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- W2142588907 abstract "Background: Ultraviolet (UV) B light is an environmental mutagen that induces changes in cutaneous gene expression leading to immune suppression and carcinogenesis. Keratinocytes are a primary target for UVB. Objective: To further delineate UVB-induced gene expression changes in keratinocytes. Methods: cDNA microarray technology was utilized to examine gene expression in normal human KC (NHKC) following 20 mJ cm−2 UVB irradiation. Data was confirmed by semi-quantitative RT-PCR. Results: Microarray analysis revealed 57 genes were upregulated, and 27 genes were downregulated, by at least two-fold following UVB. One downregulated gene was the endogenous angiogenesis inhibitor thrombospondin-1 (TSP-1). Semi-quantitative RT-PCR confirmed persistent downregulation of TSP-1 up to 18 h following UVB. Microarray analysis also revealed upregulation of platelet-derived endothelial cell growth factor (PD-ECGF)—an angiogenesis activator. Conclusion: Our results suggest a gene expression mechanism by which UVB induces an angiogenic switch in keratinocytes. This may represent an important early event promoting neovascularization and growth of cutaneous neoplasms." @default.
- W2142588907 created "2016-06-24" @default.
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- W2142588907 date "2004-05-01" @default.
- W2142588907 modified "2023-09-29" @default.
- W2142588907 title "Microarray analysis of UVB-regulated genes in keratinocytes: downregulation of angiogenesis inhibitor thrombospondin-1" @default.
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- W2142588907 doi "https://doi.org/10.1016/j.jdermsci.2004.01.004" @default.
- W2142588907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15113588" @default.
- W2142588907 hasPublicationYear "2004" @default.
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