FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142366629> ?p ?o ?g. }

• W2142366629 endingPage "829" @default.
• W2142366629 startingPage "821" @default.
• W2142366629 abstract "A core promoter element called an initiator (Inr) overlaps the transcription start site of numerous mammalian protein-coding genes. In promoters that lack a TATA box, the Inr is functionally analogous to TATA, in that it is capable of directing basal transcription by RNA polymerase II and of determining the precise site of transcription initiation. In promoters that contain a TATA box, the Inr can greatly enhance promoter strength. Mammalian Inr consensus sequences have been defined through functional studies and sequence comparisons of the start site regions of protein-coding genes. Here, we show that, in a DNase I footprinting assay with synthetic promoters, the purified TATA-binding protein complex TFIID specifically contacted the Inr. The TFIID-Inr interaction relies on the precise nucleotides needed for Inr function. Detection of the interaction was dependent either on a TATA box or on Sp1 bound to upstream sites. Furthermore, recombinant TFIIB appeared to influence the TFIID-Inr interaction, whereas TFIIA stabilized the TFIID-TATA interaction. These results demonstrate that distinct components of TFIID interact with the TATA boxes and Inr elements of core promoters for RNA polymerase II." @default.
• W2142366629 created "2016-06-24" @default.
• W2142366629 creator A5055489898 @default.
• W2142366629 creator A5066283050 @default.
• W2142366629 date "1994-04-01" @default.
• W2142366629 modified "2023-10-14" @default.
• W2142366629 title "Direct recognition of initiator elements by a component of the transcription factor IID complex." @default.
• W2142366629 cites W1230664046 @default.
• W2142366629 cites W1555065911 @default.
• W2142366629 cites W1759777836 @default.
• W2142366629 cites W1932076246 @default.
• W2142366629 cites W1980483123 @default.
• W2142366629 cites W1986473194 @default.
• W2142366629 cites W1996251138 @default.
• W2142366629 cites W1999156595 @default.
• W2142366629 cites W1999966058 @default.
• W2142366629 cites W2010026543 @default.
• W2142366629 cites W2013980278 @default.
• W2142366629 cites W2040193953 @default.
• W2142366629 cites W2041230251 @default.
• W2142366629 cites W2042425655 @default.
• W2142366629 cites W2042688292 @default.
• W2142366629 cites W2063469451 @default.
• W2142366629 cites W2074351361 @default.
• W2142366629 cites W2074701310 @default.
• W2142366629 cites W2088577765 @default.
• W2142366629 cites W2089537847 @default.
• W2142366629 cites W2092439254 @default.
• W2142366629 cites W2107624922 @default.
• W2142366629 cites W2136690570 @default.
• W2142366629 cites W2333702151 @default.
• W2142366629 cites W4233799830 @default.
• W2142366629 cites W4246505086 @default.
• W2142366629 doi "https://doi.org/10.1101/gad.8.7.821" @default.
• W2142366629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7926770" @default.
• W2142366629 hasPublicationYear "1994" @default.
• W2142366629 type Work @default.
• W2142366629 sameAs 2142366629 @default.
• W2142366629 citedByCount "245" @default.
• W2142366629 countsByYear W21423666292012 @default.
• W2142366629 countsByYear W21423666292013 @default.
• W2142366629 countsByYear W21423666292014 @default.
• W2142366629 countsByYear W21423666292015 @default.
• W2142366629 countsByYear W21423666292016 @default.
• W2142366629 countsByYear W21423666292017 @default.
• W2142366629 countsByYear W21423666292018 @default.
• W2142366629 countsByYear W21423666292020 @default.
• W2142366629 countsByYear W21423666292021 @default.
• W2142366629 countsByYear W21423666292022 @default.
• W2142366629 countsByYear W21423666292023 @default.
• W2142366629 crossrefType "journal-article" @default.
• W2142366629 hasAuthorship W2142366629A5055489898 @default.
• W2142366629 hasAuthorship W2142366629A5066283050 @default.
• W2142366629 hasBestOaLocation W21423666291 @default.
• W2142366629 hasConcept C101762097 @default.
• W2142366629 hasConcept C102622118 @default.
• W2142366629 hasConcept C104317684 @default.
• W2142366629 hasConcept C105208137 @default.
• W2142366629 hasConcept C144825837 @default.
• W2142366629 hasConcept C146027311 @default.
• W2142366629 hasConcept C150194340 @default.
• W2142366629 hasConcept C153911025 @default.
• W2142366629 hasConcept C172768829 @default.
• W2142366629 hasConcept C188740287 @default.
• W2142366629 hasConcept C2909959438 @default.
• W2142366629 hasConcept C44498088 @default.
• W2142366629 hasConcept C54355233 @default.
• W2142366629 hasConcept C64350747 @default.
• W2142366629 hasConcept C65888428 @default.
• W2142366629 hasConcept C86803240 @default.
• W2142366629 hasConceptScore W2142366629C101762097 @default.
• W2142366629 hasConceptScore W2142366629C102622118 @default.
• W2142366629 hasConceptScore W2142366629C104317684 @default.
• W2142366629 hasConceptScore W2142366629C105208137 @default.
• W2142366629 hasConceptScore W2142366629C144825837 @default.
• W2142366629 hasConceptScore W2142366629C146027311 @default.
• W2142366629 hasConceptScore W2142366629C150194340 @default.
• W2142366629 hasConceptScore W2142366629C153911025 @default.
• W2142366629 hasConceptScore W2142366629C172768829 @default.
• W2142366629 hasConceptScore W2142366629C188740287 @default.
• W2142366629 hasConceptScore W2142366629C2909959438 @default.
• W2142366629 hasConceptScore W2142366629C44498088 @default.
• W2142366629 hasConceptScore W2142366629C54355233 @default.
• W2142366629 hasConceptScore W2142366629C64350747 @default.
• W2142366629 hasConceptScore W2142366629C65888428 @default.
• W2142366629 hasConceptScore W2142366629C86803240 @default.
• W2142366629 hasIssue "7" @default.
• W2142366629 hasLocation W21423666291 @default.
• W2142366629 hasLocation W21423666292 @default.
• W2142366629 hasOpenAccess W2142366629 @default.
• W2142366629 hasPrimaryLocation W21423666291 @default.
• W2142366629 hasRelatedWork W1264979566 @default.
• W2142366629 hasRelatedWork W2027073894 @default.
• W2142366629 hasRelatedWork W2036603335 @default.
• W2142366629 hasRelatedWork W2041230251 @default.
• W2142366629 hasRelatedWork W2101341060 @default.
• W2142366629 hasRelatedWork W2142366629 @default.
• W2142366629 hasRelatedWork W2169867753 @default.

• next