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• W2142702057 endingPage "919" @default.
• W2142702057 startingPage "901" @default.
• W2142702057 abstract "Conjugates of bisphosphonates (potential bone resorption inhibitors) and prostaglandin E2 (a bone formation enhancer) were prepared and evaluated for their ability to bind to bone and to liberate, enzymatically, free PGE2. The conjugate 3, an amide at C-1 of PGE2 proved to be too stable in vivo while conjugate 6, a thioester, was too labile. Several PGE2, C-15 ester-linked conjugates (18, 23, 24 and 31) were prepared and conjugate 23 was found to bind effectively to bone in vitro and in vivo and to liberate PGE2 at an acceptable rate. A 4-week study in a rat model of osteoporosis showed that 23 was better tolerated and more effective as a bone growth stimulant than daily maximum tolerated doses of free PGE2." @default.
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• W2142702057 date "1999-05-01" @default.
• W2142702057 modified "2023-10-06" @default.
• W2142702057 title "Prostaglandin E2-bisphosphonate conjugates: potential agents for treatment of osteoporosis" @default.
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• W2142702057 doi "https://doi.org/10.1016/s0968-0896(99)00045-0" @default.
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• W2142702057 hasPublicationYear "1999" @default.
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