FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142469321> ?p ?o ?g. }

• W2142469321 endingPage "993" @default.
• W2142469321 startingPage "987" @default.
• W2142469321 abstract "Apolipoprotein D (apoD) expression was studied in nonneoplastic peripheral nerve, neurofibromas (NFs), and malignant peripheral nerve sheath tumors (MPNSTs) by quantitative polymerase chain reaction, in situ hybridization, and immunohistochemistry. Multiplex quantitative polymerase chain reaction for messenger RNA was performed on a series of formalin-fixed and paraffin-embedded specimens that included 9 MPNSTs, 12 NFs, and 4 normal peripheral nerves. The average apoD expression was 108-fold decreased (ΔCt = −7.3) in the MPNSTs compared with the NFs (P < .05). ApoD expression levels were 3.0-fold elevated (ΔCt = 1.7) in the NFs compared with nonneoplastic peripheral nerve (P < .05). In situ hybridization for apoD RNA was performed on a separate series of 10 cases in which each microscopic section included both MPNST and the NF from which it arose. These studies confirmed elevated apoD expression in NFs compared with MPNSTs and demonstrated that this expression was variable among individual cells within the NFs. Differential expression by immunohistochemistry could only be demonstrated in selected areas, most likely because apoD protein is a small molecule that is secreted out of the cell into the extracellular space and plasma. ApoD expression initially increases a small amount with the formation of NFs from nonneoplastic peripheral nerve and subsequently decreases markedly as NFs transform into MPNSTs. This expression pattern may serve as a marker for cell cycle inhibition during peripheral nerve tumorigenesis." @default.
• W2142469321 created "2016-06-24" @default.
• W2142469321 creator A5003047676 @default.
• W2142469321 creator A5004887935 @default.
• W2142469321 creator A5010189265 @default.
• W2142469321 creator A5014647041 @default.
• W2142469321 creator A5022580112 @default.
• W2142469321 creator A5032437816 @default.
• W2142469321 creator A5034204710 @default.
• W2142469321 creator A5035251468 @default.
• W2142469321 creator A5041176579 @default.
• W2142469321 creator A5060079909 @default.
• W2142469321 creator A5070011974 @default.
• W2142469321 date "2005-09-01" @default.
• W2142469321 modified "2023-10-11" @default.
• W2142469321 title "Apolipoprotein D is down-regulated during malignant transformation of neurofibromas" @default.
• W2142469321 cites W106404930 @default.
• W2142469321 cites W1510677006 @default.
• W2142469321 cites W1563058663 @default.
• W2142469321 cites W1583038422 @default.
• W2142469321 cites W1586091975 @default.
• W2142469321 cites W1606749110 @default.
• W2142469321 cites W1639841189 @default.
• W2142469321 cites W1775613062 @default.
• W2142469321 cites W1966453709 @default.
• W2142469321 cites W1966507802 @default.
• W2142469321 cites W1969882144 @default.
• W2142469321 cites W1982012806 @default.
• W2142469321 cites W1983052307 @default.
• W2142469321 cites W1985028322 @default.
• W2142469321 cites W1989856647 @default.
• W2142469321 cites W1990161819 @default.
• W2142469321 cites W1992013240 @default.
• W2142469321 cites W1996773648 @default.
• W2142469321 cites W2001927863 @default.
• W2142469321 cites W2012543064 @default.
• W2142469321 cites W2013267369 @default.
• W2142469321 cites W2016361058 @default.
• W2142469321 cites W2020231002 @default.
• W2142469321 cites W202730752 @default.
• W2142469321 cites W2034632458 @default.
• W2142469321 cites W2041140837 @default.
• W2142469321 cites W2041714098 @default.
• W2142469321 cites W2051685564 @default.
• W2142469321 cites W2067782768 @default.
• W2142469321 cites W2069886811 @default.
• W2142469321 cites W2076942739 @default.
• W2142469321 cites W2083179056 @default.
• W2142469321 cites W2087404852 @default.
• W2142469321 cites W2091656893 @default.
• W2142469321 cites W2107277218 @default.
• W2142469321 cites W2117558653 @default.
• W2142469321 cites W2121733985 @default.
• W2142469321 cites W2125547572 @default.
• W2142469321 cites W2144854612 @default.
• W2142469321 cites W2150932906 @default.
• W2142469321 cites W2155122194 @default.
• W2142469321 cites W2157575236 @default.
• W2142469321 cites W2164711789 @default.
• W2142469321 cites W22062734 @default.
• W2142469321 cites W2302679355 @default.
• W2142469321 cites W2405473145 @default.
• W2142469321 doi "https://doi.org/10.1016/j.humpath.2005.06.018" @default.
• W2142469321 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16153462" @default.
• W2142469321 hasPublicationYear "2005" @default.
• W2142469321 type Work @default.
• W2142469321 sameAs 2142469321 @default.
• W2142469321 citedByCount "12" @default.
• W2142469321 countsByYear W21424693212012 @default.
• W2142469321 countsByYear W21424693212013 @default.
• W2142469321 countsByYear W21424693212016 @default.
• W2142469321 countsByYear W21424693212020 @default.
• W2142469321 countsByYear W21424693212021 @default.
• W2142469321 crossrefType "journal-article" @default.
• W2142469321 hasAuthorship W2142469321A5003047676 @default.
• W2142469321 hasAuthorship W2142469321A5004887935 @default.
• W2142469321 hasAuthorship W2142469321A5010189265 @default.
• W2142469321 hasAuthorship W2142469321A5014647041 @default.
• W2142469321 hasAuthorship W2142469321A5022580112 @default.
• W2142469321 hasAuthorship W2142469321A5032437816 @default.
• W2142469321 hasAuthorship W2142469321A5034204710 @default.
• W2142469321 hasAuthorship W2142469321A5035251468 @default.
• W2142469321 hasAuthorship W2142469321A5041176579 @default.
• W2142469321 hasAuthorship W2142469321A5060079909 @default.
• W2142469321 hasAuthorship W2142469321A5070011974 @default.
• W2142469321 hasConcept C104317684 @default.
• W2142469321 hasConcept C105580179 @default.
• W2142469321 hasConcept C121608353 @default.
• W2142469321 hasConcept C142724271 @default.
• W2142469321 hasConcept C204232928 @default.
• W2142469321 hasConcept C31033888 @default.
• W2142469321 hasConcept C54355233 @default.
• W2142469321 hasConcept C55493867 @default.
• W2142469321 hasConcept C555283112 @default.
• W2142469321 hasConcept C71924100 @default.
• W2142469321 hasConcept C81439078 @default.
• W2142469321 hasConcept C86803240 @default.
• W2142469321 hasConceptScore W2142469321C104317684 @default.

• next