Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142328532> ?p ?o ?g. }
- W2142328532 endingPage "264" @default.
- W2142328532 startingPage "252" @default.
- W2142328532 abstract "While type I interferons (IFNs) are universally acknowledged for their antiviral and immunostimulatory functions, there is increasing appreciation of the detrimental effects of inappropriate, excessive, or mistimed type I IFN responses in viral and bacterial infections. The underlying mechanisms by which type I IFNs promote susceptibility or severity include direct tissue damage by apoptosis induction or suppression of proliferation in tissue cells, immunopathology due to excessive inflammation, and cell death induced by TRAIL- and Fas-expressing immune cells, as well as immunosuppression through IL-10, IL-27, PD-L1, IL-1Ra, and other regulatory molecules that antagonize the induction or action of IL-1, IL-12, IL-17, IFN-γ, KC, and other effectors of the immune response. Bacterial superinfections following influenza infection are a prominent example of a situation where type I IFNs can misdirect the immune response. This review discusses current understanding of the parameters of signal strength, duration, timing, location, and cellular recipients that determine whether type I IFNs have beneficial or detrimental effects in infection." @default.
- W2142328532 created "2016-06-24" @default.
- W2142328532 creator A5017338682 @default.
- W2142328532 creator A5047530936 @default.
- W2142328532 creator A5085632483 @default.
- W2142328532 date "2015-04-01" @default.
- W2142328532 modified "2023-10-16" @default.
- W2142328532 title "Disease-Promoting Effects of Type I Interferons in Viral, Bacterial, and Coinfections" @default.
- W2142328532 cites W1507923077 @default.
- W2142328532 cites W1522207028 @default.
- W2142328532 cites W1570538430 @default.
- W2142328532 cites W1653080210 @default.
- W2142328532 cites W1967316517 @default.
- W2142328532 cites W1967928952 @default.
- W2142328532 cites W1969231504 @default.
- W2142328532 cites W1973691444 @default.
- W2142328532 cites W1973720948 @default.
- W2142328532 cites W1975228796 @default.
- W2142328532 cites W1977562072 @default.
- W2142328532 cites W1979386505 @default.
- W2142328532 cites W1982280354 @default.
- W2142328532 cites W1983483525 @default.
- W2142328532 cites W1983714443 @default.
- W2142328532 cites W1984866950 @default.
- W2142328532 cites W1986696487 @default.
- W2142328532 cites W1987009823 @default.
- W2142328532 cites W1989618496 @default.
- W2142328532 cites W1994292458 @default.
- W2142328532 cites W1996311210 @default.
- W2142328532 cites W1997384271 @default.
- W2142328532 cites W2000177767 @default.
- W2142328532 cites W2003831905 @default.
- W2142328532 cites W2004829503 @default.
- W2142328532 cites W2006258452 @default.
- W2142328532 cites W2006328907 @default.
- W2142328532 cites W2006425559 @default.
- W2142328532 cites W2009522156 @default.
- W2142328532 cites W2011516984 @default.
- W2142328532 cites W2013202475 @default.
- W2142328532 cites W2019292153 @default.
- W2142328532 cites W2020173029 @default.
- W2142328532 cites W2022684844 @default.
- W2142328532 cites W2023044372 @default.
- W2142328532 cites W2023478821 @default.
- W2142328532 cites W2024556668 @default.
- W2142328532 cites W2027844128 @default.
- W2142328532 cites W2028497025 @default.
- W2142328532 cites W2031200605 @default.
- W2142328532 cites W2031235649 @default.
- W2142328532 cites W2031472841 @default.
- W2142328532 cites W2031799273 @default.
- W2142328532 cites W2031913105 @default.
- W2142328532 cites W2032969319 @default.
- W2142328532 cites W2034966611 @default.
- W2142328532 cites W2035509260 @default.
- W2142328532 cites W2037457284 @default.
- W2142328532 cites W2041111263 @default.
- W2142328532 cites W2043015250 @default.
- W2142328532 cites W2043304383 @default.
- W2142328532 cites W2047742947 @default.
- W2142328532 cites W2047948762 @default.
- W2142328532 cites W2049868800 @default.
- W2142328532 cites W2051173965 @default.
- W2142328532 cites W2052374402 @default.
- W2142328532 cites W2053796616 @default.
- W2142328532 cites W2054178434 @default.
- W2142328532 cites W2058235794 @default.
- W2142328532 cites W2060926084 @default.
- W2142328532 cites W2064823659 @default.
- W2142328532 cites W2065217848 @default.
- W2142328532 cites W2069439138 @default.
- W2142328532 cites W2070570719 @default.
- W2142328532 cites W2071296698 @default.
- W2142328532 cites W2072158757 @default.
- W2142328532 cites W2073234751 @default.
- W2142328532 cites W2073526502 @default.
- W2142328532 cites W2075800785 @default.
- W2142328532 cites W2076298858 @default.
- W2142328532 cites W2078993960 @default.
- W2142328532 cites W2082146590 @default.
- W2142328532 cites W2083162205 @default.
- W2142328532 cites W2084152099 @default.
- W2142328532 cites W2084409051 @default.
- W2142328532 cites W2084848633 @default.
- W2142328532 cites W2085237060 @default.
- W2142328532 cites W2088534886 @default.
- W2142328532 cites W2096542836 @default.
- W2142328532 cites W2099781711 @default.
- W2142328532 cites W2102184637 @default.
- W2142328532 cites W2103069849 @default.
- W2142328532 cites W2104586170 @default.
- W2142328532 cites W2105053798 @default.
- W2142328532 cites W2105169654 @default.
- W2142328532 cites W2105431972 @default.
- W2142328532 cites W2105517511 @default.
- W2142328532 cites W2105764241 @default.
- W2142328532 cites W2106377620 @default.
- W2142328532 cites W2106701493 @default.