FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142300957> ?p ?o ?g. }

• W2142300957 endingPage "253" @default.
• W2142300957 startingPage "241" @default.
• W2142300957 abstract "Disseminated gonococcal infection (DGI) is a rare but serious complication caused by the spread of Neisseria gonorrhoeae in the human host. Gonococci associated with DGI mainly express the outer membrane protein PorBIA that binds to the scavenger receptor expressed on endothelial cells (SREC-I) and mediates bacterial uptake. We recently demonstrated that this interaction relies on intact membrane rafts that acquire SREC-I upon attachment of gonococci and initiates the signalling cascade that finally leads to the uptake of gonococci in epithelial cells. In this study, we analysed the role of sphingomyelinases and their breakdown product ceramide. Gonococcal infection induced increased levels of ceramide that was enriched at bacterial attachment sites. Interestingly, neutral but not acid sphingomyelinase was mandatory for PorBIA -mediated invasion into host cells. Neutral sphingomyelinase was required to recruit the PI3 kinase to caveolin and thereby activates the PI3 kinase-dependent downstream signalling leading to bacterial uptake. Thus, this study elucidates the initial signalling processes of bacterial invasion during DGI and demonstrates a novel role for neutral sphingomyelinase in the course of bacterial infections." @default.
• W2142300957 created "2016-06-24" @default.
• W2142300957 creator A5004462514 @default.
• W2142300957 creator A5004523892 @default.
• W2142300957 creator A5019230382 @default.
• W2142300957 creator A5020858927 @default.
• W2142300957 creator A5022547631 @default.
• W2142300957 creator A5024587025 @default.
• W2142300957 creator A5027253304 @default.
• W2142300957 creator A5057212370 @default.
• W2142300957 date "2014-10-31" @default.
• W2142300957 modified "2023-10-01" @default.
• W2142300957 title "Neutral sphingomyelinase 2 is a key factor for PorB-dependent invasion of<i>N</i><i>eisseria gonorrhoeae</i>" @default.
• W2142300957 cites W1256777839 @default.
• W2142300957 cites W1823104567 @default.
• W2142300957 cites W1897865243 @default.
• W2142300957 cites W1973416270 @default.
• W2142300957 cites W1977371793 @default.
• W2142300957 cites W1979767486 @default.
• W2142300957 cites W1981444453 @default.
• W2142300957 cites W1982954591 @default.
• W2142300957 cites W1987172632 @default.
• W2142300957 cites W1998865212 @default.
• W2142300957 cites W2005218497 @default.
• W2142300957 cites W2009635211 @default.
• W2142300957 cites W2012394768 @default.
• W2142300957 cites W2015616869 @default.
• W2142300957 cites W2022497999 @default.
• W2142300957 cites W2057551818 @default.
• W2142300957 cites W2061486289 @default.
• W2142300957 cites W2062376915 @default.
• W2142300957 cites W2069285405 @default.
• W2142300957 cites W2078957898 @default.
• W2142300957 cites W2079559905 @default.
• W2142300957 cites W2079814213 @default.
• W2142300957 cites W2081578928 @default.
• W2142300957 cites W2094522158 @default.
• W2142300957 cites W2095447604 @default.
• W2142300957 cites W2097105956 @default.
• W2142300957 cites W2097807909 @default.
• W2142300957 cites W2111128412 @default.
• W2142300957 cites W2111450162 @default.
• W2142300957 cites W2112987667 @default.
• W2142300957 cites W2134152012 @default.
• W2142300957 cites W2144865169 @default.
• W2142300957 cites W2148670577 @default.
• W2142300957 cites W2152354057 @default.
• W2142300957 cites W2153366148 @default.
• W2142300957 cites W2167884805 @default.
• W2142300957 cites W2169876093 @default.
• W2142300957 doi "https://doi.org/10.1111/cmi.12361" @default.
• W2142300957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25224994" @default.
• W2142300957 hasPublicationYear "2014" @default.
• W2142300957 type Work @default.
• W2142300957 sameAs 2142300957 @default.
• W2142300957 citedByCount "22" @default.
• W2142300957 countsByYear W21423009572016 @default.
• W2142300957 countsByYear W21423009572017 @default.
• W2142300957 countsByYear W21423009572018 @default.
• W2142300957 countsByYear W21423009572019 @default.
• W2142300957 countsByYear W21423009572020 @default.
• W2142300957 countsByYear W21423009572021 @default.
• W2142300957 countsByYear W21423009572022 @default.
• W2142300957 countsByYear W21423009572023 @default.
• W2142300957 crossrefType "journal-article" @default.
• W2142300957 hasAuthorship W2142300957A5004462514 @default.
• W2142300957 hasAuthorship W2142300957A5004523892 @default.
• W2142300957 hasAuthorship W2142300957A5019230382 @default.
• W2142300957 hasAuthorship W2142300957A5020858927 @default.
• W2142300957 hasAuthorship W2142300957A5022547631 @default.
• W2142300957 hasAuthorship W2142300957A5024587025 @default.
• W2142300957 hasAuthorship W2142300957A5027253304 @default.
• W2142300957 hasAuthorship W2142300957A5057212370 @default.
• W2142300957 hasBestOaLocation W21423009571 @default.
• W2142300957 hasConcept C104317684 @default.
• W2142300957 hasConcept C127561419 @default.
• W2142300957 hasConcept C146587185 @default.
• W2142300957 hasConcept C184235292 @default.
• W2142300957 hasConcept C190283241 @default.
• W2142300957 hasConcept C2777851122 @default.
• W2142300957 hasConcept C2779166590 @default.
• W2142300957 hasConcept C2781457462 @default.
• W2142300957 hasConcept C41625074 @default.
• W2142300957 hasConcept C547475151 @default.
• W2142300957 hasConcept C55493867 @default.
• W2142300957 hasConcept C61322309 @default.
• W2142300957 hasConcept C86803240 @default.
• W2142300957 hasConcept C89423630 @default.
• W2142300957 hasConcept C95444343 @default.
• W2142300957 hasConceptScore W2142300957C104317684 @default.
• W2142300957 hasConceptScore W2142300957C127561419 @default.
• W2142300957 hasConceptScore W2142300957C146587185 @default.
• W2142300957 hasConceptScore W2142300957C184235292 @default.
• W2142300957 hasConceptScore W2142300957C190283241 @default.
• W2142300957 hasConceptScore W2142300957C2777851122 @default.
• W2142300957 hasConceptScore W2142300957C2779166590 @default.
• W2142300957 hasConceptScore W2142300957C2781457462 @default.
• W2142300957 hasConceptScore W2142300957C41625074 @default.

• next