeled neurons appeared to be interplexiform cells or flat bipolar cells, with labeled processes that extended into both the IPL and the inner half of the outer plexiform layer. In the GCL, the labeled somata were among the largest present (13-20 microns in diameter), and 2.5 mm ventral to the optic disc they made up 15% of the cells present. Experiments in which immunoreactive somata were retrogradely labeled following the injection of fluorescent tracers into the optic tract provided a conclusive demonstration that some of the immunoreactive somata were ganglion cells. The antibody often labeled their axons in the optic fiber layer. This suggests that the GABAA receptors are transported anterogradely to the retinal terminal fields. The dendrites of the immunoreactive ganglion cells extended into the 2 laminae of labeled processes in the IPL, and their primary dendritic arbors were, at any given eccentricity, quite similar in appearance. This homogeneity suggests that they comprise a particular subset of the ganglion cells. Sections simultaneously labeled with the monoclonal antibody against the GABAA receptor and antisera against either L-glutamic acid decarboxylase (GAD) or GABA revealed that the GAD/GABA was distributed much more widely in the IPL than the GABAA receptor.(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
• W2142273844 created "2016-06-24" @default.
• W2142273844 creator A5054191371 @default.
• W2142273844 creator A5061359578 @default.
• W2142273844 creator A5064941788 @default.
• W2142273844 creator A5088168529 @default.
• W2142273844 creator A5088395099 @default.
• W2142273844 date "1989-06-01" @default.
• W2142273844 modified "2023-09-24" @default.
• W2142273844 title "Immunohistochemical localization of GABA_Areceptors in the retina of the new world primate<i>Saimiri sciureus</i>" @default.
• W2142273844 cites W12789555 @default.
• W2142273844 cites W1528288950 @default.
• W2142273844 cites W1559326290 @default.
• W2142273844 cites W1592243888 @default.
• W2142273844 cites W1608212407 @default.
• W2142273844 cites W1628508588 @default.
• W2142273844 cites W1635851992 @default.
• W2142273844 cites W1755159888 @default.
• W2142273844 cites W1825905345 @default.
• W2142273844 cites W1890868908 @default.
• W2142273844 cites W1966376255 @default.
• W2142273844 cites W1966979931 @default.
• W2142273844 cites W1967715965 @default.
• W2142273844 cites W1978054401 @default.
• W2142273844 cites W1980945615 @default.
• W2142273844 cites W1982182964 @default.
• W2142273844 cites W1985867674 @default.
• W2142273844 cites W1986978718 @default.
• W2142273844 cites W1988992139 @default.
• W2142273844 cites W1989431255 @default.
• W2142273844 cites W1992224713 @default.
• W2142273844 cites W1997093524 @default.
• W2142273844 cites W1998265309 @default.
• W2142273844 cites W1998624786 @default.
• W2142273844 cites W2002598925 @default.
• W2142273844 cites W2003075703 @default.
• W2142273844 cites W2005349051 @default.
• W2142273844 cites W2005861965 @default.
• W2142273844 cites W2006558781 @default.
• W2142273844 cites W2008051797 @default.
• W2142273844 cites W2009731382 @default.
• W2142273844 cites W2013512495 @default.
• W2142273844 cites W2019990453 @default.
• W2142273844 cites W2028066020 @default.
• W2142273844 cites W2028248419 @default.
• W2142273844 cites W2028674613 @default.
• W2142273844 cites W2029300670 @default.
• W2142273844 cites W2030602458 @default.
• W2142273844 cites W2032672456 @default.
• W2142273844 cites W2033244316 @default.
• W2142273844 cites W2040283480 @default.
• W2142273844 cites W2042478664 @default.
• W2142273844 cites W2043119637 @default.
• W2142273844 cites W2050009950 @default.
• W2142273844 cites W2050357426 @default.
• W2142273844 cites W2054424607 @default.
• W2142273844 cites W2056038780 @default.
• W2142273844 cites W2056119107 @default.
• W2142273844 cites W2056597974 @default.
• W2142273844 cites W2057782586 @default.
• W2142273844 cites W2058125953 @default.
• W2142273844 cites W2064588683 @default.
• W2142273844 cites W2065717702 @default.
• W2142273844 cites W2066277308 @default.
• W2142273844 cites W2066881364 @default.
• W2142273844 cites W2067209735 @default.
• W2142273844 cites W2067506301 @default.
• W2142273844 cites W2069776045 @default.
• W2142273844 cites W2070948566 @default.
• W2142273844 cites W2072825187 @default.
• W2142273844 cites W2074772940 @default.
• W2142273844 cites W2076163188 @default.
• W2142273844 cites W2078663010 @default.
• W2142273844 cites W2079305834 @default.
• W2142273844 cites W2079774938 @default.
• W2142273844 cites W2080214516 @default.
• W2142273844 cites W2081453098 @default.
• W2142273844 cites W2083000712 @default.
• W2142273844 cites W2084977537 @default.
• W2142273844 cites W2089338590 @default.
• W2142273844 cites W2093811657 @default.
• W2142273844 cites W2097948012 @default.
• W2142273844 cites W2122087911 @default.
• W2142273844 cites W2123799480 @default.
• W2142273844 cites W2128319263 @default.
• W2142273844 cites W2130918570 @default.
• W2142273844 cites W2156212448 @default.
• W2142273844 cites W2156268266 @default.
• W2142273844 cites W2160131677 @default.
• W2142273844 cites W2236242713 @default.
• W2142273844 cites W2406388519 @default.
• W2142273844 cites W2409170450 @default.
• W2142273844 cites W2410097514 @default.
• W2142273844 cites W2439795249 @default.
• W2142273844 cites W2495344055 @default.
• W2142273844 cites W29188351 @default.
• W2142273844 doi "https://doi.org/10.1017/s0952523800003503" @default.
• W2142273844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2562111" @default.

• next