FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142517472> ?p ?o ?g. }

• W2142517472 endingPage "133" @default.
• W2142517472 startingPage "128" @default.
• W2142517472 abstract "Pandemic influenza A/H1N1 (2009) and avian influenza A/H5N1 neuraminidase (NA) differ at two critical residues, positions 149 and 347. Recombinant influenza A viruses were constructed in which these two residues in pandemic influenza A/H1N1 (2009) NA were changed to the corresponding amino acids of avian influenza A/H5N1 NA, and vice versa. Recombinant viruses bearing N1 NA with the oseltamivir resistance mutation H274Y in combination with mutations at residues 149 and 347 were also constructed. Recombinant viruses grew normally in allantoic fluid and were subsequently studied for viral infectivity (TCID50), substrate binding (Km) and sensitivity to oseltamivir (Ki). The data demonstrated that infectivity of mutant viruses in Madin Darby canine kidney cells was comparable to, or even greater than, the infectivity of the parental viruses harboring wild-type N1 NA. Furthermore, mutations at NA residues 149 and 347 altered Km and Ki values, and thus modulated oseltamivir sensitivity. Although these mutants have yet to be observed among natural isolates, the minimal costs to the growth of recombinant viruses indicate their possible viability. Reassortment between pandemic influenza A/H1N1 (2009) and avian influenza A/H5N1 viruses may therefore generate new influenza A viruses with increased infectivity and oseltamivir resistance, and continued surveillance will be crucial for public health preparedness." @default.
• W2142517472 created "2016-06-24" @default.
• W2142517472 creator A5003221689 @default.
• W2142517472 creator A5028706639 @default.
• W2142517472 creator A5030075748 @default.
• W2142517472 creator A5036500920 @default.
• W2142517472 creator A5036767879 @default.
• W2142517472 creator A5057659627 @default.
• W2142517472 date "2013-08-01" @default.
• W2142517472 modified "2023-09-23" @default.
• W2142517472 title "Neuraminidase amino acids 149 and 347 determine the infectivity and oseltamivir sensitivity of pandemic influenza A/H1N1 (2009) and avian influenza A/H5N1" @default.
• W2142517472 cites W120824281 @default.
• W2142517472 cites W1981832761 @default.
• W2142517472 cites W1988044361 @default.
• W2142517472 cites W1992726907 @default.
• W2142517472 cites W1994538071 @default.
• W2142517472 cites W1994644330 @default.
• W2142517472 cites W1999703541 @default.
• W2142517472 cites W2001211237 @default.
• W2142517472 cites W2002507072 @default.
• W2142517472 cites W2044965105 @default.
• W2142517472 cites W2046094044 @default.
• W2142517472 cites W2046745698 @default.
• W2142517472 cites W2050776967 @default.
• W2142517472 cites W2057700014 @default.
• W2142517472 cites W2075495833 @default.
• W2142517472 cites W2107651145 @default.
• W2142517472 cites W2128284760 @default.
• W2142517472 cites W2143029493 @default.
• W2142517472 cites W2145320830 @default.
• W2142517472 cites W2157356342 @default.
• W2142517472 cites W2159524042 @default.
• W2142517472 cites W2160079547 @default.
• W2142517472 cites W2169759517 @default.
• W2142517472 cites W2582620890 @default.
• W2142517472 cites W4293247451 @default.
• W2142517472 doi "https://doi.org/10.1016/j.virusres.2013.04.011" @default.
• W2142517472 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23639424" @default.
• W2142517472 hasPublicationYear "2013" @default.
• W2142517472 type Work @default.
• W2142517472 sameAs 2142517472 @default.
• W2142517472 citedByCount "4" @default.
• W2142517472 countsByYear W21425174722015 @default.
• W2142517472 countsByYear W21425174722016 @default.
• W2142517472 countsByYear W21425174722018 @default.
• W2142517472 countsByYear W21425174722020 @default.
• W2142517472 crossrefType "journal-article" @default.
• W2142517472 hasAuthorship W2142517472A5003221689 @default.
• W2142517472 hasAuthorship W2142517472A5028706639 @default.
• W2142517472 hasAuthorship W2142517472A5030075748 @default.
• W2142517472 hasAuthorship W2142517472A5036500920 @default.
• W2142517472 hasAuthorship W2142517472A5036767879 @default.
• W2142517472 hasAuthorship W2142517472A5057659627 @default.
• W2142517472 hasConcept C104317684 @default.
• W2142517472 hasConcept C106358424 @default.
• W2142517472 hasConcept C134164806 @default.
• W2142517472 hasConcept C142724271 @default.
• W2142517472 hasConcept C159047783 @default.
• W2142517472 hasConcept C16154277 @default.
• W2142517472 hasConcept C2522874641 @default.
• W2142517472 hasConcept C2777538117 @default.
• W2142517472 hasConcept C2777546802 @default.
• W2142517472 hasConcept C2779134260 @default.
• W2142517472 hasConcept C2780374985 @default.
• W2142517472 hasConcept C3008058167 @default.
• W2142517472 hasConcept C40767141 @default.
• W2142517472 hasConcept C519248777 @default.
• W2142517472 hasConcept C524204448 @default.
• W2142517472 hasConcept C54355233 @default.
• W2142517472 hasConcept C71924100 @default.
• W2142517472 hasConcept C82988372 @default.
• W2142517472 hasConcept C86803240 @default.
• W2142517472 hasConcept C89423630 @default.
• W2142517472 hasConcept C89623803 @default.
• W2142517472 hasConceptScore W2142517472C104317684 @default.
• W2142517472 hasConceptScore W2142517472C106358424 @default.
• W2142517472 hasConceptScore W2142517472C134164806 @default.
• W2142517472 hasConceptScore W2142517472C142724271 @default.
• W2142517472 hasConceptScore W2142517472C159047783 @default.
• W2142517472 hasConceptScore W2142517472C16154277 @default.
• W2142517472 hasConceptScore W2142517472C2522874641 @default.
• W2142517472 hasConceptScore W2142517472C2777538117 @default.
• W2142517472 hasConceptScore W2142517472C2777546802 @default.
• W2142517472 hasConceptScore W2142517472C2779134260 @default.
• W2142517472 hasConceptScore W2142517472C2780374985 @default.
• W2142517472 hasConceptScore W2142517472C3008058167 @default.
• W2142517472 hasConceptScore W2142517472C40767141 @default.
• W2142517472 hasConceptScore W2142517472C519248777 @default.
• W2142517472 hasConceptScore W2142517472C524204448 @default.
• W2142517472 hasConceptScore W2142517472C54355233 @default.
• W2142517472 hasConceptScore W2142517472C71924100 @default.
• W2142517472 hasConceptScore W2142517472C82988372 @default.
• W2142517472 hasConceptScore W2142517472C86803240 @default.
• W2142517472 hasConceptScore W2142517472C89423630 @default.
• W2142517472 hasConceptScore W2142517472C89623803 @default.
• W2142517472 hasIssue "2" @default.
• W2142517472 hasLocation W21425174721 @default.
• W2142517472 hasLocation W21425174722 @default.

• next