FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142471561> ?p ?o ?g. }

• W2142471561 endingPage "2924" @default.
• W2142471561 startingPage "2916" @default.
• W2142471561 abstract "The posttranscriptional insertion and deletion of U residues in trypanosome mitochondrial transcripts called RNA editing initiates at the 3' end of precisely defined editing domains that can be identified independently of the cognate guide RNA. The regions where editing initiates in Trypanosoma brucei cytochrome b and cytochrome oxidase subunit II preedited mRNAs are specifically cleaved by a trypanosome mitochondrial endonuclease that acts like mung bean nuclease and therefore is single strand specific. The regions where editing initiates in virtually all examined preedited mRNAs are predicted to form loop structures, suggesting that editing domains could generally be recognized as prominent single-stranded loops. In contrast to preedited mRNA, edited mRNA can be either resistant or sensitive to cleavage by trypanosome mitochondrial endonuclease, depending on the reaction conditions. This selectivity appears dependent on the availability of extract RNAs, and in model reactions, edited mRNA becomes resistant to cleavage upon base pairing with its guide RNA. Natural partially edited mRNAs are also specifically cleaved with a sensitivity like preedited and unlike edited mRNAs, consistent with their being intermediates in editing. These results suggest that in vivo, the structure of editing domains could initially be recognized by the mitochondrial endonuclease, which could target its associated RNA ligase and terminal U transferase to begin cycles of enzymatic editing modifications." @default.
• W2142471561 created "2016-06-24" @default.
• W2142471561 creator A5011823990 @default.
• W2142471561 creator A5012071618 @default.
• W2142471561 creator A5023909283 @default.
• W2142471561 creator A5037717192 @default.
• W2142471561 creator A5062409481 @default.
• W2142471561 creator A5085360260 @default.
• W2142471561 date "1995-06-01" @default.
• W2142471561 modified "2023-09-26" @default.
• W2142471561 title "Editing Domains of <i>Trypanosoma brucei</i> Mitochondrial RNAs Identified by Secondary Structure" @default.
• W2142471561 cites W1499162785 @default.
• W2142471561 cites W1504724932 @default.
• W2142471561 cites W1524970720 @default.
• W2142471561 cites W1534643095 @default.
• W2142471561 cites W1790527661 @default.
• W2142471561 cites W1892019602 @default.
• W2142471561 cites W1919664101 @default.
• W2142471561 cites W1934766143 @default.
• W2142471561 cites W1935059966 @default.
• W2142471561 cites W1966123063 @default.
• W2142471561 cites W1966857238 @default.
• W2142471561 cites W1969769090 @default.
• W2142471561 cites W1970667469 @default.
• W2142471561 cites W1981556636 @default.
• W2142471561 cites W1987829323 @default.
• W2142471561 cites W2025763720 @default.
• W2142471561 cites W2028505310 @default.
• W2142471561 cites W2033515562 @default.
• W2142471561 cites W2035230667 @default.
• W2142471561 cites W2068683905 @default.
• W2142471561 cites W2068861284 @default.
• W2142471561 cites W2080653091 @default.
• W2142471561 cites W2084211101 @default.
• W2142471561 cites W2088364543 @default.
• W2142471561 cites W2128972342 @default.
• W2142471561 cites W2129267739 @default.
• W2142471561 cites W2143653514 @default.
• W2142471561 cites W2144929331 @default.
• W2142471561 cites W2145201794 @default.
• W2142471561 cites W2145594096 @default.
• W2142471561 cites W2150857251 @default.
• W2142471561 cites W2151424128 @default.
• W2142471561 cites W2154142754 @default.
• W2142471561 cites W2157615575 @default.
• W2142471561 cites W2166178374 @default.
• W2142471561 cites W2166803405 @default.
• W2142471561 cites W2170107692 @default.
• W2142471561 cites W2264429446 @default.
• W2142471561 cites W4234510935 @default.
• W2142471561 doi "https://doi.org/10.1128/mcb.15.6.2916" @default.
• W2142471561 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/230522" @default.
• W2142471561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7539099" @default.
• W2142471561 hasPublicationYear "1995" @default.
• W2142471561 type Work @default.
• W2142471561 sameAs 2142471561 @default.
• W2142471561 citedByCount "24" @default.
• W2142471561 countsByYear W21424715612012 @default.
• W2142471561 countsByYear W21424715612014 @default.
• W2142471561 countsByYear W21424715612022 @default.
• W2142471561 crossrefType "journal-article" @default.
• W2142471561 hasAuthorship W2142471561A5011823990 @default.
• W2142471561 hasAuthorship W2142471561A5012071618 @default.
• W2142471561 hasAuthorship W2142471561A5023909283 @default.
• W2142471561 hasAuthorship W2142471561A5037717192 @default.
• W2142471561 hasAuthorship W2142471561A5062409481 @default.
• W2142471561 hasAuthorship W2142471561A5085360260 @default.
• W2142471561 hasBestOaLocation W21424715612 @default.
• W2142471561 hasConcept C104317684 @default.
• W2142471561 hasConcept C105580179 @default.
• W2142471561 hasConcept C141231307 @default.
• W2142471561 hasConcept C144501496 @default.
• W2142471561 hasConcept C153911025 @default.
• W2142471561 hasConcept C21786251 @default.
• W2142471561 hasConcept C2777028655 @default.
• W2142471561 hasConcept C2777271071 @default.
• W2142471561 hasConcept C2779502636 @default.
• W2142471561 hasConcept C54355233 @default.
• W2142471561 hasConcept C552990157 @default.
• W2142471561 hasConcept C67705224 @default.
• W2142471561 hasConcept C86803240 @default.
• W2142471561 hasConcept C97702854 @default.
• W2142471561 hasConceptScore W2142471561C104317684 @default.
• W2142471561 hasConceptScore W2142471561C105580179 @default.
• W2142471561 hasConceptScore W2142471561C141231307 @default.
• W2142471561 hasConceptScore W2142471561C144501496 @default.
• W2142471561 hasConceptScore W2142471561C153911025 @default.
• W2142471561 hasConceptScore W2142471561C21786251 @default.
• W2142471561 hasConceptScore W2142471561C2777028655 @default.
• W2142471561 hasConceptScore W2142471561C2777271071 @default.
• W2142471561 hasConceptScore W2142471561C2779502636 @default.
• W2142471561 hasConceptScore W2142471561C54355233 @default.
• W2142471561 hasConceptScore W2142471561C552990157 @default.
• W2142471561 hasConceptScore W2142471561C67705224 @default.
• W2142471561 hasConceptScore W2142471561C86803240 @default.
• W2142471561 hasConceptScore W2142471561C97702854 @default.
• W2142471561 hasIssue "6" @default.
• W2142471561 hasLocation W21424715611 @default.

• next