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• W2142490129 abstract "Abstract— MAO of human brain and liver mitochondria was solubilized by a procedure that preserved the substrate and inhibitor selectivities of the original mitochondrial preparation. Techniques that are designed to separate proteins on the basis of molecular size or net surface charge did not yield a physical separation of enzymically active A and B forms, even in the presence of ionic detergents or with limited proteolysis. However, sulfhydryl inhibitors, inorganic salts, ionic detergents, heat treatment, and sonication all tended to cause selective inactivation of serotonin-metabolizing activity in solubilized preparations. Experiments with selectively inhibited (membrane-bound or solubilized) MAO supported the concept of at least two independent kinds of substrate binding site, only one of which metabolizes serotonin (A type) and another (B type) which has a very strong affinity for β-phenethylamine. l-Norepinephrine, tryptamine, dopamine, and tyramine could be classified as common substrates. The lowest Km values were found for tryptamine at A sites and for β-phenethylamine at B sites. Results of this study suggest that the different MAO sites could be part of the same large molecular complex, which may normally be embedded in the outer mitochondrial membrane so that A sites are more dependent on their lipid environment within this membrane." @default.
• W2142490129 created "2016-06-24" @default.
• W2142490129 creator A5084317249 @default.
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• W2142490129 date "1977-12-01" @default.
• W2142490129 modified "2023-10-16" @default.
• W2142490129 title "MULTIPLE BINDING SITES OF HUMAN BRAIN AND LIVER MONOAMINE OXIDASE: SUBSTRATE SPECIFICITIES, SELECTIVE INHIBITIONS, AND ATTEMPTS TO SEPARATE ENZYME FORMS" @default.
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• W2142490129 doi "https://doi.org/10.1111/j.1471-4159.1977.tb06502.x" @default.
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