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- W2142624712 abstract "An unbiased phosphoproteomic method was used to identify biomaterial-associated changes in the phosphorylation patterns of macrophage-like cells. The phosphorylation differences between differentiated THP1 (dTHP1) cells treated for 10, 20, or 30 min with a vascular regenerative methacrylic acid (MAA) copolymer or a control methyl methacrylate (MM) copolymer were determined by MS. There were 1,470 peptides (corresponding to 729 proteins) that were differentially phosphorylated in dTHP1 cells treated with the two materials with a greater cellular response to MAA treatment. In addition to identifying pathways (such as integrin signaling and cytoskeletal arrangement) that are well known to change with cell-material interaction, previously unidentified pathways, such as apoptosis and mRNA splicing, were also discovered." @default.
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- W2142624712 date "2015-08-10" @default.
- W2142624712 modified "2023-10-13" @default.
- W2142624712 title "Unbiased phosphoproteomic method identifies the initial effects of a methacrylic acid copolymer on macrophages" @default.
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- W2142624712 doi "https://doi.org/10.1073/pnas.1508826112" @default.
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