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• W2142552972 abstract "A novel series of 1,2-benzisothiazol-3-one derivatives was synthesized and their biological activities were evaluated for inhibiting caspase-3 and -7 activities, in which some of them showed low nanomolar potency against caspase-3 in vitro and significant protection against apoptosis in a camptothecin-induced Jurkat T cells system. Among the tested compounds, compound 5i exhibited the most potent caspase-3 inhibitory activity (IC50=1.15 nM). The molecular docking predicted the interactions and binding modes of the synthesized inhibitor in the caspase-3 active site." @default.
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• W2142552972 date "2014-04-01" @default.
• W2142552972 modified "2023-10-06" @default.
• W2142552972 title "1,2-Benzisothiazol-3-one derivatives as a novel class of small-molecule caspase-3 inhibitors" @default.
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• W2142552972 doi "https://doi.org/10.1016/j.bmc.2014.03.002" @default.
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