FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142628303> ?p ?o ?g. }

• W2142628303 endingPage "625" @default.
• W2142628303 startingPage "619" @default.
• W2142628303 abstract "Objective The p.V600E BRAF and RAS mutations are found in 30–80% of differentiated thyroid carcinoma (DTC). BRAF mutation has been associated with poor prognosis. This study investigated the role of molecular studies in preoperative diagnosis of DTC and the association of p.V600E mutation with prognostic factors. Design Prospective study. Methods A total of 202 patients with cytological diagnosis of Bethesda III–VI underwent preoperative molecular studies and subsequent thyroidectomy. p.V600E and RAS mutations were studied in the cytology smears, using real-time PCR genotyping technique. The BRAF mutation (BRAF + or BRAF − ) was correlated with histological and clinical findings. Results Molecular study of 172 nodules with Bethesda III–V cytology improved negative predictive value and accuracy of Bethesda III and IV diagnosis. BRAF mutation was present in 65% of 94 DTC and p.Q61R NRAS in one. Except for age, BRAF + and BRAF − did not differ in sex, tumor size, histological subtype, multifocality, vascular invasion, extrathyroidal extension, or prognostic staging. Among papillary carcinomas, lymph node (LN) metastasis was diagnosed in 23% BRAF + and 37% BRAF − . Distant metastasis occurred in four BRAF − . Recurrent or persistent disease was more frequent in BRAF − (26.7 vs 3.3% BRAF + , P =0.002) along follow-up of 29.8±10 months. BRAF + patients without LN metastasis by pre-operative evaluation submitted to thyroidectomy with central neck dissection (CND) had more frequent LN metastasis (45 vs 5% no CND, P =0.002), but no difference in clinical outcome was observed. Conclusions Pre-operative identification of BRAF mutation improved cytological diagnosis of DTC, but it was not associated with poor prognostic factors. Prophylactic CND did not guarantee better outcome in BRAF + patients." @default.
• W2142628303 created "2016-06-24" @default.
• W2142628303 creator A5001083050 @default.
• W2142628303 creator A5006947072 @default.
• W2142628303 creator A5056081475 @default.
• W2142628303 creator A5073305828 @default.
• W2142628303 creator A5076715608 @default.
• W2142628303 creator A5091747699 @default.
• W2142628303 date "2014-04-01" @default.
• W2142628303 modified "2023-10-08" @default.
• W2142628303 title "Pre-operative role of BRAF in the guidance of the surgical approach and prognosis of differentiated thyroid carcinoma" @default.
• W2142628303 cites W1525985826 @default.
• W2142628303 cites W1587471896 @default.
• W2142628303 cites W1965481481 @default.
• W2142628303 cites W1970723740 @default.
• W2142628303 cites W1971483095 @default.
• W2142628303 cites W1976052099 @default.
• W2142628303 cites W1976963260 @default.
• W2142628303 cites W1977602504 @default.
• W2142628303 cites W1981915061 @default.
• W2142628303 cites W1984135618 @default.
• W2142628303 cites W1984185945 @default.
• W2142628303 cites W2025370928 @default.
• W2142628303 cites W2030695368 @default.
• W2142628303 cites W2038680452 @default.
• W2142628303 cites W2055599569 @default.
• W2142628303 cites W2061877182 @default.
• W2142628303 cites W2069258306 @default.
• W2142628303 cites W2077811132 @default.
• W2142628303 cites W2077963729 @default.
• W2142628303 cites W2083963174 @default.
• W2142628303 cites W2100378386 @default.
• W2142628303 cites W2108643456 @default.
• W2142628303 cites W2114219024 @default.
• W2142628303 cites W2116542352 @default.
• W2142628303 cites W2133960355 @default.
• W2142628303 cites W2152446218 @default.
• W2142628303 cites W2156058243 @default.
• W2142628303 doi "https://doi.org/10.1530/eje-13-0944" @default.
• W2142628303 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24468978" @default.
• W2142628303 hasPublicationYear "2014" @default.
• W2142628303 type Work @default.
• W2142628303 sameAs 2142628303 @default.
• W2142628303 citedByCount "27" @default.
• W2142628303 countsByYear W21426283032014 @default.
• W2142628303 countsByYear W21426283032015 @default.
• W2142628303 countsByYear W21426283032016 @default.
• W2142628303 countsByYear W21426283032017 @default.
• W2142628303 countsByYear W21426283032018 @default.
• W2142628303 countsByYear W21426283032019 @default.
• W2142628303 countsByYear W21426283032020 @default.
• W2142628303 countsByYear W21426283032021 @default.
• W2142628303 countsByYear W21426283032023 @default.
• W2142628303 crossrefType "journal-article" @default.
• W2142628303 hasAuthorship W2142628303A5001083050 @default.
• W2142628303 hasAuthorship W2142628303A5006947072 @default.
• W2142628303 hasAuthorship W2142628303A5056081475 @default.
• W2142628303 hasAuthorship W2142628303A5073305828 @default.
• W2142628303 hasAuthorship W2142628303A5076715608 @default.
• W2142628303 hasAuthorship W2142628303A5091747699 @default.
• W2142628303 hasBestOaLocation W21426283031 @default.
• W2142628303 hasConcept C104317684 @default.
• W2142628303 hasConcept C121608353 @default.
• W2142628303 hasConcept C126322002 @default.
• W2142628303 hasConcept C142724271 @default.
• W2142628303 hasConcept C143998085 @default.
• W2142628303 hasConcept C21790070 @default.
• W2142628303 hasConcept C2776470698 @default.
• W2142628303 hasConcept C2777074255 @default.
• W2142628303 hasConcept C2777546739 @default.
• W2142628303 hasConcept C2778474501 @default.
• W2142628303 hasConcept C2779013556 @default.
• W2142628303 hasConcept C2779761222 @default.
• W2142628303 hasConcept C2781187634 @default.
• W2142628303 hasConcept C2993294228 @default.
• W2142628303 hasConcept C501734568 @default.
• W2142628303 hasConcept C526584372 @default.
• W2142628303 hasConcept C526805850 @default.
• W2142628303 hasConcept C55493867 @default.
• W2142628303 hasConcept C71924100 @default.
• W2142628303 hasConcept C86803240 @default.
• W2142628303 hasConcept C90924648 @default.
• W2142628303 hasConceptScore W2142628303C104317684 @default.
• W2142628303 hasConceptScore W2142628303C121608353 @default.
• W2142628303 hasConceptScore W2142628303C126322002 @default.
• W2142628303 hasConceptScore W2142628303C142724271 @default.
• W2142628303 hasConceptScore W2142628303C143998085 @default.
• W2142628303 hasConceptScore W2142628303C21790070 @default.
• W2142628303 hasConceptScore W2142628303C2776470698 @default.
• W2142628303 hasConceptScore W2142628303C2777074255 @default.
• W2142628303 hasConceptScore W2142628303C2777546739 @default.
• W2142628303 hasConceptScore W2142628303C2778474501 @default.
• W2142628303 hasConceptScore W2142628303C2779013556 @default.
• W2142628303 hasConceptScore W2142628303C2779761222 @default.
• W2142628303 hasConceptScore W2142628303C2781187634 @default.
• W2142628303 hasConceptScore W2142628303C2993294228 @default.
• W2142628303 hasConceptScore W2142628303C501734568 @default.
• W2142628303 hasConceptScore W2142628303C526584372 @default.

• next