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• W2142663838 abstract "At the immunological synapse, activated leukocyte cell adhesion molecules (ALCAM) on the dendritic cell (DC) and CD6 molecules on the T cell contribute to sustained DC-T cell contacts. However, little is known about how ALCAM-CD6 bonds resist and adapt to mechanical stress. Here, we combine single-cell force spectroscopy (SCFS) with total-internal fluorescence microscopy (TIRFM) to examine ALCAM-CD6-mediated cell adhesion. The combination of cells expressing ALCAM-constructs with specific cytoplasmic tail mutations and improved SCFS analysis routines reveal that the affinity of ALCAM-CD6 bonds is not influenced by linking of the intracellular domains of ALCAM to the actin cortex. In contrast, the recruitment of ALCAM to adhesion sites and the propensity of ALCAM to anchor plasma membrane tethers depend on actin cytoskeletal interactions. Furthermore, linking ALCAM to the actin cortex by adaptor proteins stiffens the cortex and strengthens cell adhesion. We propose a framework of how ALCAMs contribute to DC-T cell adhesion, stabilize DC-T cell contacts, and form a mechanical link between CD6 and the actin cortex to strengthen cell adhesion at the immunological synapse." @default.
• W2142663838 created "2016-06-24" @default.
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• W2142663838 date "2014-01-01" @default.
• W2142663838 modified "2023-10-12" @default.
• W2142663838 title "Dynamic coupling of ALCAM to the actin cortex strengthens cell adhesion to CD6" @default.
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• W2142663838 doi "https://doi.org/10.1242/jcs.141077" @default.
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