Matches in SemOpenAlex for { <https://semopenalex.org/work/W2142666676> ?p ?o ?g. }
- W2142666676 endingPage "703" @default.
- W2142666676 startingPage "697" @default.
- W2142666676 abstract "Modafinil, a wake-promoting drug used to treat narcolepsy, is a dopamine transporter inhibitor and is said to have very low abuse liability; this, however, is still up for debate. We conducted a dopamine transporter (DAT) occupancy study with modafinil (200 or 300 mg) in ten healthy volunteers using positron emission tomography (PET) with [¹⁸F]FE-PE2I, a new PET radioligand with high affinity and selectivity for the dopamine transporter, to characterize its relation to abuse liability. Mean striatal DAT occupancies were 51.4% at 200 mg and 56.9% at 300 mg. There was a significant correlation between occupancy and plasma concentration, indicating dose dependency of DAT inhibition by modafinil in the striatum, and especially in the nucleus accumbens. This study showed that DAT occupancy by modafinil was close to that of methylphenidate, indicating that modafinil may be near the same level as methylphenidate in relation to abuse liability in terms of dopaminergic transmission." @default.
- W2142666676 created "2016-06-24" @default.
- W2142666676 creator A5007404554 @default.
- W2142666676 creator A5012715569 @default.
- W2142666676 creator A5026948578 @default.
- W2142666676 creator A5030236221 @default.
- W2142666676 creator A5031416330 @default.
- W2142666676 creator A5086525882 @default.
- W2142666676 creator A5089350264 @default.
- W2142666676 date "2014-01-22" @default.
- W2142666676 modified "2023-10-13" @default.
- W2142666676 title "In vivo activity of modafinil on dopamine transporter measured with positron emission tomography and [18F]FE-PE2I" @default.
- W2142666676 cites W1863468761 @default.
- W2142666676 cites W1967074507 @default.
- W2142666676 cites W1977634040 @default.
- W2142666676 cites W1981679498 @default.
- W2142666676 cites W1984766715 @default.
- W2142666676 cites W1986105672 @default.
- W2142666676 cites W1988296887 @default.
- W2142666676 cites W1990834867 @default.
- W2142666676 cites W1992741100 @default.
- W2142666676 cites W1994248961 @default.
- W2142666676 cites W2005224895 @default.
- W2142666676 cites W2018944162 @default.
- W2142666676 cites W2027968086 @default.
- W2142666676 cites W2032654155 @default.
- W2142666676 cites W2033200028 @default.
- W2142666676 cites W2033372335 @default.
- W2142666676 cites W2033756513 @default.
- W2142666676 cites W2034828200 @default.
- W2142666676 cites W2035227577 @default.
- W2142666676 cites W2040480454 @default.
- W2142666676 cites W2041956134 @default.
- W2142666676 cites W2048727294 @default.
- W2142666676 cites W2055500305 @default.
- W2142666676 cites W2062608310 @default.
- W2142666676 cites W2070780907 @default.
- W2142666676 cites W2071156130 @default.
- W2142666676 cites W2083946354 @default.
- W2142666676 cites W2095217951 @default.
- W2142666676 cites W2105153214 @default.
- W2142666676 cites W2112278807 @default.
- W2142666676 cites W2114177397 @default.
- W2142666676 cites W2117671988 @default.
- W2142666676 cites W2121878832 @default.
- W2142666676 cites W2122011624 @default.
- W2142666676 cites W2124767905 @default.
- W2142666676 cites W2126292584 @default.
- W2142666676 cites W2130668599 @default.
- W2142666676 cites W2135588856 @default.
- W2142666676 cites W2137819234 @default.
- W2142666676 cites W2157181473 @default.
- W2142666676 cites W2157957979 @default.
- W2142666676 cites W2952462837 @default.
- W2142666676 cites W4234193446 @default.
- W2142666676 cites W4238322642 @default.
- W2142666676 doi "https://doi.org/10.1017/s1461145713001612" @default.
- W2142666676 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24451483" @default.
- W2142666676 hasPublicationYear "2014" @default.
- W2142666676 type Work @default.
- W2142666676 sameAs 2142666676 @default.
- W2142666676 citedByCount "33" @default.
- W2142666676 countsByYear W21426666762014 @default.
- W2142666676 countsByYear W21426666762015 @default.
- W2142666676 countsByYear W21426666762016 @default.
- W2142666676 countsByYear W21426666762017 @default.
- W2142666676 countsByYear W21426666762018 @default.
- W2142666676 countsByYear W21426666762019 @default.
- W2142666676 countsByYear W21426666762020 @default.
- W2142666676 countsByYear W21426666762021 @default.
- W2142666676 countsByYear W21426666762022 @default.
- W2142666676 countsByYear W21426666762023 @default.
- W2142666676 crossrefType "journal-article" @default.
- W2142666676 hasAuthorship W2142666676A5007404554 @default.
- W2142666676 hasAuthorship W2142666676A5012715569 @default.
- W2142666676 hasAuthorship W2142666676A5026948578 @default.
- W2142666676 hasAuthorship W2142666676A5030236221 @default.
- W2142666676 hasAuthorship W2142666676A5031416330 @default.
- W2142666676 hasAuthorship W2142666676A5086525882 @default.
- W2142666676 hasAuthorship W2142666676A5089350264 @default.
- W2142666676 hasBestOaLocation W21426666761 @default.
- W2142666676 hasConcept C118552586 @default.
- W2142666676 hasConcept C126322002 @default.
- W2142666676 hasConcept C137183658 @default.
- W2142666676 hasConcept C15744967 @default.
- W2142666676 hasConcept C169760540 @default.
- W2142666676 hasConcept C185592680 @default.
- W2142666676 hasConcept C2775842073 @default.
- W2142666676 hasConcept C2776552330 @default.
- W2142666676 hasConcept C2776755682 @default.
- W2142666676 hasConcept C2777112843 @default.
- W2142666676 hasConcept C2780714222 @default.
- W2142666676 hasConcept C2780783007 @default.
- W2142666676 hasConcept C42219234 @default.
- W2142666676 hasConcept C513476851 @default.
- W2142666676 hasConcept C71924100 @default.
- W2142666676 hasConcept C98274493 @default.
- W2142666676 hasConceptScore W2142666676C118552586 @default.