FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142401422> ?p ?o ?g. }

• W2142401422 endingPage "46" @default.
• W2142401422 startingPage "337" @default.
• W2142401422 abstract "A comparative study was performed on the venoms of adult specimens of the neotropical rattlesnake, Crotalus durissus, from Guatemala, Costa Rica, Venezuela and Brazil, together with the venom of newborn specimens of C. d. durissus from Costa Rica. Venoms from Brazil (C. d. terrificus) and from newborn specimens of C. d. durissus presented an electrophoretic pattern characterized by the predominance of bands with molecular mass of 36 and 15 kDa, whereas those of adult specimens of C. d. durissus from Guatemala and Costa Rica, and C. d. cumanensis from Venezuela, showed a conspicuous band of 62 kDa, and additional bands of 36, 29 and 15 kDa. Moreover, venoms from C. d. terrificus and C. d. cumanensis showed a prominent band of < 10 kDa that probably corresponds to crotamine, since a 'crotamine-like' activity was detected in these venoms upon intraperitoneal injection in mice. Venoms of C. d. terrificus, C. d cumanensis and newborn C. d. durissus induced higher lethal and myotoxic effects than those of adult C. d. durissus. In contrast, adult C. d. durissus and C. d. cumanensis venoms induced hemorrhage, whereas venoms of C. d. terrificus and newborn C. d. durissus lacked this effect. All venoms showed coagulant effect in plasma, the highest activity being observed in the venom of newborn C. d. durissus. An anti-crotalic antivenom produced by Instituto Butantan (Brazil), using C. d. terrificus venom as antigen, was effective in the neutralization of lethal, myotoxic and coagulant effects of all venoms studied, being ineffective in the neutralization of hemorrhagic activity of the venoms of C. d. cumanensis and C. d. durissus. On the other hand, a polyvalent antivenom produced by Instituto Clodomiro Picado (Costa Rica), using the venoms of C. d. durissus. Bothrops asper and Lachesis stenophrys as antigens, was able to neutralize lethal, myotoxic, coagulant and hemorrhagic effects of C. d. durissus venom, but was ineffective in the neutralization of lethality and myotoxicity of C. d. terrificus, C. d. cumanensis and newborn C. d. durissus venom. The high toxicity of South American and newborn C. d. durissus venoms is related to the presence of high concentrations of the neurotoxic phospholipase A2 complex 'crotoxin'. Accordingly, antivenom from Instituto Butantan has a much higher titer of anti-crotoxin antibodies than antivenom from Instituto Clodomiro Picado. Crotalus durissus represents an example of intraspecies variation in venom composition and pharmacology that has relevant pathophysiologic and therapeutic implications." @default.
• W2142401422 created "2016-06-24" @default.
• W2142401422 creator A5005009944 @default.
• W2142401422 creator A5025490286 @default.
• W2142401422 creator A5026522587 @default.
• W2142401422 creator A5034059629 @default.
• W2142401422 creator A5034667331 @default.
• W2142401422 creator A5046319272 @default.
• W2142401422 creator A5063403496 @default.
• W2142401422 creator A5074828371 @default.
• W2142401422 creator A5091394100 @default.
• W2142401422 date "2002-03-01" @default.
• W2142401422 modified "2023-10-15" @default.
• W2142401422 title "Geographic and ontogenic variability in the venom of the neotropical rattlesnake Crotalus durissus: pathophysiological and therapeutic implications." @default.
• W2142401422 cites W1458979797 @default.
• W2142401422 cites W1642031822 @default.
• W2142401422 cites W1983820236 @default.
• W2142401422 cites W1985751934 @default.
• W2142401422 cites W1985923809 @default.
• W2142401422 cites W1999351781 @default.
• W2142401422 cites W1999774962 @default.
• W2142401422 cites W2008964357 @default.
• W2142401422 cites W2011260915 @default.
• W2142401422 cites W2013238756 @default.
• W2142401422 cites W2019182834 @default.
• W2142401422 cites W2021833730 @default.
• W2142401422 cites W2030046736 @default.
