FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142622012> ?p ?o ?g. }

• W2142622012 endingPage "96" @default.
• W2142622012 startingPage "87" @default.
• W2142622012 abstract "Distal expression quantitative trait loci (distal eQTLs) are genetic mutations that affect the expression of genes genomically far away. However, the mechanisms that cause a distal eQTL to modulate gene expression are not yet clear. Recent high-resolution chromosome conformation capture experiments along with a growing database of eQTLs provide an opportunity to understand the spatial mechanisms influencing distal eQTL associations on a genome-wide scale. We test the hypothesis that spatial proximity contributes to eQTL-gene regulation in the context of the higher-order domain structure of chromatin as determined from recent Hi-C chromosome conformation experiments. This analysis suggests that the large-scale topology of chromatin is coupled with eQTL associations by providing evidence that eQTLs are in general spatially close to their target genes, occur often around topological domain boundaries and preferentially associate with genes across domains. We also find that within-domain eQTLs that overlap with regulatory elements such as promoters and enhancers are spatially more close than the overall set of within-domain eQTLs, suggesting that spatial proximity derived from the domain structure in chromatin plays an important role in the regulation of gene expression." @default.
• W2142622012 created "2016-06-24" @default.
• W2142622012 creator A5034451361 @default.
• W2142622012 creator A5058132020 @default.
• W2142622012 creator A5074759984 @default.
• W2142622012 date "2013-10-01" @default.
• W2142622012 modified "2023-10-16" @default.
• W2142622012 title "Higher-order chromatin domains link eQTLs with the expression of far-away genes" @default.
• W2142622012 cites W128439093 @default.
• W2142622012 cites W1558882143 @default.
• W2142622012 cites W1945579058 @default.
• W2142622012 cites W1964184081 @default.
• W2142622012 cites W1973064777 @default.
• W2142622012 cites W1984939442 @default.
• W2142622012 cites W1992088789 @default.
• W2142622012 cites W2001320379 @default.
• W2142622012 cites W2001576815 @default.
• W2142622012 cites W2002404684 @default.
• W2142622012 cites W2027455260 @default.
• W2142622012 cites W2030948026 @default.
• W2142622012 cites W2033202128 @default.
• W2142622012 cites W2043842514 @default.
• W2142622012 cites W2054936253 @default.
• W2142622012 cites W2059742736 @default.
• W2142622012 cites W2067673709 @default.
• W2142622012 cites W2069298307 @default.
• W2142622012 cites W2070021921 @default.
• W2142622012 cites W2070568765 @default.
• W2142622012 cites W2090037139 @default.
• W2142622012 cites W2097128336 @default.
• W2142622012 cites W2099591793 @default.
• W2142622012 cites W2108615748 @default.
• W2142622012 cites W2110614590 @default.
• W2142622012 cites W2112087830 @default.
• W2142622012 cites W2136091734 @default.
• W2142622012 cites W2140951889 @default.
• W2142622012 cites W2142260323 @default.
• W2142622012 cites W2148407411 @default.
• W2142622012 cites W2148589630 @default.
• W2142622012 cites W2170696599 @default.
• W2142622012 cites W2172042768 @default.
• W2142622012 cites W4210347168 @default.
• W2142622012 doi "https://doi.org/10.1093/nar/gkt857" @default.
• W2142622012 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3874174" @default.
• W2142622012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24089144" @default.
• W2142622012 hasPublicationYear "2013" @default.
• W2142622012 type Work @default.
• W2142622012 sameAs 2142622012 @default.
• W2142622012 citedByCount "47" @default.
• W2142622012 countsByYear W21426220122014 @default.
• W2142622012 countsByYear W21426220122015 @default.
• W2142622012 countsByYear W21426220122016 @default.
• W2142622012 countsByYear W21426220122017 @default.
• W2142622012 countsByYear W21426220122018 @default.
• W2142622012 countsByYear W21426220122019 @default.
• W2142622012 countsByYear W21426220122020 @default.
• W2142622012 countsByYear W21426220122021 @default.
• W2142622012 countsByYear W21426220122022 @default.
• W2142622012 countsByYear W21426220122023 @default.
• W2142622012 crossrefType "journal-article" @default.
• W2142622012 hasAuthorship W2142622012A5034451361 @default.
• W2142622012 hasAuthorship W2142622012A5058132020 @default.
• W2142622012 hasAuthorship W2142622012A5074759984 @default.
• W2142622012 hasBestOaLocation W21426220122 @default.
• W2142622012 hasConcept C104317684 @default.
• W2142622012 hasConcept C111936080 @default.
• W2142622012 hasConcept C135763542 @default.
• W2142622012 hasConcept C150194340 @default.
• W2142622012 hasConcept C151730666 @default.
• W2142622012 hasConcept C153209595 @default.
• W2142622012 hasConcept C165864922 @default.
• W2142622012 hasConcept C167227067 @default.
• W2142622012 hasConcept C168393362 @default.
• W2142622012 hasConcept C2779343474 @default.
• W2142622012 hasConcept C54355233 @default.
• W2142622012 hasConcept C67258246 @default.
• W2142622012 hasConcept C70721500 @default.
• W2142622012 hasConcept C81941488 @default.
• W2142622012 hasConcept C83640560 @default.
• W2142622012 hasConcept C86803240 @default.
• W2142622012 hasConcept C93946551 @default.
• W2142622012 hasConceptScore W2142622012C104317684 @default.
• W2142622012 hasConceptScore W2142622012C111936080 @default.
• W2142622012 hasConceptScore W2142622012C135763542 @default.
• W2142622012 hasConceptScore W2142622012C150194340 @default.
• W2142622012 hasConceptScore W2142622012C151730666 @default.
• W2142622012 hasConceptScore W2142622012C153209595 @default.
• W2142622012 hasConceptScore W2142622012C165864922 @default.
• W2142622012 hasConceptScore W2142622012C167227067 @default.
• W2142622012 hasConceptScore W2142622012C168393362 @default.
• W2142622012 hasConceptScore W2142622012C2779343474 @default.
• W2142622012 hasConceptScore W2142622012C54355233 @default.
• W2142622012 hasConceptScore W2142622012C67258246 @default.
• W2142622012 hasConceptScore W2142622012C70721500 @default.
• W2142622012 hasConceptScore W2142622012C81941488 @default.
• W2142622012 hasConceptScore W2142622012C83640560 @default.
• W2142622012 hasConceptScore W2142622012C86803240 @default.
• W2142622012 hasConceptScore W2142622012C93946551 @default.

• next