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- W2142549612 abstract "Sangre de grado is an ethnomedicinal red tree sap obtained from Croton spp. that is used to treat gastrointestinal ulcers, cancer and to promote wound healing. To evaluate the potential role of sangre de grado (SdG) in cancer we examined its effects on human cancer cells, AGS (stomach), HT29 and T84 (colon). Viability of cells treated with SdG (10–200 μg/ml) decreased (P<0.01) in a dose dependent manner measured over a 24-h period. Cell proliferation at 48 h decreased (P<0.01) in all cells treated with SdG (>100 μg/ml). When cells in suspension were treated with SdG (100 μg/ml) cell adherence was severely compromised (>85%). Cells treated with SdG (100 μg/ml) underwent apoptosis as detected by nucleus condensation and DNA fragmentation determined by ELISA, and flow cytometry. Morphological changes as assessed by acridine orange. These effects were similar to that observed with Taxol (30 μM). A significant alteration of microtubular architecture was equally observed in both stomach and colon cancer cells exposed to SdG (100 μg/ml). The induction of apoptosis and microtubule damage in AGS, HT29 and T84 cells suggest that sangre de grado should be evaluated further as a potential source of anti-cancer agents." @default.
- W2142549612 created "2016-06-24" @default.
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- W2142549612 date "2002-05-01" @default.
- W2142549612 modified "2023-10-18" @default.
- W2142549612 title "Sangre de grado Croton palanostigma induces apoptosis in human gastrointestinal cancer cells" @default.
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- W2142549612 doi "https://doi.org/10.1016/s0378-8741(02)00013-2" @default.
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