• W2142401422 cites W2032588094 @default.
• W2142401422 cites W2049980314 @default.
• W2142401422 cites W2055558683 @default.
• W2142401422 cites W2070304599 @default.
• W2142401422 cites W2080754742 @default.
• W2142401422 cites W2100837269 @default.
• W2142401422 cites W2110659553 @default.
• W2142401422 cites W2150023957 @default.
• W2142401422 cites W2155548832 @default.
• W2142401422 cites W2158904285 @default.
• W2142401422 cites W2275021923 @default.
• W2142401422 cites W2313430757 @default.
• W2142401422 cites W247394854 @default.
• W2142401422 cites W2487669150 @default.
• W2142401422 cites W2896105429 @default.
• W2142401422 cites W2341428135 @default.
• W2142401422 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12298262" @default.
• W2142401422 hasPublicationYear "2002" @default.
• W2142401422 type Work @default.
• W2142401422 sameAs 2142401422 @default.
• W2142401422 citedByCount "39" @default.
• W2142401422 countsByYear W21424014222012 @default.
• W2142401422 countsByYear W21424014222013 @default.
• W2142401422 countsByYear W21424014222016 @default.
• W2142401422 countsByYear W21424014222017 @default.
• W2142401422 countsByYear W21424014222018 @default.
• W2142401422 countsByYear W21424014222019 @default.
• W2142401422 countsByYear W21424014222020 @default.
• W2142401422 countsByYear W21424014222022 @default.
• W2142401422 countsByYear W21424014222023 @default.
• W2142401422 crossrefType "journal-article" @default.
• W2142401422 hasAuthorship W2142401422A5005009944 @default.
• W2142401422 hasAuthorship W2142401422A5025490286 @default.
• W2142401422 hasAuthorship W2142401422A5026522587 @default.
• W2142401422 hasAuthorship W2142401422A5034059629 @default.
• W2142401422 hasAuthorship W2142401422A5034667331 @default.
• W2142401422 hasAuthorship W2142401422A5046319272 @default.
• W2142401422 hasAuthorship W2142401422A5063403496 @default.
• W2142401422 hasAuthorship W2142401422A5074828371 @default.
• W2142401422 hasAuthorship W2142401422A5091394100 @default.
• W2142401422 hasConcept C153911025 @default.
• W2142401422 hasConcept C18903297 @default.
• W2142401422 hasConcept C2779448229 @default.
• W2142401422 hasConcept C2780331750 @default.
• W2142401422 hasConcept C86803240 @default.
• W2142401422 hasConcept C98274493 @default.
• W2142401422 hasConceptScore W2142401422C153911025 @default.
• W2142401422 hasConceptScore W2142401422C18903297 @default.
• W2142401422 hasConceptScore W2142401422C2779448229 @default.
• W2142401422 hasConceptScore W2142401422C2780331750 @default.
• W2142401422 hasConceptScore W2142401422C86803240 @default.
• W2142401422 hasConceptScore W2142401422C98274493 @default.
• W2142401422 hasIssue "1" @default.
• W2142401422 hasLocation W21424014221 @default.
• W2142401422 hasOpenAccess W2142401422 @default.
• W2142401422 hasPrimaryLocation W21424014221 @default.
• W2142401422 hasRelatedWork W1901040329 @default.
• W2142401422 hasRelatedWork W1984831804 @default.
• W2142401422 hasRelatedWork W1990161322 @default.
• W2142401422 hasRelatedWork W2024811311 @default.
• W2142401422 hasRelatedWork W2030357658 @default.
• W2142401422 hasRelatedWork W2075873312 @default.
• W2142401422 hasRelatedWork W2093768782 @default.
• W2142401422 hasRelatedWork W2113606578 @default.
• W2142401422 hasRelatedWork W2736188283 @default.
• W2142401422 hasRelatedWork W3199780915 @default.
• W2142401422 hasVolume "50" @default.
• W2142401422 isParatext "false" @default.
• W2142401422 isRetracted "false" @default.
• W2142401422 magId "2142401422" @default.
• W2142401422 workType "article" @default.