FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142583671> ?p ?o ?g. }

• W2142583671 endingPage "3712" @default.
• W2142583671 startingPage "3700" @default.
• W2142583671 abstract "ABSTRACT The compartmentalized production of superoxide (·O 2 − ) by endosomal NADPH oxidase is important in the redox-dependent activation of NF-κB following interleukin 1β (IL-1β) stimulation. It remains unclear how ·O 2 − produced within endosomes facilitates redox-dependent signaling events in the cytoplasm. We evaluated ·O 2 − movement out of IL-1β-stimulated endosomes and whether SOD1 at the endosomal surface mediates redox-signaling events required for NF-κB activation. The relative outward permeability of NADPH-dependent ·O 2 − from fractionated endosomes was assessed using membrane-permeable (luminol and lucigenin) and -impermeable (isoluminol) luminescent probes for ·O 2 − . In these studies, ∼60% of ·O 2 − efflux out of endosomes was inhibited by treatment with either of two anion channel blockers, 4′-diisothiocyano-2,2′-disulfonic acid stilbene (DIDS) or niflumic acid (NFA). Furthermore, radioisotopic electrodiffusion flux assays on endomembrane proteoliposomes suggested that ·O 2 − and Cl − are transported through the same DIDS-sensitive channel(s). Rab5-based immunoaffinity isolation of IL-1β-stimulated early endosomes demonstrated SOD1 recruitment to endosomes harboring the IL-1 receptor. Finally, SOD1-deficient cells were found to be defective in their ability to activate NF-κB following IL-1β stimulation. Together, these results suggest that ·O 2 − exits endosomes through a DIDS-sensitive chloride channel(s) and that SOD1-mediated dismutation of ·O 2 − at the endosomal surface may produce the localized H 2 O 2 required for redox-activation of NF-κB." @default.
• W2142583671 created "2016-06-24" @default.
• W2142583671 creator A5001472356 @default.
• W2142583671 creator A5002189140 @default.
• W2142583671 creator A5022115776 @default.
• W2142583671 creator A5069771802 @default.
• W2142583671 creator A5085975282 @default.
• W2142583671 date "2008-06-01" @default.
• W2142583671 modified "2023-09-26" @default.
• W2142583671 title "Evidence for a Superoxide Permeability Pathway in Endosomal Membranes" @default.
• W2142583671 cites W1517859613 @default.
• W2142583671 cites W1566615106 @default.
• W2142583671 cites W1580002784 @default.
• W2142583671 cites W1921965616 @default.
• W2142583671 cites W1969374802 @default.
• W2142583671 cites W1970674037 @default.
• W2142583671 cites W1974966731 @default.
• W2142583671 cites W1978631786 @default.
• W2142583671 cites W1978909523 @default.
• W2142583671 cites W1981921279 @default.
• W2142583671 cites W1985234565 @default.
• W2142583671 cites W1987580811 @default.
• W2142583671 cites W1988310632 @default.
• W2142583671 cites W1996833241 @default.
• W2142583671 cites W2001735713 @default.
• W2142583671 cites W2031079404 @default.
• W2142583671 cites W2042662902 @default.
• W2142583671 cites W2060785208 @default.
• W2142583671 cites W2070495111 @default.
• W2142583671 cites W2078174502 @default.
• W2142583671 cites W2091937188 @default.
• W2142583671 cites W2096901938 @default.
• W2142583671 cites W2102619095 @default.
• W2142583671 cites W2106913297 @default.
• W2142583671 cites W2110068304 @default.
• W2142583671 cites W2114111268 @default.
• W2142583671 cites W2116207791 @default.
• W2142583671 cites W2132826785 @default.
• W2142583671 cites W2150820282 @default.
• W2142583671 doi "https://doi.org/10.1128/mcb.02038-07" @default.
• W2142583671 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2423302" @default.
• W2142583671 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18378695" @default.
• W2142583671 hasPublicationYear "2008" @default.
• W2142583671 type Work @default.
• W2142583671 sameAs 2142583671 @default.
• W2142583671 citedByCount "80" @default.
• W2142583671 countsByYear W21425836712012 @default.
• W2142583671 countsByYear W21425836712013 @default.
• W2142583671 countsByYear W21425836712014 @default.
• W2142583671 countsByYear W21425836712015 @default.
• W2142583671 countsByYear W21425836712016 @default.
• W2142583671 countsByYear W21425836712017 @default.
• W2142583671 countsByYear W21425836712018 @default.
• W2142583671 countsByYear W21425836712019 @default.
• W2142583671 countsByYear W21425836712020 @default.
• W2142583671 countsByYear W21425836712021 @default.
• W2142583671 countsByYear W21425836712022 @default.
• W2142583671 countsByYear W21425836712023 @default.
• W2142583671 crossrefType "journal-article" @default.
• W2142583671 hasAuthorship W2142583671A5001472356 @default.
• W2142583671 hasAuthorship W2142583671A5002189140 @default.
• W2142583671 hasAuthorship W2142583671A5022115776 @default.
• W2142583671 hasAuthorship W2142583671A5069771802 @default.
• W2142583671 hasAuthorship W2142583671A5085975282 @default.
• W2142583671 hasBestOaLocation W21425836712 @default.
• W2142583671 hasConcept C102747710 @default.
• W2142583671 hasConcept C12554922 @default.
• W2142583671 hasConcept C181199279 @default.
• W2142583671 hasConcept C185592680 @default.
• W2142583671 hasConcept C2779533339 @default.
• W2142583671 hasConcept C2779719074 @default.
• W2142583671 hasConcept C2780795997 @default.
• W2142583671 hasConcept C41625074 @default.
• W2142583671 hasConcept C48349386 @default.
• W2142583671 hasConcept C55493867 @default.
• W2142583671 hasConcept C79879829 @default.
• W2142583671 hasConcept C86803240 @default.
• W2142583671 hasConcept C95444343 @default.
• W2142583671 hasConceptScore W2142583671C102747710 @default.
• W2142583671 hasConceptScore W2142583671C12554922 @default.
• W2142583671 hasConceptScore W2142583671C181199279 @default.
• W2142583671 hasConceptScore W2142583671C185592680 @default.
• W2142583671 hasConceptScore W2142583671C2779533339 @default.
• W2142583671 hasConceptScore W2142583671C2779719074 @default.
• W2142583671 hasConceptScore W2142583671C2780795997 @default.
• W2142583671 hasConceptScore W2142583671C41625074 @default.
• W2142583671 hasConceptScore W2142583671C48349386 @default.
• W2142583671 hasConceptScore W2142583671C55493867 @default.
• W2142583671 hasConceptScore W2142583671C79879829 @default.
• W2142583671 hasConceptScore W2142583671C86803240 @default.
• W2142583671 hasConceptScore W2142583671C95444343 @default.
• W2142583671 hasIssue "11" @default.
• W2142583671 hasLocation W21425836711 @default.
• W2142583671 hasLocation W21425836712 @default.
• W2142583671 hasLocation W21425836713 @default.
• W2142583671 hasLocation W21425836714 @default.
• W2142583671 hasOpenAccess W2142583671 @default.
• W2142583671 hasPrimaryLocation W21425836711 @default.

• next