FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142598127> ?p ?o ?g. }

• W2142598127 endingPage "19385" @default.
• W2142598127 startingPage "19380" @default.
• W2142598127 abstract "Major histocompatibility complex class II molecules (MHC-II) on antigen presenting cells (APCs) engage the TCR on antigen-specific CD4 T cells, thereby providing the specificity required for T cell priming and the induction of an effective immune response. In this study, we have asked whether antigen-loaded dendritic cells (DCs) that have been in contact with antigen-specific CD4 T cells retain the ability to stimulate additional naïve T cells. We show that encounter with antigen-specific primed CD4 T cells induces the degradation of surface MHC-II in antigen-loaded DCs and inhibits the ability of these DCs to stimulate additional naïve CD4 T cells. Cross-linking with MHC-II mAb as a surrogate for T-cell engagement also inhibits APC function and induces MHC-II degradation by promoting the clustering of MHC-II present in lipid raft membrane microdomains, a process that leads to MHC-II endocytosis and degradation in lysosomes. Encounter of DCs with antigen-specific primed T cells or engagement of MHC-II with antibodies promotes the degradation of both immunologically relevant and irrelevant MHC-II molecules. These data demonstrate that engagement of MHC-II on DCs after encounter with antigen-specific primed CD4 T cells promotes the down-regulation of cell surface MHC-II in DCs, thereby attenuating additional activation of naïve CD4 T cells by these APCs." @default.
• W2142598127 created "2016-06-24" @default.
• W2142598127 creator A5029421637 @default.
• W2142598127 creator A5031819059 @default.
• W2142598127 creator A5088766275 @default.
• W2142598127 date "2012-11-05" @default.
• W2142598127 modified "2023-10-10" @default.
• W2142598127 title "Encounter with antigen-specific primed CD4 T cells promotes MHC class II degradation in dendritic cells" @default.
• W2142598127 cites W1503369148 @default.
• W2142598127 cites W1539488492 @default.
• W2142598127 cites W1661544713 @default.
• W2142598127 cites W1984288819 @default.
• W2142598127 cites W1988105476 @default.
• W2142598127 cites W1990458269 @default.
• W2142598127 cites W1991593737 @default.
• W2142598127 cites W1992249154 @default.
• W2142598127 cites W1993027053 @default.
• W2142598127 cites W1998415250 @default.
• W2142598127 cites W2010883684 @default.
• W2142598127 cites W2010946325 @default.
• W2142598127 cites W2020455973 @default.
• W2142598127 cites W2046265547 @default.
• W2142598127 cites W2049432379 @default.
• W2142598127 cites W2061060052 @default.
• W2142598127 cites W2065042783 @default.
• W2142598127 cites W2076121010 @default.
• W2142598127 cites W2078108429 @default.
• W2142598127 cites W2084795557 @default.
• W2142598127 cites W2087173876 @default.
• W2142598127 cites W2094028293 @default.
• W2142598127 cites W2104595633 @default.
• W2142598127 cites W2106474854 @default.
• W2142598127 cites W2128519954 @default.
• W2142598127 cites W2142424369 @default.
• W2142598127 cites W2143151869 @default.
• W2142598127 cites W2152232523 @default.
• W2142598127 cites W2166676682 @default.
• W2142598127 cites W2174570609 @default.
• W2142598127 doi "https://doi.org/10.1073/pnas.1213868109" @default.
• W2142598127 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3511074" @default.
• W2142598127 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23129633" @default.
• W2142598127 hasPublicationYear "2012" @default.
• W2142598127 type Work @default.
• W2142598127 sameAs 2142598127 @default.
• W2142598127 citedByCount "17" @default.
• W2142598127 countsByYear W21425981272013 @default.
• W2142598127 countsByYear W21425981272015 @default.
• W2142598127 countsByYear W21425981272016 @default.
• W2142598127 countsByYear W21425981272018 @default.
• W2142598127 countsByYear W21425981272019 @default.
• W2142598127 countsByYear W21425981272020 @default.
• W2142598127 countsByYear W21425981272021 @default.
• W2142598127 countsByYear W21425981272022 @default.
• W2142598127 countsByYear W21425981272023 @default.
• W2142598127 crossrefType "journal-article" @default.
• W2142598127 hasAuthorship W2142598127A5029421637 @default.
• W2142598127 hasAuthorship W2142598127A5031819059 @default.
• W2142598127 hasAuthorship W2142598127A5088766275 @default.
• W2142598127 hasBestOaLocation W21425981271 @default.
• W2142598127 hasConcept C100701293 @default.
• W2142598127 hasConcept C147483822 @default.
• W2142598127 hasConcept C154317977 @default.
• W2142598127 hasConcept C170627219 @default.
• W2142598127 hasConcept C185592680 @default.
• W2142598127 hasConcept C197695756 @default.
• W2142598127 hasConcept C202751555 @default.
• W2142598127 hasConcept C203014093 @default.
• W2142598127 hasConcept C207936829 @default.
• W2142598127 hasConcept C2776090121 @default.
• W2142598127 hasConcept C2778814158 @default.
• W2142598127 hasConcept C39347974 @default.
• W2142598127 hasConcept C55493867 @default.
• W2142598127 hasConcept C59822182 @default.
• W2142598127 hasConcept C67662055 @default.
• W2142598127 hasConcept C81444415 @default.
• W2142598127 hasConcept C83464605 @default.
• W2142598127 hasConcept C86803240 @default.
• W2142598127 hasConcept C8891405 @default.
• W2142598127 hasConcept C95444343 @default.
• W2142598127 hasConceptScore W2142598127C100701293 @default.
• W2142598127 hasConceptScore W2142598127C147483822 @default.
• W2142598127 hasConceptScore W2142598127C154317977 @default.
• W2142598127 hasConceptScore W2142598127C170627219 @default.
• W2142598127 hasConceptScore W2142598127C185592680 @default.
• W2142598127 hasConceptScore W2142598127C197695756 @default.
• W2142598127 hasConceptScore W2142598127C202751555 @default.
• W2142598127 hasConceptScore W2142598127C203014093 @default.
• W2142598127 hasConceptScore W2142598127C207936829 @default.
• W2142598127 hasConceptScore W2142598127C2776090121 @default.
• W2142598127 hasConceptScore W2142598127C2778814158 @default.
• W2142598127 hasConceptScore W2142598127C39347974 @default.
• W2142598127 hasConceptScore W2142598127C55493867 @default.
• W2142598127 hasConceptScore W2142598127C59822182 @default.
• W2142598127 hasConceptScore W2142598127C67662055 @default.
• W2142598127 hasConceptScore W2142598127C81444415 @default.
• W2142598127 hasConceptScore W2142598127C83464605 @default.
• W2142598127 hasConceptScore W2142598127C86803240 @default.
• W2142598127 hasConceptScore W2142598127C8891405 @default.

• next