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- W2142690129 abstract "Cyclooxygenase (Cox)-2 dependent PGs modulate several functions in many pathophysiological processes, including migration of immune cells. In this study, we addressed the role of Cox-2 in macrophage migration by using in vivo and in vitro models. Upon thioglycolate challenge, CD11b(+) F4/80(+) macrophages showed a diminished ability to migrate to the peritoneal cavity in cox-2(-/-) mice. In vivo migration of cox-2(-/-) macrophages from the peritoneal cavity to lymph nodes, as well as cell adhesion to the mesothelium, was reduced in response to LPS. In vitro migration of cox-2(-/-) macrophages toward MCP-1, RANTES, MIP-1α, or MIP-1β, as well as cell adhesion to ICAM-1 or fibronectin, was impaired. Defects in cell migration were not due to changes in chemokine receptor expression. Remarkably, cox-2(-/-) macrophages showed a deficiency in focal adhesion formation, with reduced phosphorylation of paxillin (Tyr(188)). Interestingly, expression of the p110γ catalytic subunit of PI3K was severely reduced in the absence of Cox-2, leading to defective Akt phosphorylation, as well as cdc42 and Rac-1 activation. Our results indicate that the paxillin/p110γ-PI3K/Cdc42/Rac1 axis is defective in cox-2(-/-) macrophages, which results in impaired cell adhesion and migration." @default.
- W2142690129 created "2016-06-24" @default.
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- W2142690129 creator A5063080095 @default.
- W2142690129 date "2013-07-01" @default.
- W2142690129 modified "2023-10-17" @default.
- W2142690129 title "Cyclooxygenase-2 Deficiency in Macrophages Leads to Defective p110γ PI3K Signaling and Impairs Cell Adhesion and Migration" @default.
- W2142690129 cites W1580246547 @default.
- W2142690129 cites W1865638244 @default.
- W2142690129 cites W1895115148 @default.
- W2142690129 cites W1960367851 @default.
- W2142690129 cites W1964064254 @default.
- W2142690129 cites W1968623565 @default.
- W2142690129 cites W1973996451 @default.
- W2142690129 cites W1975205173 @default.
- W2142690129 cites W1976620258 @default.
- W2142690129 cites W1981336118 @default.
- W2142690129 cites W1983177410 @default.
- W2142690129 cites W1983735472 @default.
- W2142690129 cites W1985844039 @default.
- W2142690129 cites W1987199189 @default.
- W2142690129 cites W2002148098 @default.
- W2142690129 cites W2002934448 @default.
- W2142690129 cites W2005631373 @default.
- W2142690129 cites W2006167391 @default.
- W2142690129 cites W2006221512 @default.
- W2142690129 cites W2006826186 @default.
- W2142690129 cites W2007087804 @default.
- W2142690129 cites W2013079253 @default.
- W2142690129 cites W2015141049 @default.
- W2142690129 cites W2017085163 @default.
- W2142690129 cites W2017929299 @default.
- W2142690129 cites W2024713922 @default.
- W2142690129 cites W2033172475 @default.
- W2142690129 cites W2035809865 @default.
- W2142690129 cites W2039026140 @default.
- W2142690129 cites W2039584708 @default.
- W2142690129 cites W2041065162 @default.
- W2142690129 cites W2044161694 @default.
- W2142690129 cites W2044296671 @default.
- W2142690129 cites W2048006877 @default.
- W2142690129 cites W2048674030 @default.
- W2142690129 cites W2048845468 @default.
- W2142690129 cites W2055744180 @default.
- W2142690129 cites W2059695583 @default.
- W2142690129 cites W2059839442 @default.
- W2142690129 cites W2061440101 @default.
- W2142690129 cites W2071117491 @default.
- W2142690129 cites W2072696221 @default.
- W2142690129 cites W2084093396 @default.
- W2142690129 cites W2087142375 @default.
- W2142690129 cites W2089767083 @default.
- W2142690129 cites W2090928408 @default.
- W2142690129 cites W2091119718 @default.
- W2142690129 cites W2093178516 @default.
- W2142690129 cites W2096542385 @default.
- W2142690129 cites W2101249156 @default.
- W2142690129 cites W2106024776 @default.
- W2142690129 cites W2107447190 @default.
- W2142690129 cites W2111334331 @default.
- W2142690129 cites W2123129088 @default.
- W2142690129 cites W2125064243 @default.
- W2142690129 cites W2127395361 @default.
- W2142690129 cites W2133317376 @default.
- W2142690129 cites W2133769266 @default.
- W2142690129 cites W2135925002 @default.
- W2142690129 cites W2137000898 @default.
- W2142690129 cites W2137475525 @default.
- W2142690129 cites W2140008727 @default.
- W2142690129 cites W2141320777 @default.
- W2142690129 cites W2143786800 @default.
- W2142690129 cites W2145740221 @default.
- W2142690129 cites W2146082012 @default.
- W2142690129 cites W2147330842 @default.
- W2142690129 cites W2151340873 @default.
- W2142690129 cites W2152571985 @default.
- W2142690129 cites W2156861923 @default.
- W2142690129 cites W2162378671 @default.
- W2142690129 cites W2166118660 @default.
- W2142690129 cites W2168948302 @default.
- W2142690129 cites W2169344740 @default.
- W2142690129 cites W2310034942 @default.
- W2142690129 cites W2491492261 @default.
- W2142690129 cites W4361865146 @default.
- W2142690129 doi "https://doi.org/10.4049/jimmunol.1202002" @default.
- W2142690129 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23733875" @default.
- W2142690129 hasPublicationYear "2013" @default.
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