Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142490432> ?p ?o ?g. }
- W2142490432 endingPage "372" @default.
- W2142490432 startingPage "343" @default.
- W2142490432 abstract "Translational bypassing joins the information found within two disparate open reading frames into a single polypeptide chain. The underlying mechanism centers on the decoding properties of peptidyl-transfer RNA (tRNA) and involves three stages: take-off, scanning, and landing. In take-off, the peptidyl-tRNA/messenger RNA (mRNA) complex in the P site of the ribosome dissociates, and the mRNA begins to move through the ribosome. In scanning, the peptidyl-tRNA probes the mRNA sliding through the decoding center. In landing, the peptidyl-tRNA re-pairs with a codon with which it can form a stable interaction. Although few examples of genes are known that rely on translational bypassing to couple open reading frames, ribosomes appear to have an innate capacity for bypassing. This suggests that the strategy of translational bypassing may be more common than presently appreciated. The best characterized example of this phenomenon is T4 gene 60, in which a complex set of signals stimulates bypassing of 50 nucleotides between the two open reading frames. In this review, we focus on the bypassing mechanism of gene 60 in terms of take-off, scanning, and landing." @default.
- W2142490432 created "2016-06-24" @default.
- W2142490432 creator A5022276406 @default.
- W2142490432 creator A5027623305 @default.
- W2142490432 creator A5033458397 @default.
- W2142490432 date "2000-06-01" @default.
- W2142490432 modified "2023-09-24" @default.
- W2142490432 title "Coupling of Open Reading Frames by Translational Bypassing" @default.
- W2142490432 cites W1493061537 @default.
- W2142490432 cites W1494091714 @default.
- W2142490432 cites W1502052224 @default.
- W2142490432 cites W152630325 @default.
- W2142490432 cites W1557352560 @default.
- W2142490432 cites W1575723743 @default.
- W2142490432 cites W1579537489 @default.
- W2142490432 cites W1579730392 @default.
- W2142490432 cites W1596798734 @default.
- W2142490432 cites W1599555369 @default.
- W2142490432 cites W1606305585 @default.
- W2142490432 cites W1607797981 @default.
- W2142490432 cites W1610825815 @default.
- W2142490432 cites W1643121191 @default.
- W2142490432 cites W1774105245 @default.
- W2142490432 cites W185828536 @default.
- W2142490432 cites W1868347993 @default.
- W2142490432 cites W1937771595 @default.
- W2142490432 cites W1969758655 @default.
- W2142490432 cites W1970097134 @default.
- W2142490432 cites W1979103958 @default.
- W2142490432 cites W1985536456 @default.
- W2142490432 cites W1989951440 @default.
- W2142490432 cites W1991657860 @default.
- W2142490432 cites W1993593524 @default.
- W2142490432 cites W1993818423 @default.
- W2142490432 cites W1995080581 @default.
- W2142490432 cites W1996592126 @default.
- W2142490432 cites W2000149667 @default.
- W2142490432 cites W2008025258 @default.
- W2142490432 cites W2013958637 @default.
- W2142490432 cites W2018892536 @default.
- W2142490432 cites W2021761289 @default.
- W2142490432 cites W2022895983 @default.
- W2142490432 cites W2025641516 @default.
- W2142490432 cites W2029198202 @default.
- W2142490432 cites W2034336251 @default.
- W2142490432 cites W2034351685 @default.
- W2142490432 cites W2041816583 @default.
- W2142490432 cites W2041913199 @default.
- W2142490432 cites W2042508815 @default.
- W2142490432 cites W2043624772 @default.
- W2142490432 cites W2044553149 @default.
- W2142490432 cites W2046187851 @default.
- W2142490432 cites W2052840366 @default.
- W2142490432 cites W2055553278 @default.
- W2142490432 cites W2056674309 @default.
- W2142490432 cites W2057014596 @default.
- W2142490432 cites W2061714392 @default.
- W2142490432 cites W2061856039 @default.
- W2142490432 cites W2062900004 @default.
- W2142490432 cites W2071505280 @default.
- W2142490432 cites W2072447119 @default.
- W2142490432 cites W2072962648 @default.
- W2142490432 cites W2074190628 @default.
- W2142490432 cites W2075282900 @default.
- W2142490432 cites W2077034524 @default.
- W2142490432 cites W2077480952 @default.
- W2142490432 cites W2078758045 @default.
- W2142490432 cites W2080054708 @default.
- W2142490432 cites W2084140927 @default.
- W2142490432 cites W2084727384 @default.
- W2142490432 cites W2086830419 @default.
- W2142490432 cites W2087031768 @default.
- W2142490432 cites W2092409836 @default.
- W2142490432 cites W2092729902 @default.
- W2142490432 cites W2094853570 @default.
- W2142490432 cites W2103401990 @default.
- W2142490432 cites W2105500181 @default.
- W2142490432 cites W2112642778 @default.
- W2142490432 cites W2118286480 @default.
- W2142490432 cites W2118391959 @default.
- W2142490432 cites W2120311490 @default.
- W2142490432 cites W2127264165 @default.
- W2142490432 cites W2132549793 @default.
- W2142490432 cites W2136136168 @default.
- W2142490432 cites W2138807356 @default.
- W2142490432 cites W2139476768 @default.
- W2142490432 cites W2148382456 @default.
- W2142490432 cites W2153566143 @default.
- W2142490432 cites W2160600702 @default.
- W2142490432 cites W2167039974 @default.
- W2142490432 cites W2170885481 @default.
- W2142490432 cites W2198612891 @default.
- W2142490432 cites W2325916690 @default.
- W2142490432 cites W2338593700 @default.
- W2142490432 cites W2414700665 @default.
- W2142490432 cites W2418466522 @default.
- W2142490432 cites W242744019 @default.
- W2142490432 cites W260593641 @default.