Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142554708> ?p ?o ?g. }
- W2142554708 endingPage "8320" @default.
- W2142554708 startingPage "8314" @default.
- W2142554708 abstract "Abstract Purpose: Signal transducer and activator of transcription 5 (STAT5) and STAT3 oppose one another in regulation of the reciprocal development of CD4+CD25+FOXP3+ regulatory T cells (Treg) and T helper 17 (Th17). A reduction in STAT3 is associated with up-regulation of Treg, and STAT5 activation promotes Treg differentiation or function while constraining Th17 generation. The effects of IFNα on STAT signaling in relation to tumor tissue Treg and Th17 have not been documented in humans beyond the observations that IFNα2b down-regulates STAT3. Experimental Design: Following diagnostic biopsy and before definitive surgery, 20 doses of high-dose IFNα2b (HDI) were administered to patients with stage IIIB melanoma who gave written informed consent. Lymph node biopsies, in which both total STAT3 and phosphorylated STAT3 were down-regulated by HDI, were probed with STAT5, FOXP3, CD4, and interleukin 17 (IL-17) with immunohistochemistry and/or immunofluorescence techniques. Results: The percentage of FOXP3+ lymphocytes determined by immunohistochemistry was up-regulated from 3.06 ± 0.65% to 9.86 ± 1.27% (n = 13, P = 0.0002), and this observation was confirmed by immunofluorescence evaluation of CD4+FOXP3+ Tregs. HDI induced STAT5 up-regulation (five cases observed) in melanoma cells and lymphocytes but did not induce the generation of IL-17–expressing lymphocytes. Increased STAT5 expression was associated with increased FOXP3 expression among lymphocytes, and STAT5 was constitutively activated among both melanoma cells and lymphocytes. Conclusion: IFNα2b up-regulates STAT5 and down-regulates STAT3, in conjunction with up-regulation of Treg and inhibition of IL-17–expressing lymphocytes in melanoma tissues. These findings suggest that the effects of IFNα may be potentiated through interference with the response of Tregs and/or STAT5." @default.
- W2142554708 created "2016-06-24" @default.
- W2142554708 creator A5002316087 @default.
- W2142554708 creator A5007239425 @default.
- W2142554708 creator A5008077469 @default.
- W2142554708 creator A5033020983 @default.
- W2142554708 creator A5042944491 @default.
- W2142554708 creator A5046978138 @default.
- W2142554708 creator A5047383033 @default.
- W2142554708 date "2008-12-15" @default.
- W2142554708 modified "2023-10-03" @default.
- W2142554708 title "Effects of High-Dose IFNα2b on Regional Lymph Node Metastases of Human Melanoma: Modulation of STAT5, FOXP3, and IL-17" @default.
- W2142554708 cites W1517826228 @default.
- W2142554708 cites W1526933908 @default.
- W2142554708 cites W1828940258 @default.
- W2142554708 cites W1830155866 @default.
- W2142554708 cites W1878828051 @default.
- W2142554708 cites W1969234386 @default.
- W2142554708 cites W1976591271 @default.
- W2142554708 cites W1979390267 @default.
- W2142554708 cites W1980927217 @default.
- W2142554708 cites W1981298448 @default.
- W2142554708 cites W1984677655 @default.
- W2142554708 cites W1985126564 @default.
- W2142554708 cites W1985406652 @default.
- W2142554708 cites W1992547979 @default.
- W2142554708 cites W1999468766 @default.
- W2142554708 cites W2000375474 @default.
- W2142554708 cites W2000520554 @default.
- W2142554708 cites W2004708987 @default.
- W2142554708 cites W2008713912 @default.
- W2142554708 cites W2015544673 @default.
- W2142554708 cites W2037259928 @default.
- W2142554708 cites W2073672027 @default.
- W2142554708 cites W2078574377 @default.
- W2142554708 cites W2082218262 @default.
- W2142554708 cites W2098267542 @default.
- W2142554708 cites W2098983864 @default.
- W2142554708 cites W2101003487 @default.
- W2142554708 cites W2102293090 @default.
- W2142554708 cites W2106471879 @default.
- W2142554708 cites W2107867811 @default.
- W2142554708 cites W2112410464 @default.
- W2142554708 cites W2116871245 @default.
- W2142554708 cites W2118449798 @default.
- W2142554708 cites W2123166427 @default.
- W2142554708 cites W2126722705 @default.
- W2142554708 cites W2139153458 @default.
- W2142554708 cites W2141785549 @default.
- W2142554708 cites W2143923888 @default.
- W2142554708 cites W2144081036 @default.
- W2142554708 cites W2147090478 @default.
- W2142554708 cites W2155779547 @default.
- W2142554708 cites W2166282414 @default.
- W2142554708 cites W2169820627 @default.
- W2142554708 cites W4256189622 @default.
- W2142554708 cites W4323053376 @default.
- W2142554708 doi "https://doi.org/10.1158/1078-0432.ccr-08-0705" @default.
- W2142554708 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19088050" @default.
- W2142554708 hasPublicationYear "2008" @default.
- W2142554708 type Work @default.
- W2142554708 sameAs 2142554708 @default.
- W2142554708 citedByCount "32" @default.
- W2142554708 countsByYear W21425547082012 @default.
- W2142554708 countsByYear W21425547082013 @default.
- W2142554708 countsByYear W21425547082014 @default.
- W2142554708 countsByYear W21425547082015 @default.
- W2142554708 countsByYear W21425547082016 @default.
- W2142554708 countsByYear W21425547082018 @default.
- W2142554708 countsByYear W21425547082019 @default.
- W2142554708 countsByYear W21425547082020 @default.
- W2142554708 countsByYear W21425547082022 @default.
- W2142554708 crossrefType "journal-article" @default.
- W2142554708 hasAuthorship W2142554708A5002316087 @default.
- W2142554708 hasAuthorship W2142554708A5007239425 @default.
- W2142554708 hasAuthorship W2142554708A5008077469 @default.
- W2142554708 hasAuthorship W2142554708A5033020983 @default.
- W2142554708 hasAuthorship W2142554708A5042944491 @default.
- W2142554708 hasAuthorship W2142554708A5046978138 @default.
- W2142554708 hasAuthorship W2142554708A5047383033 @default.
- W2142554708 hasBestOaLocation W21425547081 @default.
- W2142554708 hasConcept C126322002 @default.
- W2142554708 hasConcept C159654299 @default.
- W2142554708 hasConcept C170493617 @default.
- W2142554708 hasConcept C171958077 @default.
- W2142554708 hasConcept C203014093 @default.
- W2142554708 hasConcept C204232928 @default.
- W2142554708 hasConcept C2776090121 @default.
- W2142554708 hasConcept C2777658100 @default.
- W2142554708 hasConcept C2778236600 @default.
- W2142554708 hasConcept C2778277574 @default.
- W2142554708 hasConcept C2778690821 @default.
- W2142554708 hasConcept C2778923194 @default.
- W2142554708 hasConcept C2779391668 @default.
- W2142554708 hasConcept C2779727006 @default.
- W2142554708 hasConcept C502942594 @default.
- W2142554708 hasConcept C62478195 @default.
- W2142554708 hasConcept C71924100 @default.