Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142331967> ?p ?o ?g. }
- W2142331967 endingPage "915" @default.
- W2142331967 startingPage "902" @default.
- W2142331967 abstract "Abstract Despite significant advances in biology and medicine, the incidence and mortality due to breast cancer worldwide is still unacceptably high. Thus, there is an urgent need to discover new molecular targets. In this article, we show evidence for a novel target in human breast cancer, the tetraspan protein epithelial membrane protein-2 (EMP2). Using tissue tumor arrays, protein expression of EMP2 was measured and found to be minimal in normal mammary tissue, but it was upregulated in 63% of invasive breast cancer tumors and in 73% of triple-negative tumors tested. To test the hypothesis that EMP2 may be a suitable target for therapy, we constructed a fully human immunoglobulin G1 (IgG1) antibody specific for a conserved domain of human and murine EMP2. Treatment of breast cancer cells with the anti-EMP2 IgG1 significantly inhibited EMP2-mediated signaling, blocked FAK/Src signaling, inhibited invasion, and promoted apoptosis in vitro. In both human xenograft and syngeneic metastatic tumor monotherapy models, anti-EMP2 IgG1 retarded tumor growth without detectable systemic toxicity. This antitumor effect was, in part, attributable to a potent antibody-dependent cell-mediated cytotoxicity response as well as direct cytotoxicity induced by the monoclonal antibody. Together, these results identify EMP2 as a novel therapeutic target for invasive breast cancer. Mol Cancer Ther; 13(4); 902–15. ©2014 AACR." @default.
- W2142331967 created "2016-06-24" @default.
- W2142331967 creator A5004675513 @default.
- W2142331967 creator A5006079178 @default.
- W2142331967 creator A5021174842 @default.
- W2142331967 creator A5024027520 @default.
- W2142331967 creator A5026242706 @default.
- W2142331967 creator A5028534631 @default.
- W2142331967 creator A5031406053 @default.
- W2142331967 creator A5044535902 @default.
- W2142331967 creator A5049546733 @default.
- W2142331967 creator A5053542215 @default.
- W2142331967 creator A5081790862 @default.
- W2142331967 creator A5084071436 @default.
- W2142331967 creator A5084486790 @default.
- W2142331967 creator A5090080528 @default.
- W2142331967 creator A5090286281 @default.
- W2142331967 date "2014-04-01" @default.
- W2142331967 modified "2023-10-11" @default.
- W2142331967 title "Rationale and Preclinical Efficacy of a Novel Anti-EMP2 Antibody for the Treatment of Invasive Breast Cancer" @default.
- W2142331967 cites W1603858947 @default.
- W2142331967 cites W1964081894 @default.
- W2142331967 cites W1967194148 @default.
- W2142331967 cites W1967659496 @default.
- W2142331967 cites W1967961147 @default.
- W2142331967 cites W1968428572 @default.
- W2142331967 cites W1968464607 @default.
- W2142331967 cites W1981989535 @default.
- W2142331967 cites W1985856150 @default.
- W2142331967 cites W1987695688 @default.
- W2142331967 cites W1995022608 @default.
- W2142331967 cites W1995036570 @default.
- W2142331967 cites W1996820981 @default.
- W2142331967 cites W1997488451 @default.
- W2142331967 cites W2004280628 @default.
- W2142331967 cites W2007265656 @default.
- W2142331967 cites W2009218955 @default.
- W2142331967 cites W2023720844 @default.
- W2142331967 cites W2023826235 @default.
- W2142331967 cites W2024389915 @default.
- W2142331967 cites W2035545617 @default.
- W2142331967 cites W2036008499 @default.
- W2142331967 cites W2037763398 @default.
- W2142331967 cites W2042108891 @default.
- W2142331967 cites W2044678751 @default.
- W2142331967 cites W2052874737 @default.
- W2142331967 cites W2053141710 @default.
- W2142331967 cites W2061452886 @default.
- W2142331967 cites W2066122607 @default.
- W2142331967 cites W2068326740 @default.
- W2142331967 cites W2083865210 @default.
- W2142331967 cites W2096027508 @default.
- W2142331967 cites W2114050793 @default.
- W2142331967 cites W2117346624 @default.
- W2142331967 cites W2122312650 @default.
- W2142331967 cites W2122931235 @default.
- W2142331967 cites W2128985829 @default.
- W2142331967 cites W2131480102 @default.
- W2142331967 cites W2135967835 @default.
- W2142331967 cites W2136029031 @default.
- W2142331967 cites W2137745988 @default.
- W2142331967 cites W2140272347 @default.
- W2142331967 cites W2141770615 @default.
- W2142331967 cites W2148006813 @default.
- W2142331967 cites W2149189866 @default.
- W2142331967 cites W2155252583 @default.
- W2142331967 cites W2162506508 @default.
- W2142331967 cites W2165948908 @default.
- W2142331967 doi "https://doi.org/10.1158/1535-7163.mct-13-0199" @default.
- W2142331967 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4034757" @default.
- W2142331967 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24448822" @default.
- W2142331967 hasPublicationYear "2014" @default.
- W2142331967 type Work @default.
- W2142331967 sameAs 2142331967 @default.
- W2142331967 citedByCount "37" @default.
- W2142331967 countsByYear W21423319672014 @default.
- W2142331967 countsByYear W21423319672015 @default.
- W2142331967 countsByYear W21423319672017 @default.
- W2142331967 countsByYear W21423319672018 @default.
- W2142331967 countsByYear W21423319672019 @default.
- W2142331967 countsByYear W21423319672020 @default.
- W2142331967 countsByYear W21423319672021 @default.
- W2142331967 countsByYear W21423319672022 @default.
- W2142331967 countsByYear W21423319672023 @default.
- W2142331967 crossrefType "journal-article" @default.
- W2142331967 hasAuthorship W2142331967A5004675513 @default.
- W2142331967 hasAuthorship W2142331967A5006079178 @default.
- W2142331967 hasAuthorship W2142331967A5021174842 @default.
- W2142331967 hasAuthorship W2142331967A5024027520 @default.
- W2142331967 hasAuthorship W2142331967A5026242706 @default.
- W2142331967 hasAuthorship W2142331967A5028534631 @default.
- W2142331967 hasAuthorship W2142331967A5031406053 @default.
- W2142331967 hasAuthorship W2142331967A5044535902 @default.
- W2142331967 hasAuthorship W2142331967A5049546733 @default.
- W2142331967 hasAuthorship W2142331967A5053542215 @default.
- W2142331967 hasAuthorship W2142331967A5081790862 @default.
- W2142331967 hasAuthorship W2142331967A5084071436 @default.
- W2142331967 hasAuthorship W2142331967A5084486790 @default.