Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142356297> ?p ?o ?g. }
- W2142356297 endingPage "307" @default.
- W2142356297 startingPage "288" @default.
- W2142356297 abstract "Tuberculosis (TB) lesions are extremely complex and dynamic. Here, we review the multiple types and fates of pulmonary lesions that form following infection by Mycobacterium tuberculosis and the impact of this spatial and temporal heterogeneity on the bacteria they harbor. The diverse immunopathology of granulomas and cavities generates a plethora of microenvironments to which M. tuberculosis bacilli must adapt. This in turn affects the replication, metabolism, and relative density of bacterial subpopulations, and consequently their respective susceptibility to chemotherapy. We outline recent developments that support a paradigm shift in our understanding of lesion progression. The simple model according to which lesions within a single individual react similarly to the systemic immune response no longer prevails. Host-pathogen interactions within lesions are a dynamic process, driven by subtle and local differences in signaling pathways, resulting in diverging trajectories of lesions within a single host. The spectrum of TB lesions is a continuum with a large overlap in the lesion types found in latently infected and active TB patients. We hope this overview will guide TB researchers in the design, choice of read-outs, and interpretation of future studies in the search for predictive biomarkers and novel therapies." @default.
- W2142356297 created "2016-06-24" @default.
- W2142356297 creator A5007366821 @default.
- W2142356297 creator A5018322506 @default.
- W2142356297 creator A5048759299 @default.
- W2142356297 date "2015-02-20" @default.
- W2142356297 modified "2023-10-12" @default.
- W2142356297 title "Heterogeneity in tuberculosis pathology, microenvironments and therapeutic responses" @default.
- W2142356297 cites W113437334 @default.
- W2142356297 cites W117549336 @default.
- W2142356297 cites W1498486243 @default.
- W2142356297 cites W1691983633 @default.
- W2142356297 cites W1864461701 @default.
- W2142356297 cites W1898771364 @default.
- W2142356297 cites W1912458322 @default.
- W2142356297 cites W1964291085 @default.
- W2142356297 cites W1964322183 @default.
- W2142356297 cites W1964889189 @default.
- W2142356297 cites W1968913216 @default.
- W2142356297 cites W1969055840 @default.
- W2142356297 cites W1969623044 @default.
- W2142356297 cites W1970610212 @default.
- W2142356297 cites W1972005767 @default.
- W2142356297 cites W1972851920 @default.
- W2142356297 cites W1973720948 @default.
- W2142356297 cites W1976566701 @default.
- W2142356297 cites W1979690999 @default.
- W2142356297 cites W1985905472 @default.
- W2142356297 cites W1986514504 @default.
- W2142356297 cites W1986815067 @default.
- W2142356297 cites W1987818432 @default.
- W2142356297 cites W1988243313 @default.
- W2142356297 cites W1988576353 @default.
- W2142356297 cites W1991233072 @default.
- W2142356297 cites W1992027784 @default.
- W2142356297 cites W1992232557 @default.
- W2142356297 cites W1994971990 @default.
- W2142356297 cites W1996074726 @default.
- W2142356297 cites W1998211794 @default.
- W2142356297 cites W2000241568 @default.
- W2142356297 cites W2002397610 @default.
- W2142356297 cites W2004753123 @default.
- W2142356297 cites W2006789966 @default.
- W2142356297 cites W2007097682 @default.
- W2142356297 cites W2007186942 @default.
- W2142356297 cites W2008952784 @default.
- W2142356297 cites W2011386209 @default.
- W2142356297 cites W2012739322 @default.
- W2142356297 cites W2013972132 @default.
- W2142356297 cites W2014262351 @default.
- W2142356297 cites W2015648468 @default.
- W2142356297 cites W2018292120 @default.
- W2142356297 cites W2024868455 @default.
- W2142356297 cites W2025395369 @default.
- W2142356297 cites W2031450179 @default.
- W2142356297 cites W2031948094 @default.
- W2142356297 cites W2032227357 @default.
- W2142356297 cites W2033541022 @default.
- W2142356297 cites W2033840976 @default.
- W2142356297 cites W2040544951 @default.
- W2142356297 cites W2040694642 @default.
- W2142356297 cites W2044101419 @default.
- W2142356297 cites W2047330514 @default.
- W2142356297 cites W2051792510 @default.
- W2142356297 cites W2053867514 @default.
- W2142356297 cites W2056521763 @default.
- W2142356297 cites W2059120529 @default.
- W2142356297 cites W2064458258 @default.
- W2142356297 cites W2065049812 @default.
- W2142356297 cites W2065100101 @default.
- W2142356297 cites W2066388620 @default.
- W2142356297 cites W2069179741 @default.
- W2142356297 cites W2073054137 @default.
- W2142356297 cites W2074759507 @default.
- W2142356297 cites W2074862238 @default.
- W2142356297 cites W2074992777 @default.
- W2142356297 cites W2075795553 @default.
- W2142356297 cites W2076872537 @default.
- W2142356297 cites W2078663039 @default.
- W2142356297 cites W2081024768 @default.
- W2142356297 cites W2081325862 @default.
- W2142356297 cites W2085004267 @default.
- W2142356297 cites W2086294902 @default.
- W2142356297 cites W2090007622 @default.
- W2142356297 cites W2092448486 @default.
- W2142356297 cites W2097659626 @default.
- W2142356297 cites W2098485516 @default.
- W2142356297 cites W2099183065 @default.
- W2142356297 cites W2099216140 @default.
- W2142356297 cites W2101963972 @default.
- W2142356297 cites W2105228567 @default.
- W2142356297 cites W2107270161 @default.
- W2142356297 cites W2109531704 @default.
- W2142356297 cites W2109543073 @default.
- W2142356297 cites W2110551379 @default.
- W2142356297 cites W2112021008 @default.
- W2142356297 cites W2112626622 @default.
- W2142356297 cites W2113853582 @default.