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- W2142393381 abstract "Vasoactive intestinal polypeptide (VIP) is an immunomodulatory neuropeptide widely distributed in neural pathways that regulate micturition. VIP is also an endogenous anti-inflammatory agent that has been suggested for the development of therapies for inflammatory disorders. In the present study, we examined urinary bladder function and hindpaw and pelvic sensitivity in VIP(-/-) and littermate wildtype (WT) controls. We demonstrated increased bladder mass and fewer but larger urine spots on filter paper in VIP(-/-) mice. Using cystometry in conscious, unrestrained mice, VIP(-/-) mice exhibited increased void volumes and shorter intercontraction intervals with continuous intravesical infusion of saline. No differences in transepithelial resistance or water permeability were demonstrated between VIP(-/-) and WT mice; however, an increase in urea permeability was demonstrated in VIP(-/-) mice. With the induction of bladder inflammation by acute administration of cyclophosphamide, an exaggerated or prolonged bladder hyperreflexia and hindpaw and pelvic sensitivity were demonstrated in VIP(-/-) mice. The changes in bladder hyperreflexia and somatic sensitivity in VIP(-/-) mice may reflect increased expression of neurotrophins and/or proinflammatory cytokines in the urinary bladder. Thus, these changes may further regulate the neural control of micturition." @default.
- W2142393381 created "2016-06-24" @default.
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- W2142393381 date "2008-06-17" @default.
- W2142393381 modified "2023-10-14" @default.
- W2142393381 title "Urinary Bladder Function and Somatic Sensitivity in Vasoactive Intestinal Polypeptide (VIP)−/− Mice" @default.
- W2142393381 cites W1256336268 @default.
- W2142393381 cites W1496633211 @default.
- W2142393381 cites W1561891673 @default.
- W2142393381 cites W1586892645 @default.
- W2142393381 cites W1612226764 @default.
- W2142393381 cites W1759868377 @default.
- W2142393381 cites W1802868417 @default.
- W2142393381 cites W1965639668 @default.
- W2142393381 cites W1965847743 @default.
- W2142393381 cites W1966300307 @default.
- W2142393381 cites W1966568735 @default.
- W2142393381 cites W1967259593 @default.
- W2142393381 cites W1971213778 @default.
- W2142393381 cites W1971566600 @default.
- W2142393381 cites W1975622350 @default.
- W2142393381 cites W1978378955 @default.
- W2142393381 cites W1979351468 @default.
- W2142393381 cites W1979541794 @default.
- W2142393381 cites W1980358253 @default.
- W2142393381 cites W1981503464 @default.
- W2142393381 cites W1987075214 @default.
- W2142393381 cites W1989713749 @default.
- W2142393381 cites W1991799302 @default.
- W2142393381 cites W1995110348 @default.
- W2142393381 cites W1999561963 @default.
- W2142393381 cites W2000601984 @default.
- W2142393381 cites W2002748973 @default.
- W2142393381 cites W2007372074 @default.
- W2142393381 cites W2007827530 @default.
- W2142393381 cites W2007852083 @default.
- W2142393381 cites W2011174713 @default.
- W2142393381 cites W2013488690 @default.
- W2142393381 cites W2014267662 @default.
- W2142393381 cites W2017042426 @default.
- W2142393381 cites W2021981193 @default.
- W2142393381 cites W2023184460 @default.
- W2142393381 cites W2028678089 @default.
- W2142393381 cites W2029799937 @default.
- W2142393381 cites W2032798396 @default.
- W2142393381 cites W2033847316 @default.
- W2142393381 cites W2036445582 @default.
- W2142393381 cites W2041043051 @default.
- W2142393381 cites W2042125279 @default.
- W2142393381 cites W2044154060 @default.
- W2142393381 cites W2045749627 @default.
- W2142393381 cites W2053496584 @default.
- W2142393381 cites W2055119809 @default.
- W2142393381 cites W2059034808 @default.
- W2142393381 cites W2059181932 @default.
- W2142393381 cites W2060621129 @default.
- W2142393381 cites W2060948025 @default.
- W2142393381 cites W2061549656 @default.
- W2142393381 cites W2063308564 @default.
- W2142393381 cites W2068146214 @default.
- W2142393381 cites W2071657406 @default.
- W2142393381 cites W2071973495 @default.
- W2142393381 cites W2077836261 @default.
- W2142393381 cites W2079964185 @default.
- W2142393381 cites W2080067399 @default.
- W2142393381 cites W2080341103 @default.
- W2142393381 cites W2081992721 @default.
- W2142393381 cites W2083537312 @default.
- W2142393381 cites W2093836826 @default.
- W2142393381 cites W2098509280 @default.
- W2142393381 cites W2102921818 @default.
- W2142393381 cites W2109358424 @default.
- W2142393381 cites W2112439786 @default.
- W2142393381 cites W2115064235 @default.
- W2142393381 cites W2115412021 @default.
- W2142393381 cites W2116764810 @default.
- W2142393381 cites W2129971651 @default.
- W2142393381 cites W2130358771 @default.
- W2142393381 cites W2130555616 @default.
- W2142393381 cites W2131166849 @default.
- W2142393381 cites W2132926305 @default.
- W2142393381 cites W2133022796 @default.
- W2142393381 cites W2134353590 @default.
- W2142393381 cites W2136666704 @default.
- W2142393381 cites W2137384640 @default.
- W2142393381 cites W2143561995 @default.
- W2142393381 cites W2145096738 @default.
- W2142393381 cites W2147467121 @default.
- W2142393381 cites W2158064024 @default.