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• W2142569062 abstract "Imatinib, the ABL kinase inhibitor, is used not only for Philadelphia chromosome-positive (Ph + ) chronic myelogenous leukemia, but also for Ph + acute lymphoblastic leukemia (ALL), although resistance to the drug tends to develop in an early stage of the clinical course. We describe a childhood refractory Ph + ALL patient in whom progressive resistance to imatinib was correlated with the appearance of a mutation in the BCR-ABL kinase domain and in vitro drug resistance to imatinib as determined by the methyl-thiazol-tetrazolium (MTT) assay. A missense mutation of T to C (Y253H) of the ABL gene was identified in the resistant clone, suggesting that this mutation may play an etiological role in the rapid loss of drug sensitivity." @default.
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• W2142569062 date "2005-01-01" @default.
• W2142569062 modified "2023-10-03" @default.
• W2142569062 title "In vitrodrug resistance to imatinib and mutation ofABLgene in childhood Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia" @default.
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• W2142569062 doi "https://doi.org/10.1080/10428190400011609" @default.
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