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• W2142489516 abstract "Conventional non-biologic systemic agents are regarded as second-line therapy for the treatment of moderate-to-severe plaque psoriasis after topical treatments. However, long-term data have highlighted a number of safety concerns associated with their prolonged use. Biologic agents targeting specific immune mediators have emerged as an alternative treatment option for patients with moderate-to-severe plaque psoriasis who are unresponsive to, or intolerant of, non-biologic systemic agents. Although several biologics have demonstrated good efficacy and tolerability in short-term trials, treatment guidelines recommend them as third-line therapies due to a relative lack of long-term safety data. Here, we have reviewed the long-term (≥ 1 year) safety data from randomized controlled trials, open-label extension studies and meta-analyses of etanercept, infliximab, efalizumab, adalimumab, alefacept and ustekinumab in the treatment of adults with moderate-to-severe plaque psoriasis. With the exception of efalizumab, which has been withdrawn from both the European and U.S. markets due to long-term safety concerns, these biologics are generally well tolerated in long-term studies, and offer a viable alternative to conventional non-biologic agents in patients with moderate-to-severe plaque psoriasis." @default.
• W2142489516 created "2016-06-24" @default.
• W2142489516 creator A5088303445 @default.
• W2142489516 date "2012-10-22" @default.
• W2142489516 modified "2023-10-13" @default.
• W2142489516 title "Long-term safety of biologics in the treatment of moderate-to-severe plaque psoriasis: review of current data" @default.
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• W2142489516 doi "https://doi.org/10.1111/j.1365-2133.2012.11208.x" @default.
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