FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142321807> ?p ?o ?g. }

• W2142321807 endingPage "e002835" @default.
• W2142321807 startingPage "e002835" @default.
• W2142321807 abstract "<h3>Objectives</h3> To assess the impact of atopy and allergy on the risk of clinical malaria. <h3>Design</h3> A clinical and immunological allergy cross-sectional survey in a birth cohort of 175 children from 1 month to 14 years of age followed for up to 15 years in a longitudinal open cohort study of malaria in Senegal. Malaria incidence data were available for 143 of these children (aged 4 months to 14 years of age) for up to 15 years. Mixed-model regression analysis was used to determine the impact of allergy status on malaria incidence, adjusting for age, gender, sickle-cell trait and force of infection. <h3>Main outcome measures</h3> Asthma, allergic rhinoconjunctivitis and atopic dermatitis status, the number of clinical <i>Plasmodium falciparum</i> malaria episodes since birth and associated parasite density. <h3>Results</h3> 12% of the children were classified as asthmatic and 10% as having atopic dermatitis. These groups had respectively a twofold (OR 2.12 95%; CI 1.46 to 3.08; p=8×10⁻⁵) and threefold (OR 3.15; 1.56 to 6.33; p=1.3×10⁻³) increase in the risk of clinical <i>P falciparum</i> malaria once older than the age of peak incidence of clinical malaria (3–4 years of age). They also presented with higher <i>P falciparum</i> parasite densities (asthma: mean 105.3 parasites/μL±SE 41.0 vs 51.3±9.7; p=6.2×10⁻³. Atopic dermatitis: 135.4±70.7 vs 52.3±11.0; p=0.014). There was no effect of allergy on the number of non-malaria clinical presentations. Individuals with allergic rhinoconjunctivitis did not have an increased risk of clinical malaria nor any difference in parasite densities. <h3>Conclusions</h3> These results demonstrate that asthma and atopic dermatitis delay the development of clinical immunity to <i>P falciparum</i>. Despite the encouraging decrease in malaria incidence rates in Africa, a significant concern is the extent to which the increase in allergy will exacerbate the burden of malaria. Given the demonstrated antiparasitic effect of antihistamines, administration to atopic children will likely reduce the burden of clinical malaria in these children, increase the efficacy of first-line treatment antimalarials and alleviate the non-infectious consequences of atopy." @default.
• W2142321807 created "2016-06-24" @default.
• W2142321807 creator A5004065147 @default.
• W2142321807 creator A5007097198 @default.
• W2142321807 creator A5009626605 @default.
• W2142321807 creator A5031912931 @default.
• W2142321807 creator A5041547168 @default.
• W2142321807 creator A5041781725 @default.
• W2142321807 creator A5047703424 @default.
• W2142321807 creator A5050438558 @default.
• W2142321807 creator A5055055641 @default.
• W2142321807 creator A5066227901 @default.
• W2142321807 creator A5080293807 @default.
• W2142321807 creator A5081429602 @default.
• W2142321807 creator A5083823901 @default.
• W2142321807 date "2013-07-01" @default.
• W2142321807 modified "2023-10-18" @default.
• W2142321807 title "Asthma and atopic dermatitis are associated with increased risk of clinical<i>Plasmodium falciparum</i>malaria" @default.
• W2142321807 cites W1486120336 @default.
• W2142321807 cites W1500878045 @default.
• W2142321807 cites W1570073130 @default.
• W2142321807 cites W1964149115 @default.
• W2142321807 cites W1965734808 @default.
• W2142321807 cites W1974559013 @default.
• W2142321807 cites W1979416107 @default.
• W2142321807 cites W1980474385 @default.
• W2142321807 cites W1998091145 @default.
• W2142321807 cites W2002837591 @default.
• W2142321807 cites W2007374498 @default.
• W2142321807 cites W2008731781 @default.
• W2142321807 cites W2022146955 @default.
• W2142321807 cites W2022276896 @default.
• W2142321807 cites W2026828551 @default.
• W2142321807 cites W2040402905 @default.
• W2142321807 cites W2046064200 @default.
• W2142321807 cites W2054199384 @default.
• W2142321807 cites W2054250357 @default.
• W2142321807 cites W2067047380 @default.
• W2142321807 cites W2067557342 @default.
• W2142321807 cites W2068773216 @default.
• W2142321807 cites W2068824974 @default.
• W2142321807 cites W2069382029 @default.
• W2142321807 cites W2072346147 @default.
• W2142321807 cites W2077708386 @default.
• W2142321807 cites W2079427940 @default.
• W2142321807 cites W2080115051 @default.
• W2142321807 cites W2080172203 @default.
• W2142321807 cites W2093685379 @default.
• W2142321807 cites W2105306382 @default.
• W2142321807 cites W2110888991 @default.
• W2142321807 cites W2113035769 @default.
• W2142321807 cites W2113251371 @default.
• W2142321807 cites W2118016322 @default.
• W2142321807 cites W2120793327 @default.
• W2142321807 cites W2130215234 @default.
• W2142321807 cites W2132993315 @default.
• W2142321807 cites W2142010704 @default.
• W2142321807 cites W2144281476 @default.
• W2142321807 cites W2145783587 @default.
• W2142321807 cites W2147516417 @default.
• W2142321807 cites W2152264729 @default.
• W2142321807 cites W2155307784 @default.
• W2142321807 cites W2160655212 @default.
• W2142321807 cites W2172466148 @default.
• W2142321807 cites W2395097661 @default.
• W2142321807 cites W2407318164 @default.
• W2142321807 cites W2409288033 @default.
• W2142321807 doi "https://doi.org/10.1136/bmjopen-2013-002835" @default.
• W2142321807 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3731724" @default.
• W2142321807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23883878" @default.
• W2142321807 hasPublicationYear "2013" @default.
• W2142321807 type Work @default.
• W2142321807 sameAs 2142321807 @default.
• W2142321807 citedByCount "13" @default.
• W2142321807 countsByYear W21423218072015 @default.
• W2142321807 countsByYear W21423218072016 @default.
• W2142321807 countsByYear W21423218072017 @default.
• W2142321807 countsByYear W21423218072018 @default.
• W2142321807 countsByYear W21423218072019 @default.
• W2142321807 countsByYear W21423218072021 @default.
• W2142321807 crossrefType "journal-article" @default.
• W2142321807 hasAuthorship W2142321807A5004065147 @default.
• W2142321807 hasAuthorship W2142321807A5007097198 @default.
• W2142321807 hasAuthorship W2142321807A5009626605 @default.
• W2142321807 hasAuthorship W2142321807A5031912931 @default.
• W2142321807 hasAuthorship W2142321807A5041547168 @default.
• W2142321807 hasAuthorship W2142321807A5041781725 @default.
• W2142321807 hasAuthorship W2142321807A5047703424 @default.
• W2142321807 hasAuthorship W2142321807A5050438558 @default.
• W2142321807 hasAuthorship W2142321807A5055055641 @default.
• W2142321807 hasAuthorship W2142321807A5066227901 @default.
• W2142321807 hasAuthorship W2142321807A5080293807 @default.
• W2142321807 hasAuthorship W2142321807A5081429602 @default.
• W2142321807 hasAuthorship W2142321807A5083823901 @default.
• W2142321807 hasBestOaLocation W21423218071 @default.
• W2142321807 hasConcept C120665830 @default.
• W2142321807 hasConcept C121332964 @default.
• W2142321807 hasConcept C126322002 @default.

• next